LA JOLLA, CA -February 11, 2016 - A new study in animal models, led by scientists at The Scripps Research Institute (TSRI), is the first to show that oxygen sensing in the brain has a role in metabolism and sensing an organism's internal state.
In a roundworm called C. elegans, cues picked up from the environment--specifically, the sensing of oxygen by the brain--determined how quickly the intestine burns fat. Surprisingly, this communication worked both ways, and fat reserves in the intestine could also influence the strength of the fat-burning signal from the nervous system.