Body

PHILADELPHIA — Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells. In a study to be published May 7 in mBio®, the online open-access journal of the American Society for Microbiology, scientists at Emory University School of Medicine, the University of Virginia, and Universidad de las Islas Baleares in Mallorca, Spain, uncover this previously unknown virulence factor in P.

Having a neighborly chat improves seed germination, finds research in BioMed Central's open access journal BMC Ecology. Even when other known means of communication, such as contact, chemical and light-mediated signals, are blocked chilli seeds grow better when grown with basil plants. This suggests that plants are talking via nanomechanical vibrations.

Around 150 million people globally are chronically infected with the hepatitis C virus (HCV) – a major cause of liver disease and the fastest growing cause of liver transplantation and liver cancer. 1 New prevention strategies are urgently required as people are continuing to be infected with HCV. Findings, published in Hepatology, reveal the impact of a new antiviral treatment that could potentially reduce HCV rates in some cities affected by chronic HCV prevalence by half over 15 years.

Some of the earliest results from The Environmental Determinants of Diabetes in The Young (TEDDY) study - a major Europe-USA consortium exploring the causes of type 1 diabetes in children – has found no evidence for viral infection as a cause of the rapid-onset form of the condition.

Ambrisentan should not be used to treat patients for idiopathic pulmonary fibrosis (IPF).

IPF is a fatal form of chronic, progressive lung disease characterized by irreversible scarring around both lungs. IPF causes about 5,000 deaths each year and currently there is no approved treatment. Researchers do not know what causes IPF, but a protein called endothelin-1 that causes the blood vessels to contract and induces lung scarring and proliferation has been associated with the disease.

Minneapolis, MN, May 6, 2013 – Adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been "bridged" toward lung transplantation with novel lung assist devices such as the Novalung. This and related devices work based on pumpless application of oxygenators. A presentation by David M. Hoganson, MD, and colleagues from Washington University School of Medicine in St.

MINNEAPOLIS – Contrary to a widely accepted belief, African-Americans may have a higher rather than lower risk of developing multiple sclerosis (MS) than Caucasians, according to a new study in the May 7, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.

A research letter by Brian Wansink, Ph.D., and Aner Tal, Ph.D., of Cornell University, Ithaca, N.Y., suggests that hungry grocery shoppers tend to buy higher-calorie products.

The research included a laboratory study in which 68 paid participants were asked to avoid eating five hours prior to the study, although during some of the sessions some of the participants were given crackers so they would no longer feel hungry. A follow-up field study tracked the purchases of 82 participants at different times of the day when they were most likely to be full or hungry.

A study by Stephanie Cosentino, Ph.D., of Columbia University, New York, and colleagues examines the relationship between families with exceptional longevity and cognitive impairment consistent with Alzheimer disease. (Online First)

The cross-sectional study included a total of 1,870 individuals (1,510 family members and 360 spouse controls) recruited through the Long Life Family Study. The main outcome measure was the prevalence of cognitive impairment based on a diagnostic algorithm validated using the National Alzheimer's Coordinating Center data set.

The rising cost of Medicare can be cut through strategies such as increasing premiums and raising the eligibility age, but those moves could drive many elderly Americans from the program, leaving them with limited access to health services, according to a new study.

STANFORD, Calif. - Researchers at Stanford University School of Medicine have developed a new technique to see how different types of cells interact in a living mouse. The process uses light-emitting proteins that glow when two types of cells come close together.

DURHAM, N.C. – Continuing analysis of an HIV vaccine trial undertaken in Thailand is yielding additional information about how immune responses were triggered and why the vaccine did not protect more people.

In a study appearing May 6, 2013, in the journal Proceedings of the National Academy of Sciences, an international team of researchers led by the Duke Human Vaccine Institute describe a previously unknown interaction between antibodies that worked to block the vaccine's protective powers.

PITTSBURGH, May 6, 2013 – An ingredient that naturally occurs in breast milk might be used to prevent premature babies from developing a deadly intestinal condition that currently is largely incurable, according to researchers at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC in this week's online early edition of the Proceedings of the National Academy of Sciences.

UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.

The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.