In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment.
Vanderbilt-Ingram Cancer Center scientists have now linked a treatment-induced growth factor to the cancer’s future spread.
The team led by Carlos Arteaga, M.D., reports in the May issue of the Journal of Clinical Investigation that radiation and chemotherapy increase circulating levels of the growth factor TGF-beta, circulating cancer cells, and tumor metastases in a mouse model of metastatic breast cancer.