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New guidelines for cardiovascular genetic testing

An international panel of experts from The Heart Rhythm Society and the European Heart Rhythm Association issued new guideline recommendations for all health care professionals about cardiovascular genetic testing at the Heart Rhythm Society's 32nd Annual Scientific Sessions.

JAMIA reports on people, their information needs and social networks

The May issue of JAMIA, the top-ranked journal reporting on informatics in biomedical and health informatics, features new scientific research—in print and online—on healthcare's hottest HIT-related topics, written by prominent experts working in health and biomedicine. Editor-in chief Lucila Ocho-Machado bullets some of the rich content in the newly released, current issue:

From a bucket of seawater, new understanding of the ocean

NEW BRUNSWICK, N.J. – From a bucket of seawater, scientists have unlocked information that may lead to deeper understanding of organisms as different as coral reefs and human disease. By analyzing genomes of a tiny, single-celled marine animal, they have demonstrated a possible way to address diverse questions such as how diseased cells differ from neighboring healthy cells and what it is about some Antarctic algae that allows them to live in warming waters while other algae die out.

Insight into HIV immunity may lead to vaccine

Latest insights into immunity to HIV could help to develop a vaccine to build antibodies' defences against the disease, a University of Melbourne, Australia study has found.

By investigating the action of the human antibodies called ADCC, in people with HIV, researchers were able to identify that the virus evolves to evade or 'escape' the antibodies.

Pentagonal tiles pave the way towards organic electronics

New research paves way for the nanoscale self-assembly of organic building blocks, a promising new route towards the next generation of ultra-small electronic devices.

UT Southwestern research reveals how cancer-driving enzyme works

DALLAS – May 6, 2011 – Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.

Their latest findings, published today in Molecular Cell, demonstrate that telomerase repairs chromosomes in one of two ways – depending on whether a cell is dividing normally or if the cell is under stress from enzyme inhibition – and could lead to new or improved cancer-fighting therapies that promote inhibition of this enzyme.

Sticking their necks out for evolution: Why sloths and manatees have unusually long (or short) necks

As a rule all mammals have the same number of vertebrae in their necks regardless of whether they are a giraffe, a mouse, or a human. But both sloths and manatees are exceptions to this rule having abnormal numbers of cervical vertebrae. New research published in BioMed Central's open access journal EvoDevo shows how such different species have evolved their unusual necks.

Study adds weight to link between arsenic in drinking water and heart disease

Exposure to even moderate levels of arsenic in drinking water is associated with an increased risk of heart disease, especially among smokers, finds a study published on bmj.com today.

Arsenic is a natural element of the Earth's crust and high concentrations in groundwater pose a public health threat to millions of people worldwide.

Cigarette smoking and arsenic exposure: A deadly combination

Arsenic exposure and smoking each elevate the risk of disease. But when combined together, the danger of dying from cardiovascular disease is magnified, a new study finds.

Exposure to high or even moderate levels of the toxin arsenic through drinking water can elevate the risk of cardiovascular disease mortality, according to a new study published in British Medical Journal. Exposed individuals who smoke were hit with a dangerous double whammy: a combined mortality risk that exceeded the influence of either factor alone.

US medical students are rejecting kidney careers

Kidney disease affects 1 in 9 US adults, and by 2020 more than 750,000 Americans will be on dialysis or awaiting kidney transplant. Despite this growing health problem, every year fewer US medical students adopt nephrology as a career, according to a review appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).

Anatomy of an outbreak

GALVESTON, Texas — What causes a virus to suddenly begin infecting large numbers of people?

Scientists have long known that the process they call "viral emergence" involves a wide variety of factors. Some are changes in the environment, either generated by natural causes or human activity. Others are internal, arising from accidental changes — mutations —in the virus' genetic code.

DNA from common stomach bacteria minimizes effects of colitis, U-M study says

ANN ARBOR, Mich. — DNA from Helicobacter pylori, a common stomach bacteria, minimizes the effects of colitis in mice, according to a new study by University of Michigan Medical School scientists.

Wistar researchers: Direct proof of how T cells stay in 'standby' mode

For much of the time our T cells—the white blood cells that act as the police of the immune system—are in what immunologists call a "quiescent state," a sort of standby mode. For years, scientists have wondered if quiescence occurred by default or whether T cells need to work at remaining silent. Now, researchers at The Wistar Institute provide the first direct proof that a protein, called Foxp1, actively maintains this state of quiescence in T cells until the cells are called upon by other parts of the immune system.

Antibodies help protect monkeys from HIV-like virus, NIH scientists show

WHAT:Using a monkey model of AIDS, scientists have identified a vaccine-generated immune-system response that correlates with protection against infection by the monkey version of HIV, called simian immunodeficiency virus (SIV). The researchers found that neutralizing antibodies generated by immunization were associated with protection against SIV infection.

Selaginella genome adds piece to plant evolutionary puzzle

WEST LAFAYETTE, Ind. - A Purdue University-led sequencing of the Selaginella moellendorffii (spikemoss) genome - the first for a non-seed vascular plant - is expected to give scientists a better understanding of how plants of all kinds evolved over the past 500 million years and could open new doors for the identification of new pharmaceuticals.