Accumulation of the synaptic protein alpha-synuclein, resulting in the formation of masses called Lewy bodies in the brain, is a hallmark of Parkinson's and other related neurodegenerative diseases, that then spread throughout the brain. Now, researchers at the University of California, San Diego School of Medicine and Konkuk University in Seoul, South Korea, have described how this mechanism works. Their findings, which show neuron-to-neuron transmission of alpha-synuclein, will appear in the Proceedings of the National Academy of Sciences (PNAS).