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A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders.

HOUSTON – (Nov. 11, 2009) - Texas Children's Hospital is the nation's first pediatric hospital to discharge a child while on an intracorporeal ventricular assist device (VAD), a feat previously accomplished only at adult institutions. The patient, 16-year-old Francisco "Frank" De Santiago, who was implanted with a mechanical heart pump called the HeartMate II on May 19, 2009, was discharged on Oct. 29, 2009.

A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD). The research, published by Cell Press in the November 12 issue of the journal Neuron, finds that the novel gene interacts with a key cellular enzyme previously linked with AD pathology, thereby uncovering a new strategy for treating this devastating disorder.

Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed. Their discovery, published in the November 12 issue of Nature, lays the foundation for a new kind of therapy aimed directly at a critical human protein — one of a few thousand so-called transcription factors — that could someday be used to treat a variety of diseases, especially multiple types of cancer.

But isotope ratios recorded in rocks on the ocean floor are also dependent on the chemical composition of the seawater in which those rocks formed, and the past studies assumed the composition of the ancient ocean was essentially what it is today, which the Stanford study did not.

A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD). The research, published by Cell Press in the November 12 issue of the journal Neuron, finds that the novel gene interacts with a key cellular enzyme previously linked with AD pathology, thereby uncovering a new strategy for treating this devastating disorder.

Durham, NC – The most extensive DNA study to-date of Africa's rarest monkey reveals that the species had an intriguing sexual past. Of the last two remaining populations of the recently discovered kipunji, one population shows evidence of past mating with baboons while the other does not, says a new study in Biology Letters. The results may help to set conservation priorities for this critically endangered species, researchers say.

BUFFALO, N.Y. -- Supermarkets could increase their sales of related items, such as chips and soft drinks, by moving the items closer to each other in their stores, according to research by Ram Bezawada, assistant professor of marketing in the University at Buffalo School of Management.

"Retailers can benefit substantially by having better placement of items in their aisles," Bezawada says. His research shows that aisle placements can influence sales across product categories as much as other marketing variables, such as price or how an item is displayed.

Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ. Their focus was the liver, and their massive database in both protein and transcript levels could become a roadmap for finding possible new biomarkers and treatments for liver disease. Those include hepatitis and liver cancer, which is at epidemic levels in China and affects millions of people worldwide.

College athletes who use performance-enhancing substances may be at heightened risk of misusing alcohol and using recreational drugs as well, according to new research in the Journal of Studies on Alcohol and Drugs.

The study, of 234 male athletes at one university, found that those who used performance enhancers -- ranging from steroids to stimulants to weight-loss supplements -- were more likely to admit to heavy drinking and using drugs like marijuana and cocaine.

Scientists in Washington, DC, are reporting development and successful tests of a new way for exploring the insides of living cells, the microscopic building blocks of all known plants and animals. They explode the cell while it is still living inside a plant or animal, vaporize its contents, and sniff. The study appears in online in ACS' journal Analytical Chemistry.

Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. Those hard-to-treat diseases include malaria, tuberculosis, dengue fever, and other conditions. That's the topic of the cover story scheduled for the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.

The "chocolate cure" for emotional stress is getting new support from a clinical trial published online in ACS' Journal of Proteome Research. It found that eating about an ounce and a half of dark chocolate a day for two weeks reduced levels of stress hormones in the bodies of people feeling highly stressed. Everyone's favorite treat also partially corrected other stress-related biochemical imbalances.

FAIRFAX, Va.—Catheter-directed therapy or catheter-directed thrombolysis—an interventional radiology treatment that uses targeted image-guided drug delivery with specially designed catheters to dissolve dangerous blood clots in the lungs—saves lives and should be considered a first-line treatment option for massive pulmonary embolism, note researchers in the November Journal of Vascular and Interventional Radiology.

A team of mathematicians from the Engineering and Architecture Schools of the University of Seville has created a method to design underground lines whereby a city's historical buildings are unaffected. The results of the study, which has just been published in the Journal of the Operational Research Society, offer possible solutions for the future underground line 2 in Seville.