Body

Designing an effective HIV/AIDS vaccine is something of a paradox: a good vaccine would be safe and look enough like HIV to kick-start the immune system into neutralizing the virus – but the problem is that this is exactly what the human immune system has trouble doing even when it's exposed to the real thing.

Boston, Mass., July 18, 2013 - Researchers at Boston Children's Hospital have identified a genetic cause of severe obesity that, though rare, raises new questions about weight gain and energy use in the general obese population. The research, published in the journal Science on July 19, involved genetic surveys of several groups of obese humans and experiments in mice.

You are not just yourself. You are also the thousands of microbes that you carry. In fact, they represent an invisible majority that may be more you than you realize.

These microscopic fellow travelers are collectively called the microbiome. Realization that every species of plant and animal is accompanied by a distinctive microbiome is old news. But evidence of the impact that these microbes have on their hosts continues to grow rapidly in areas ranging from brain development to digestion to defense against infection to producing bodily odors.

CAMBRIDGE, Mass. (July 18, 2013) – Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers. In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug-resistant tumors vulnerable to other therapies.

In an international collaborative project, scientists have recorded the times, places and concentrations of oceanic plankton occurrences worldwide. Their data has been collected in a global atlas that covers organisms from bacteria to krill.

Boston, Mass., July 18, 2012 – Ending a 30-year search by scientists, researchers at Boston Children's Hospital have identified two proteins in the inner ear that are critical for hearing, which, when damaged by genetic mutations, cause a form of delayed, progressive hearing loss. Findings were published online July 18 by the journal Neuron.

Sophia Antipolis, 18 July 2013: A joint consensus statement on the treatment of paediatric arrhythmias has been released by the European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC) and the Association for European Paediatric and Congenital Cardiology (AEPC).

"Pharmacological and non-pharmacological therapy for arrhythmias in the paediatric population" was published in EP-Europace.1

Using an Electronic Health Record (EHR) system to automate the immunization data shared between health providers and public health agencies enables physicians to assist individual patients faster and more effectively, while also providing more immediate, cohesive community data to the agencies tasked with promoting public health.

The results of a major international effort to assess the status of dozens of European fish stocks find that many of those stocks in the northeast Atlantic are being fished sustainably today and that, given time, those populations should continue to recover. The findings, reported in the Cell Press journal Current Biology on July 18, come as surprisingly good news amid widespread criticism that the European Union's Common Fisheries Policy is failing, the researchers say.

We humans can remember events in our lives that happened years ago, with those memories often surfacing unexpectedly in response to sensory triggers: perhaps a unique flavor or scent. Now, researchers reporting in Current Biology, a Cell Press publication, on July 18 have evidence to suggest that chimpanzees and orangutans have similar capacities. In laboratory tests, both primate species were clearly able to recollect a tool-finding event that they had experienced just four times three years earlier and a singular event from two weeks before, the researchers show.

The endoplasmic reticulum (ER) is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. In a study published July 18th by Cell Press in the journal Cell, researchers have refined a new microscopy imaging method to visualize exactly how the ER sheets are stacked, revealing that the 3D structure of the sheets resembles a parking garage with helical ramps connecting the different levels.

CAMBRIDGE, Mass. (July 18, 2013) – Writing in his journal about the scientists of his era, Henry David Thoreau bemoaned their blindness to significant phenomena: "The question is not what you look at, but what you see." More than 150 years later, his words still ring true.

For more than a century, scientists have been peering through microscopes, carefully watching cells divide. Until now, however, none has actually seen how human cells manage to divide into two equally-sized daughter cells during mitosis.

Researchers have created a large new resource of more than 900 genes switched off one-at-a-time in mice to discover which genes are important for a wide range of biological functions such as fertility or hearing.

This resource, known as the Mouse Genetics Project, screens for characteristics and early signs of disease, revealing many new functions for well-known genes, as well as for genes with no previously-known role in disease. Many of these variations in body function are likely to underlie human diseases.

A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases. This finding, published in the July 18 issue of Cell Reports, offers new hope in the battle against a foe that until now has always proved fatal.

Philadelphia, Pa. (July 18, 2013) – Most professional athletes are able to return to competition within a year after vertebral fusion surgery on the upper (cervical) spine, reports a study in the July issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.