Body

The Stowers Institute's Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality of stem cells through intercellular competition. The work was published today by PNAS Early Edition.

PHILADELPHIA - Understanding the molecular signals that guide early cells in the embryo to develop into different organs provides insight into ways that tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure.

INDIANAPOLIS – A multi-center clinical trial led by a Riley Hospital for Children endocrinologist has found that inhaled growth hormone (GH) is well tolerated by children with GH deficiency and that this easy-to-use method can, over a one-week period, safely deliver GH to the blood stream. In addition to having implications for those who need GH, this first pediatric study of administering it through the lungs may also help researchers interested in using this convenient method for effectively delivering other types of medications to children.

Pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). The study identified 27 different genetic regions where rare copy number variations – missing or extra copies of DNA segments – were found in the genes of children with autism spectrum disorders, but not in the healthy controls. The findings are published June 26 in the open-access journal PLoS Genetics.

The thought of coral reefs tends to conjure up images of tropical vacations, complete with snorkeling among tropical fish in crystal clear waters.

Rapid climate change, and increased pollution, ocean acidification and overfishing threaten to darken this picture considerably. These factors heavily stress corals, and thus put both the countless marine organisms that count on corals for habitat and shelter, and the $1 billion dollar tourism industry fueled by coral reefs at significant risk.

PROVIDENCE, R.I. [Brown University] — Staphylococcus epidermidis is quite an opportunist. Commonly found on human skin, the bacteria pose little danger. But S. epidermidis is a leading cause of infections in hospitals. From catheters to prosthetics, the bacteria are known to hitch a ride on a range of medical devices implanted into patients.

We can only marvel at the way that dolphins, whales and porpoises scythe through water. Their finlike flippers seem perfectly adapted for maximum aquatic agility. However, no one had ever analysed how the animals' flippers interact with water; the hydrodynamic lift that they generate, the drag that they experience or their hydrodynamic efficiency. Laurens Howle and Paul Weber from Duke University teamed up with Mark Murray from the United States Naval Academy and Frank Fish from West Chester University, to find out more about the hydrodynamics of whale and dolphin flippers.

Researchers at Radboud University Medical Centre, together with UK Medical Research Council scientists at Oxford University, have uncovered some of the central characteristics of genes underlying mental retardation. The research, which shortens the list of genes whose changes lead to this disorder from thousands to several dozen, is published June 26 in the open-access journal PLoS Genetics.

Scientists at the Gladstone Institutes of Virology and Immunology (GIVI) have found another clue that may lead to eradication of HIV from infected patients who have been on antiretroviral therapy. A real cure for HIV has been elusive because the virus can "hide" in a latent form in resting CD4-T cells. By understanding this "latency" effect, researchers can identify ways to reactivate the virus and enable complete clearance by current or future therapies.

People who eat lots of soy products have better lung function and are less likely to develop the smoking-associated lung disease COPD (Chronic Obstructive Pulmonary Disease). A study published in BioMed Central's open access journal Respiratory Research has shown that consumption of a wide variety of soy products can be associated with a reduction in the risk of COPD and other respiratory symptoms.

The recent decline in invasive breast cancer in the US was significantly less pronounced in the poor and those who live in rural areas. Researchers writing in the open access journal BMC Medicine suggest this may be due to varying reductions in the numbers of women taking hormone therapy (HT).

Christina Clarke, Ph.D., led a team of researchers from the Northern California Cancer Center who studied breast cancer incidence data from the largest cancer database available in the US for the years 1997-2004, comparing poor areas against rich and urban areas against rural.

More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children's Hospital of Philadelphia, the University of Pennsylvania School of Medicine and several collaborating institutions. This study identified 27 different genetic regions where rare copy number variations – missing or extra copies of DNA segments – were found in the genes of children with autism spectrum disorders (ASDs), but not in the healthy controls.

Kidney injury that can arise after undergoing certain medical imaging procedures increases a patient's risk of having a stroke or heart attack over the next year or two, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that seemingly minor and reversible kidney damage from these common clinical procedures is a serious health threat.

Rockville, MD – Like many diseases, causes for age-related macular degeneration (AMD) can be categorized as either "nature" or "nurture". Researchers think these factors, when used in the proper model, can be strong predictors of the disease.

AMD is the leading cause of vision loss in Americans 60 years of age and older.