Brain

ANN ARBOR—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.

Leptin is a hormone secreted by fat tissue that has been of interest for researchers in obesity and Type 2 diabetes since it was discovered in 1995. Like insulin, leptin is part of a regulatory network that controls intake and expenditure of energy in the body, and a lack of leptin or resistance to it has been linked to obesity in people.

Babies born prematurely to low-income parents have a disproportionately high risk for developing dangerous brain bleeds that require multiple surgeries and extensive follow-up, according to a small Johns Hopkins Children's Center study.

The findings - published online Sept. 28 in the journal Pediatric Neurosurgery and based on an analysis of 38 patients referred to Johns Hopkins for treatment of brain hemorrhages related to premature birth - offer a sobering reminder of the role socio-economic factors can play in health outcomes, the researchers say.

Amsterdam, NL, 11 October, 2012 – Dopamine is a neurotransmitter that is associated with emotions, movement, and the brain's pleasure and reward system. In the current issue of Advances in Neuroimmune Biology, investigators provide a broad overview of the direct and indirect role of dopamine in modulating the immune system and discuss how recent research has opened up new possibilities for treating diseases such as Parkinson's and Alzheimer's disease, schizophrenia, multiple sclerosis or even the autoimmune disorders.

Philadelphia, PA, October 11, 2012 – A paper by Shizhong Han and colleagues in the current issue of Biological Psychiatry implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.

The researchers set out to investigate susceptibility genes for cannabis dependence, as research has already shown that it has a strong genetic component.

If a 7-year-old is breezing through the "Harry Potter" books, studies indicate that he or she will be a strong reader later in life. Conversely, if a 7-year-old is struggling with "The Cat in the Hat," that child will most likely struggle with reading going forward.

New research from Stanford shows that brain scans can identify the neural differences between these two children, and could one day lead to an early warning system for struggling students.

Women are twice as likely as men to use emoticons in text messages, according to a new study from Rice University.

Emoticons are graphic symbols that use punctuation marks and letters to represent facial expressions to convey a person's mood, help provide context to a person's textual communication and clarify a message that could otherwise possibly be misconstrued.

Food marketers are masters at getting people to crave and consume the foods that they promote. In this study authors Dr. Brian Wansink, co-director of the Cornell University Center for Behavioral Economics in Child Nutrition and Professor of Marketing and Dr. Pierre Chandon, professor of Marketing at the leading French graduate school of business, INSEAD challenge popular assumptions that link food marketing and obesity.

PULLMAN, Wash.—Washington State University researchers have developed a new drug candidate that dramatically improves the cognitive function of rats with Alzheimer's-like mental impairment.

Scientists have found the first evidence that the ability to learn vocalizations, a capacity so far believed to be restricted to a handful of bird and mammal species like humans and dolphins, is shared by another species: mice. The new research, published Oct. 10 in the open access journal PLOS ONE by Erich Jarvis and Gustavo Arriaga at Duke University and colleagues, shows for the first time that mice share certain behavioral and brain mechanisms involved in vocal learning with songbirds and humans and can learn new vocal patterns.

DURHAM, N.C. -- Guys who imitate Luciano Pavarotti or Justin Bieber to get the girls aren't alone. Male mice may do a similar trick, matching the pitch of other males' ultrasonic serenades. The mice also have certain brain features, somewhat similar to humans and song-learning birds, which they may use to change their sounds, according to a new study.

JUPITER, FL, October 10, 2012 – Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified small variations in a number of genes that are closely linked to an increased risk of bipolar disorder, a mental illness that affects nearly six million Americans, according to the National Institute of Mental Health.

PORTLAND, Ore. – Physician-scientists at Oregon Health & Science University Doernbecher Children's Hospital have demonstrated for the first time that banked human neural stem cells — HuCNS-SCs, a proprietary product of StemCells Inc. — can survive and make functional myelin in mice with severe symptoms of myelin loss. Myelin is the critical fatty insulation, or sheath, surrounding new nerve fibers and is essential for normal brain function.

A Phase I clinical trial led by investigators from the University of California, San Francisco and sponsored by Stem Cells Inc., showed that neural stem cells successfully engrafted into the brains of patients and appear to have produced myelin.

The study, published in the Oct. 10, 2012 issue of Science Translational Medicine, also demonstrated that the neural stem cells were safe in the patients' brains one year post transplant.

The remarkably well-preserved fossil of an extinct arthropod shows that anatomically complex brains evolved earlier than previously thought and have changed little over the course of evolution. According to University of Arizona neurobiologist Nicholas Strausfeld, who co-authored the study describing the specimen, the fossil is the earliest known to show a brain.

The discovery will be published in the Oct. 11 issue of the journal Nature.