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MUHC researchers identify biomarkers that could leadto early diagnosis of colorectal cancer

This news release is available in French.

Researchers identify way to increase gene therapy success

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

'Molecular Velcro' may lead to cost-effective alternatives to natural antibodies

Taking inspiration from the human immune system, researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have created a new material that can be programmed to identify an endless variety of molecules. The new material resembles tiny sheets of Velcro, each just one-hundred nanometers across. But instead of securing your sneakers, this molecular Velcro mimics the way natural antibodies recognize viruses and toxins, and could lead to a new class of biosensors.

New look at old test may provide earlier detection of meningitis, MU researchers find

COLUMBIA, Mo. ― Researchers from the University of Missouri School of Medicine have found a more accurate method to screen for bacterial meningococcal infection in its early stages, when it's hardest to detect. According to the researchers, the method for diagnosis could save lives by getting patients treatment earlier, when the infection is most treatable.

Autism and language impairment genetically linked

Lorenzo Miodus-Santini an 11-year-old sixth-grader from Princeton, who was classified as autistic at only 13 months old, was never a big talker. As an infant he didn't babble or coo. When he was a toddler beginning to speak, he would learn one word but forget another.

His older brother, Christian, a 15-year-old high school sophomore, shared some similar characteristics – difficulty with reading, processing words and speaking clearly. Doctors said he had language impairments but was not autistic.

Warm winters let trees sleep longer

In the temperate zones, vegetation follows the change of the seasons. After a winter pause, plants put out new growth in spring. Research has now brought a new correlation to light: The colder the winter, the earlier native plants begin to grow again. Since warmer winters can be expected as the climate changes, the spring development phase for typical forest trees might start later and later – giving an advantage to shrubs and invasive trees that don't depend on the cold.

New substance effectively combats multi-resistant bacteria

MULTI-RESISTANCE: In Europe alone, more than 25,000 people die each year from infections caused by multi-resistant bacteria. Researchers from University of Copenhagen have now developed and characterized a substance that quickly and effectively kills the virulent bacteria. The substance employs a multifunctional mechanism that reduces the risk of antibiotic resistance. The findings have recently been published in the scientific journal Chemistry & Biology.

Moral in the morning, but dishonest in the afternoon

Our ability to exhibit self-control to avoid cheating or lying is significantly reduced over the course of a day, making us more likely to be dishonest in the afternoon than in the morning, according to findings published in Psychological Science, a journal of the Association for Psychological Science.

Teenagers and young adults diagnosed with cancer are at increased risk of suicide

Teenagers and young adults are at increased risk of suicide after being diagnosed with cancer according to a study published in the leading cancer journal Annals of Oncology [1] today (Wednesday).

Fertility treatment outcomes can be significantly influenced by mother's ethnicity

Maternal ethnicity is a significant determinant of successful outcomes after fertility treatment, suggests a new study published today (30 October) in BJOG: An International Journal of Obstetrics and Gynaecology.

Researchers, from Nottingham University's Research and Treatment Unit in Reproduction (NURTURE), conducted a study to assess the relationship between the ethnicity of patients and the clinical success of their fertility treatment.

Results from many large clinical trials are never published

CHAPEL HILL, N.C. – A new analysis of 585 large, randomized clinical trials registered with ClinicalTrials.gov finds that 29 percent have not been published in scientific journals. In addition, nearly 78 percent of the unpublished trials had no results available on the website, either.

Exercise programs could help to prevent fall injuries in older people

Exercise programmes designed to prevent falls in older adults also appear to prevent injuries caused by falls, suggests a paper published today on bmj.com.

Fall-related injuries are very common among older people and are a major cause of long-term pain and functional impairment. They also increase the risk of discharge to a nursing home and have a high economic cost.

Unpublished trial data 'violates an ethical obligation' to study participants, say researchers

Almost one in three (29%) large clinical trials remain unpublished five years after completion. And of these, 78% have no results publicly available, finds a study published on bmj.com today.

This means that an estimated 250,000 people have been exposed to the risks of trial participation without the societal benefits that accompany the dissemination of their results, say the authors.

This week in Molecular Biology and Evolution: Honeybee sex!

Everything you wanted to know about honeybee sex

There is an exquisite genetic control behind a honeybee's fate in the hive---from the lowly drone to the almighty queen---which literally, represents the bees knees for evolutionary scientists exploring how multiple mutations, or alleles, of a single gene called the complementary sex determiner (csd) can have a profound influence on honeybee society.

New molecular target for malaria control identified

Malaria is a leading cause of death in tropical and subtropical regions and it is transmitted by a bite from infected female mosquitoes. According to the U.S. Centers for Disease Control, malaria claims nearly 660,000 lives per year, 90% of them in Africa—and most of them children. There were an estimated 216 million malaria cases worldwide in 2010, mostly among pregnant women and children.