Brain

INDIANAPOLIS -- A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer's disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer's -- but has uncovered an association with a second gene, called BCHE.

A team of researchers at UC San Francisco has uncovered the neurological basis of speech motor control, the complex coordinated activity of tiny brain regions that controls our lips, jaw, tongue and larynx as we speak.

Described this week in the journal Nature, the work has potential implications for developing computer-brain interfaces for artificial speech communication and for the treatment of speech disorders. It also sheds light on an ability that is unique to humans among living creatures but poorly understood.

Good mental health and clear thinking depend upon our ability to store and manipulate thoughts on a sort of "mental sketch pad." In a new study, Yale School of Medicine researchers describe the molecular basis of this ability — the hallmark of human cognition — and describe how a breakdown of the system contributes to diseases such as schizophrenia and Alzheimer's disease.

The most common inherited form of mental retardation and autism, fragile X syndrome, turns some brain cells into chatterboxes, scientists at Washington University School of Medicine in St. Louis report.

The extra talk may make it harder for brain cells to identify and attend to important signals, potentially establishing an intriguing parallel at the cellular level to the attention problems seen in autism.

According to the researchers, understanding the effects of this altered signaling will be important to developing successful treatments for fragile X and autism.

ATLANTA – Children with brain lesions suffered before or around the time of birth are able to use gestures – an important aspect of the language learning process– to convey simple sentences, a Georgia State University researcher has found.

A study conducted at the University of Granada and the University of York in Toronto, Canada, has revealed that bilingual children develop a better working memory –which holds, processes and updates information over short periods of time– than monolingual children. The working memory plays a major role in the execution of a wide range of activities, such as mental calculation (since we have to remember numbers and operate with them) or reading comprehension (given that it requires associating the successive concepts in a text).

New research shows that people can recover from poor performance when rivals comment on their failures. The research, to be published in the Journal of Experimental Social Psychology, shows that while criticism from team members sends individuals into downward performance spirals, external criticism can be a trigger that boosts performance as people try to prove the outsiders wrong.

Electrodes operated into the brain are today used in research and to treat diseases such as Parkinson's. However, their use has been limited by their size. At Lund University in Sweden, researchers have, for the first time, succeeded in implanting an ultrathin nanowire-based electrode and capturing signals from the nerve cells in the brain of a laboratory animal.

Adding movement to mental rehearsal can improve performance finds a study in BioMed Central's open access journal Behavioral and Brain Functions. For high jumpers the study shows that dynamic imagery improves the number of successful attempts and the technical performance of jumps.

Washington, DC — Male rat pups have more of a specific brain protein associated with language development than females, according to a study published February 20 in The Journal of Neuroscience. The study also found sex differences in the brain protein in a small group of children. The findings may shed light on sex differences in communication in animals and language acquisition in people.

EVANSTON, Ill. --- Though learning to read proceeds smoothly for most children, as many as one in 10 is estimated to suffer from dyslexia, a constellation of impairments unrelated to intelligence, hearing or vision that make learning to read a struggle. Now, Northwestern University researchers report they have found a biological mechanism that appears to play an important role in the reading process.

Despite current beliefs, the degenerative eye condition age-related macular degeneration is a common cause of vision impairment and blindness in sub-Saharan Africa, requiring an urgent review of vision services, according to a study by international researchers published in this week's PLOS Medicine.

New research out of the University of Cincinnati reveals a relatively rare look into the success of substance abuse treatment programs for African-Americans. Researchers report that self-motivation could be an important consideration into deciding on the most effective treatment strategy. The study led by Ann Kathleen Burlew, a UC professor of psychology, and LaTrice Montgomery, a UC assistant professor of human services, is published online this week in Psychology of Addictive Behaviors.

New York, NY (February 19, 2013) — New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer's disease.

BOSTON -- Models of the human brain, patterned on engineering control theory, may some day help researchers control such neurological diseases as epilepsy, Parkinson's and migraines, according to a Penn State researcher who is using mathematical models of neuron networks from which more complex brain models emerge.