Body

NEW YORK (March 25, 2013) -- Two studies led by investigators at Weill Cornell Medical College shed light on the molecular biology of three blood disorders, leading to novel strategies to treat these diseases.

(BOSTON) -- A flame retardant removed from children's pajamas 30 years ago but now used in polyurethane foam is prevalent in office environments, especially in older buildings, where urine testing of workers turned up widespread evidence of its biomarker, a new study led by Boston University School of Public Health researchers has found.

BINGHAMTON, NY – Is there a double standard for gay parents? A new study published this month by a Binghamton University research team suggests that gay parents are being judged more harshly than straight parents.

Irvine, Calif., March 25, 2013 — UC Irvine neurobiologists have found a novel molecular mechanism that helps trigger the formation of long-term memory. The researchers believe the discovery of this mechanism adds another piece to the puzzle in the ongoing effort to uncover the mysteries of memory and, potentially, certain intellectual disabilities.

On the morning of December 6, 1917, in the port of Halifax, Nova Scotia, near the U.S. border in Maine, a French ship, the Mont Blanc, filled with military explosives collided with another vessel. Twenty minutes later, a fire set off the Mont Blanc's volatile cargo and caused a catastrophic explosion—killing thousands and destroying an entire section of the city. Rescue efforts were dispatched immediately from the Canadian mainland as well as the United States, but confusion and lack of immediate information delayed some of the rescue efforts for hours.

Two children with an aggressive form of childhood leukemia had a complete remission of their disease—showing no evidence of cancer cells in their bodies—after treatment with a novel cell therapy that reprogrammed their immune cells to rapidly multiply and destroy leukemia cells. A research team from The Children's Hospital of Philadelphia and the University of Pennsylvania published the case report of two pediatric patients Online First today in The New England Journal of Medicine. It will appear in the April 18 print issue.

Iron is required for multiple cellular functions, including the synthesis of hemoglobin, but a buildup of excess cellular iron can be toxic.

Hepcidin is a circulating molecule produced by the liver that triggers the degradation of iron transporters in the intestine and certain immune cells. In response to rising iron stores, increased hepcidin levels lead to reduced iron absorption from the diet. Iron overload can occur due to inherited mutations in this iron homeostasis pathway, or to disorders that lead to ineffective blood cell development, such as β-thalassemia.

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from sudden unexplained death in epilepsy (SUDEP) compared to patients with other forms of pediatric-onset epilepsy. In this issue of the Journal of Clinical Investigation, Franck Kalume and colleagues at the University of Washington characterized SUDEP in a mouse model of DS.

Reverse cholesterol transport is a process in which accumulated cholesterol is removed from tissues, including the artery wall, and transported back to the liver for excretion. Little is known about how cholesterol is removed from peripheral tissues, but a better understanding of these mechanisms could help in the development of therapies that treat atherosclerosis and other cholesterol-related disorders. In this issue of the Journal of Clinical Investigation, researchers led by Gwendalyn Randolph and colleagues at Washington University in St.

Philadelphia, March 25, 2013 - Two children with an aggressive form of childhood leukemia had a complete remission of their disease-showing no evidence of cancer cells in their bodies-after treatment with a novel cell therapy that reprogrammed their immune cells to rapidly multiply and destroy leukemia cells. A research team from The Children's Hospital of Philadelphia and the University of Pennsylvania published the case report of two pediatric patients Online First today in The New England Journal of Medicine. It will appear in the April 18 print issue.

Collaborating scientists from Nationwide Children's Hospital, Baylor Institute for Immunology Research, and Mount Sinai School of Medicine have identified an important mechanism for stimulating protective immune responses following seasonal influenza vaccinations. The study was published in Science Translational Medicine, a journal of the American Association for the Advancement of Science (AAAS).

While seasonal influenza vaccines protect 60 to 90 percent of healthy adults from "the flu," the mechanisms providing that protection are still not well understood.

Type 1 diabetes is a condition in which the body does not produce insulin and cannot convert sugar, starches and other food into energy. Generally diagnosed during childhood or adolescence, the disease requires lifelong access to medical care and intensive daily self-management.

As children with Type 1 diabetes grow into young adults, they must leave their pediatric health care providers for adult providers. But the timing of this process and its impact on the young people's health had not been fully explored.

WASHINGTON, DC – March 25, 2013 – Mice with different naturally occurring stomach bacteria have distinct susceptibilities to disease caused by Helicobacter pylori, the well-known cause of ulcers in humans, according to a study published online ahead of print in the journal Infection and Immunity. This is the first study to document (in mice) that the presence of certain bacteria in the stomach microbiota can prevent pathology from H. pylori.

CHAPEL HILL, N.C. – Researchers at the University of North Carolina at Chapel Hill have discovered that a protein found in the cells surrounding pancreatic cancers play a role in the spread of the disease to other parts of the body.

Adults in India are substantially more likely to abstain from smoking at home if they are prohibited from smoking at work, a new study has found.

According to data from the Global Adult Tobacco Survey India, 2009/2010, 64 per cent of adults who work in smokefree environments live in a smokefree home, compared with 42 per cent of those who work where smoking is permitted. The proportion of smokefree homes is higher in states with higher proportions of smokefree workplaces.