Body

The "check 'em Tuesday" campaign is a weekly call for women to examine their breasts. Readers are asked to send in photos to prove compliance and can even sign up for a text message reminder.

But Dr McCartney argues that teaching women to examine their breasts regularly "has been shown not to reduce deaths from breast cancer and actually increases the chances of a benign biopsy result." She says it is "unfair to tell women that regular self examination will save their lives when it may simply incur anxiety and have the potential to harm."

Right now, options are limited for preventing heart attacks. However, the day may come when treatments target the heart attack gene, myeloid related protein-14 (MRP-14, also known as S100A9) and defang its ability to produce heart attack-inducing blood clots, a process referred to as thrombosis.

A comprehensive review of 50 year's worth of international studies assessing the benefits and harms of mammography screening suggests that the benefits of the screening are often overestimated, while harms are underestimated. And, since the relative benefits and harms of screening are related to a complex array of clinical factors and personal preferences, physicians and patients need more guidance on how best to individualize their approach to breast cancer screening.

As the climate continues to change, it's unclear to what extent different species will be able to keep pace with altered temperatures and shifted seasons. Living organisms are the survivors of previous environmental changes and might therefore be expected to adapt, but are there limits?

Sleep is essential for human health. But with increasing age, many people experience a decline in sleep quality, which in turn reduces their quality of life. In a new study publishing April 1 in the Open Access journal PLOS Biology, Scientists at the Max Planck Institute (MPI) for Biology of Ageing in Cologne have investigated the mechanisms by which ageing impairs sleep in the fruit fly. Their findings suggest that age-related sleep decline can be prevented and might even be reversible.

How B lymphocytes are able to direct mutations to their antibody genes to produce millions of different antibodies has fascinated biologists for decades. A new study publishing in the Open Access journal PLOS Biology on April 1 by Buerstedde and colleagues shows that this process of programed, spatially targeted genome mutation (aka. somatic hypermutation) is controlled by nearby transcription regulatory sequences called enhancers.

ANN ARBOR, Mich. — Blood transfusions are one of the most common procedures patients receive in the hospital but the more red blood cells they receive, the greater their risk of infection, says a new study led by the University of Michigan Heath System and VA Ann Arbor Healthcare System.

Researchers analyzed 21 randomized controlled trials for the study that appears in today's Journal of the American Medical Association (JAMA).

The vesper bats are the largest and best-known common family of bats, with more than 400 species spread across the globe, ranking second among mammals in species diversity.

Among men undergoing radiation therapy for prostate cancer, daily use of the erectile dysfunction drug tadalafil, compared with placebo, did not prevent loss of erectile function, according to a study in the April 2 issue of JAMA.

Restricting red blood cell (RBC) transfusions among hospitalized patients to those with hemoglobin (the iron-containing protein in RBCs) measures below a certain level is associated with a lower risk of health care-associated infections, according to a study in the April 2 issue of JAMA.

About 40 percent of pharmaceutical company boards of directors examined had at least one member who held a leadership position at an academic medical center, with annual compensation for these positions averaging approximately $300,000, according to a study in the April 2 issue of JAMA.

New research at Washington University School of Medicine in St. Louis and Vanderbilt University Medical Center in Nashville has implicated a poorly understood protein called PLAC8 in the spread of colon cancer.

While elevated PLAC8 levels were known to be associated with colon cancer, the researchers now have shown that the protein plays an active role in shifting normal cells lining the colon into a state that encourages metastasis.

The work appears April 1 in the Journal of Clinical Investigation.

Doctors should focus on life expectancy when deciding whether to order mammograms for their oldest female patients, since the harms of screening likely outweigh the benefits unless women are expected to live at least another decade, according to a review of the scientific literature by experts at UCSF and Harvard medical schools.

This news release is available in German.

This news release is available in German.