Body

Natural selection has altered the appearance of Europeans over the past 5,000 years

There has been much research into the factors that have influenced the human genome since the end of the last Ice Age. Anthropologists at Johannes Gutenberg University Mainz (JGU) and geneticists at University College London (UCL), working in collaboration with archaeologists from Berlin and Kiev, have analyzed ancient DNA from skeletons and found that selection has had a significant effect on the human genome even in the past 5,000 years, resulting in sustained changes to the appearance of people.

JCI online ahead of print table of contents for March 10, 2014

Identification of a broadly neutralizing HIV-1 antibody in a lupus patient

Bread, cereal drive UK children's high salt diet

Children in London eat an unhealthy amount of salt on a daily basis — with much of it coming from breads and cereals, according to new research in the American Heart Association journal Hypertension.

In this London study — so far the largest to measure salt intake in U.K. youth — teens in particular ate more salt each day than is recommended for adults. Cereal- and bread-based products accounted for more than a third, 36 percent, of the salt in children's diets.

New prostate cancer treatment convenient, less expensive, but may be riskier

A faster and less expensive form of radiotherapy for treating prostate cancer may come at a price, according to a new study by Yale School of Medicine researchers — a higher rate of urinary complications.

Research on 3-D scaffolds sets new bar in lung regeneration

In end-stage lung disease, transplantation is sometimes the only viable therapeutic option, but organ availability is limited and rejection presents an additional challenge. Innovative research efforts in the field of tissue regeneration, including pioneering discoveries by University of Vermont (UVM) Professor of Medicine Daniel Weiss, M.D., Ph.D., and colleagues, holds promise for this population, which includes an estimated 12.7 million people with chronic obstructive pulmonary disorder (COPD), the third leading cause of death in the U.S.

Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy

AMHERST, Mass.– Using a new approach to systematically test chemotherapy drugs in an unusual animal model, a research team led by University of Massachusetts Amherst molecular biologist Michele Markstein, with Norbert Perrimon at Harvard Medical School, report that several have a serious side effect: Inducing hyper proliferation in stem cells that could lead to tumor recurrence.

Volcanoes helped species survive ice ages

An international team of researchers has found evidence that the steam and heat from volcanoes and heated rocks allowed many species of plants and animals to survive past ice ages, helping scientists understand how species respond to climate change.

The research could solve a long-running mystery about how some species survived and continued to evolve through past ice ages in parts of the planet covered by glaciers.

Mongol Empire rode wave of mild climate, says study

Researchers studying the rings of ancient trees in mountainous central Mongolia think they may have gotten at the mystery of how small bands of nomadic Mongol horsemen united to conquer much of the world within a span of decades, 800 years ago. The rise of the great leader Genghis Khan and the start of the largest contiguous empire in human history was propelled by a temporary run of nice weather.

Lawn care practices across the nation vary more than expected

BALTIMORE, Md., March 10, 2014 – How people care for urban, suburban and rural lawns – the nation's second biggest crop behind corn – is less consistent than believed, according to scientists with the U.S. Forest Service, Clark University, the Cary Institute of Ecosystem Studies and partners.

In a paper published today by the Proceedings of the National Academy of Sciences, scientists report that fertilizer and lawn irrigation practices by home owners of different age and economic groups varies not only across the nation, but even within the same city.

Shade will be a precious resource to lizards in a warming world

Climate change may even test lizards' famous ability to tolerate and escape the heat -- making habitat protection increasingly vital -- according to a new study by UBC and international biodiversity experts.

Mecasermin (rh-IGF-1) treatment for Rett Syndrome is safe and well-tolerated

(Cincinnati, OH) – The results from Boston Children's Hospital's Phase 1 human clinical trial in Rett syndrome came out today. A team of investigators successfully completed a Phase 1 clinical trial using mecasermin [recombinant human insulin-like growth factor 1 (IGF-1)], showing proof-of-principle that treatments like IGF-1 which are based on the neurobiology of Rett syndrome, are possible.

Ben-Gurion U. researchers identify severe genetic disease prevalent in Moroccan Jews

BEER-SHEVA, Israel, March 10, 2014 - Ben-Gurion University of the Negev (BGU) researchers have unraveled the genetic basis of a hereditary disease that causes severe brain atrophy, mental retardation and epilepsy in Jews of Moroccan ancestry, according to a study published this week online in the Journal of Medical Genetics.

A signal to spread: Wistar scientists identify potent driver of metastasis

An international team of researchers led by scientists at The Wistar Institute have discovered and defined LIMD2, a protein that can drive metastasis, the process where tumors spread throughout the body.

Emergency alert in the cell

This news release is available in German.

Serpentine ecosystems shed light on the nature of plant adaptation and speciation

Plants that live in unusual soils, such as those that are extremely low in essential nutrients, provide insight into the mechanisms of adaptation, natural selection, and endemism. A seminal paper by Arthur Kruckeberg from 1951 on serpentine plant endemism has served as a solid bedrock foundation for future research on the link between natural selection and speciation. A recent article in the American Journal of Botany focuses on how this paper has influenced subsequent research on local adaptation, evolutionary pathways, and the relationship between climate, soils, and endemism.