Body

Researchers have identified a molecular switch that appears to be a common feature in the development of fatty liver disease. The discovery made in mice is consistent with data from human patients, suggesting that it may provide an underlying explanation for the development of fatty liver in people with obesity and metabolic syndrome.

The culprit is the reduced concentration of a little-known transcriptional co-factor known as transducin beta-like (TBL) 1, according to the report in the April issue of Cell Metabolism, a Cell Press publication.

ORLANDO, Fla., April 5, 2011 – Not all cholesterol is bad. Every cell requires it for growth – they either have to get cholesterol somewhere or they die. In a new study published April 6 in the journal Cell Metabolism, researchers from Sanford-Burnham Medical Research Institute (Sanford-Burnham) and their collaborators found that a protein sensor known to balance cholesterol sources can also access a previously underappreciated cellular fat storage depot.

Faced with the prospect of costly in vitro fertilization (IVF) but with no help from insurance coverage, some infertile couples feel pressure to transfer multiple embryos in an attempt to ensure that the IVF is a success. This can lead to higher rates of twin and triplet births and prematurity. But having insurance coverage could curtail the costs associated with these multiple births, according to a new study by researchers at Yale School of Medicine.

For the first time, researchers have found five regions in the human genome that increase susceptibility to immunoglobulin A (IgA) nephropathy, a major cause of kidney failure worldwide — systematically identifying those that point to a tendency for IgA nephropathy, or a protection against it.

Making DNA sequences being passed through nanochannels a thousand times thinner than a human hair to the point that they take on the form of diminutive spaghetti. This is an innovative technique, known as DNA stretching, and is one of the lines of research in which CIC microGUNE is working, and about which they have already published two scientific articles and are shortly to apply for a patent. The technique basically consists of the analysis of a single molecule of DNA, after stretching it, measuring its length and analysing its sequence.

Bremerhaven/Vienna, 05.04.2011. Over the past few days ozone-depleted air masses extended from the north pole to southern Scandinavia leading to higher than normal levels of ultraviolet (UV) radiation during sunny days in southern Finland. These air masses will move east over the next few days, covering parts of Russia and perhaps extend as far south as the Chinese/Russian border. Such excursions of ozone-depleted air may also occur over Central Europe and could reach as far south as the Mediterranean.

Research published in the Cancer Cell journal in March was a significant step in knowing the causes of cancer better, especially breast cancer, revealing that the lack or loss of a protein in the cells known as SIRT3, induces the proliferation of this disease and thereby, this protein can be an may be a therapeutic target in the development of effective therapies for cancer. The research was led by Dra. Marcia Haigis of the Harvard Medical School, with the participation of Dr. Arkaitz Carracedo, from the Proteomics Laboratory at CIC bioGUNE.

MEDFORD/SOMERVILLE, Mass. – Every parent with young children knows that couples need to work together to accomplish the myriad tasks waiting both at work and at home. But it may come as a surprise that fireflies also juggle their commitments to find a comfortable work-family balance. According to new research led by biologists at Tufts University's School of Arts and Sciences, wingless "stay-at-home" female fireflies get less support from their mates than females who are able to fly.

Loss of glaciers and snowpack due to climate warming in alpine regions is putting pressure on a rare aquatic insect, the meltwater stonefly, according to a study recently released in Climatic Change Letters.

New data from the University of Calgary's Faculty of Medicine shows that wait times for a number of heart surgeries have gone down close to 50 per cent in Alberta and British Columbia.

The objective of the study was to investigate wait times for percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery, after the patient has undergone diagnosis through a process called catheterization. PCI's are commonly referred to as balloon angioplasty and CABG's refer to open heart or bypass surgery.

Teenagers who undergo spine fusion for scoliosis using the newest surgical techniques can expect to be doing well 10 years after surgery, according to a Hospital for Special Surgery study published online ahead of print in the [TK issue] of the journal Spine. Researchers had thought that the surgery would cause damage to the spine just below the fused discs, but the study showed that this was not the case.

Women who suffer from asthma or poor lung function as adults generally started their periods at the age of 10 or before. This is the conclusion of a European research study with Spanish participation, which shows that this trend is more common in southern Europe, and particularly affects women from large families.

ORLANDO, FL (April 5, 2011) – Cancer risk increases with age, and scientists have long perceived a possible evolutionary tradeoff between longer lifespan and greater risk of cancer. Now, researchers at Fox Chase Cancer Center find direct evidence for that tradeoff in new data showing that expression of a key tumor suppressor protein induces premature aging in mice.

Greg H. Enders, MD, PhD, associate professor in the Epigenetics and Progenitor Cell Program at Fox Chase, will present the results at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

ORLANDO, FL (April 5, 2011) – Women who have children, particularly early in life, have a lower lifetime risk of breast cancer compared with women who do not. Now, Fox Chase Cancer Center researchers have identified a gene expression pattern in breast tissue that differs between post-menopausal women who had children and post-menopausal women who did not. The results will help scientists understand why pregnancy reduces breast cancer risk and may help them develop chemopreventive strategies that can provide similar protection for women who did not have children.