Brain

SAN FRANCISCO, CA—September 28, 2014—Researchers at the Gladstone Institutes have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer's disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, scientists were able to prevent these abnormalities and block cell death in this model.

How the brain ages is still largely an open question – in part because this organ is mostly insulated from direct contact with other systems in the body, including the blood and immune systems. In research that was recently published in Science, Weizmann Institute researchers Prof. Michal Schwartz of the Neurobiology Department and Dr. Ido Amit of Immunology Department found evidence of a unique "signature" that may be the "missing link" between cognitive decline and aging.

Patients with Multiple Sclerosis (MS) were able to safely tolerate treatment with cells cultured from human placental tissue, according to a study published today in the journal Multiple Sclerosis and Related Disorders. The study, which is the first of its kind, was conducted by researchers at Mount Sinai, Celgene Cellular Therapeutics subsidiary of Celgene Corporation and collaborators at several other institutions.

CHAMPAIGN, Ill. — A nine-month-long, randomized controlled trial involving 221 prepubescent children found that those who engaged in moderate-to-vigorous physical activity for at least 60 minutes a day after school saw substantial improvements in their ability to pay attention, avoid distraction and switch between cognitive tasks, researchers report in the journal Pediatrics.

Each year 2.5 million children die worldwide because they do not receive life-saving vaccinations at the appropriate time.

Anil Jain, Michigan State University professor, is developing a fingerprint-based recognition method to track vaccination schedules for infants and toddlers, which will increase immunization coverage and save lives.

An international team of scientists, involving Professor Rodrigo Quian Quiroga, director of the Centre for Systems Neuroscience and Head of Bioengineering at the University of Leicester, has shown how individual neurons in the human brain react to ambiguous morphed faces.

For this, the researchers used images of celebrities, such as Angelina Jolie and Halle Berry, morphed together to create an ambiguous face which test subjects were asked to identify.

CINCINNATI – New research shows that disrupting the molecular function of a tumor suppressor causes improper formation of a protective insulating sheath on peripheral nerves – leading to neuropathy and muscle wasting in mice similar to that in human diabetes and neurodegeneration.

A hormone that governs sleep and jet lag in humans may also drive the mass migration of plankton in the ocean, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. The molecule in question, melatonin, is essential to maintain our daily rhythm, and the European scientists have now discovered that it governs the nightly migration of a plankton species from the surface to deeper waters.

Neurons programmed to fire at specific faces—such as the famously reported "Jennifer Aniston neuron"—may be more in line with the conscious recognition of faces than the actual images seen. Subjects presented with a blended face, such as an amalgamation of Bill Clinton and George W. Bush, had significantly more firing of such face-specific neurons when they recognized the blended or morphed face as one person or the other.

Empathy is typically seen as eliciting warmth and compassion—a generally positive state that makes people do good things to others. However, empathy may also motivate aggression on behalf of the vulnerable other. Researchers at the State University of New York at Buffalo, examined whether assessed or elicited empathy would lead to situation-specific aggression on behalf of another person, and to explore the potential role of two neurohormones in explaining a connection between empathy and aggression. The study is published in Personality and Social Psychology Bulletin.

A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research published today in the open access journal Stem Cell Research & Therapy. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer's disease.

While antidepressants are the most commonly used treatment for social anxiety disorder, new research suggests that cognitive behavioral therapy (CBT) is more effective and, unlike medication, can have lasting effects long after treatment has stopped.

Past experience is usually a reliable guide for making decisions, but in unpredictable and challenging situations, it might make more sense to take risks. A study published by Cell Press September 25th in the journal Cell shows that, in competitive situations, rats abandon their normal tactic of using past experience to make decisions and instead make random choices when their competitor is hard to defeat.

Tourette syndrome is a developmental disorder characterized by involuntary, repetitive, and stereotyped movements or utterances. Now researchers reporting in the Cell Press journal Current Biology on September 25 have new evidence to explain how those with Tourette syndrome in childhood often manage to gain control over those tics. In individuals with the condition, a portion of the brain involved in planning and executing movements shows an unusual increase compared to the average brain in the production of a primary inhibitory neurotransmitter known as GABA.

Physical exercise has many beneficial effects on human health, including the protection from stress-induced depression. However, until now the mechanisms that mediate this protective effect have been unknown. In a new study in mice, researchers at Karolinska Institutet in Sweden show that exercise training induces changes in skeletal muscle that can purge the blood of a substance that accumulates during stress, and is harmful to the brain. The study is being published in the prestigious journal Cell.