Brain

Researchers from Mount Sinai School of Medicine have found that when one copy of the SHANK3 gene in mice is missing, nerve cells do not effectively communicate and do not show cellular properties associated with normal learning. This discovery may explain how mutations affecting SHANK3 may lead to autism spectrum disorders (ASDs). The research is currently published in Molecular Autism.

(Boston) - Current diagnostic procedures for posttraumatic stress disorder (PTSD) fail to adequately reflect research into the broad nature of a traumatic event, according to a study that will appear in the January print issue of Psychological Bulletin.

CAMBRIDGE, Mass. -- Researchers have created a powerful new approach to scholarship, using approximately 4 percent of all books ever published as a digital "fossil record" of human culture. By tracking the frequency with which words appear in books over time, scholars can now precisely quantify a wide variety of cultural and historical trends.

The four-year effort, led by Harvard University's Jean-Baptiste Michel and Erez Lieberman Aiden, is described this week in the journal Science.

Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children. The large multicenter study defines the genetic landscape of this cancer, and holds intriguing clues to gene changes on signaling pathways that may become fruitful targets for future therapies.

Older people have a hard time keeping a lid on their feelings, especially when viewing heartbreaking or disgusting scenes in movies and reality shows, psychologists have found. But they're better than their younger counterparts at seeing the positive side of a stressful situation and empathizing with the less fortunate, according to research from the University of California, Berkeley.

Researchers at the University of Iowa have pinpointed the part of the brain that causes people to experience fear – a discovery that could improve treatment of post-traumatic stress disorder (PTSD) and other anxiety conditions.

A new study, published online on December 16 in Current Biology, a CellPress publication, offers new insight into the emotional life of aunique individual who completely lacks the function of an almond-shapedstructure in the brain known as the amygdala. Studies over the last 50years have shown that the amygdala plays a central role in generatingfear reactions in animals from rats to monkeys. Based on the detailedcase study of the woman identified only as SM, it now appears that thesame is true of humans.

Montreal, December 16, 2010 – Friendless kids can become social outcasts who risk spiraling into depression by adolescence, according to new research from Concordia University, Florida Atlantic University and the University of Vermont. Yet for most shy and withdrawn children, the study reports in the journal Development and Psychopathology, friends can be a form of protection against sadness.

A Japanese research group led by Prof. Ryusuke Kakigi and Dr. Emi Nakato (National Institute for Physiological Sciences: NIPS) and Prof. Masami K Yamaguchi (Chuo University) found that there was the different hemodynamic response in the temporal cortex between infants' perceptions of their own mother and of female strangers. The presentation of mother's face elicited increased hemodynamic responses in the bilateral temporal cortex. This finding was reported in Early Human Development.

ST. PAUL, Minn. – Requiring a second exam on a person who is considered brain dead may be unnecessary, according to a study on the impact of a second brain death exam on organ donation rates. The research is published in the December 15, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.

For the study, scientists reviewed the cases of 1,229 adults and 82 children ages one and older pronounced brain dead. The information was taken from the New York Organ Donor Network database during a 19-month period.

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers.

A small area deep in the brain called the perirhinal cortex is critical for forming unconscious conceptual memories, researchers at the UC Davis Center for Mind and Brain have found.

The perirhinal cortex was thought to be involved, like the neighboring hippocampus, in "declarative" or conscious memories, but the new results show that the picture is more complex, said lead author Wei-chun Wang, a graduate student at UC Davis.

The results were published Dec. 9 in the journal Neuron.

Montreal, December 15, 2010 – Conduct disorders in preteens are predictive of eventual teenage serious violent and delinquent behavior, according to a new study from the Université de Montréal. The findings, published in this month's issue of Journal of Child Psychology and Psychiatry, have implications for concerned parents.