The first genetic link in the evolution of the heart from three-chambered to four-chambered has been found, illuminating part of the puzzle of how birds and mammals became warm-blooded.
Frogs have a three-chambered heart. It consists of two atria and one ventricle. As the right side of a frog's heart receives deoxygenated blood from the body, and the left side receives freshly oxygenated blood from the lungs, the two streams of blood mix together in the ventricle, sending out a concoction that is not fully oxygenated to the rest of the frog's body.