Body

In poorer countries, young children are more likely to die in the months before their mother's death, when she is seriously ill, and also in the period after her death, according to a study by international researchers published in this week's PLOS Medicine.

These findings are important as they highlight the urgent need for proactive and coordinated community-based interventions to support families, especially vulnerable children, when a mother becomes seriously ill, not just in the period following her death.

Early diagnosis is critical in treating Lyme disease. However, nearly one quarter of Lyme disease patients are initially misdiagnosed because currently available serological tests have poor sensitivity and specificity during the early stages of infection. Misdiagnosed patients may go untreated and thus progress to late-stage Lyme disease, where they face longer and more invasive treatments, as well as persistent symptoms.

Chelation therapy with the drug disodium EDTA has been used for many years with no evidence of efficacy for the treatment of coronary disease, but a randomized trial that included patients with a prior heart attack found that use of a chelation regimen modestly reduced the risk of a composite of adverse cardiovascular outcomes. However, the findings do not support the routine use of chelation therapy for treatment of patients who have had a heart attack, according to a study in the March 27 issue of JAMA.

Among patients with the lung disorder non-cystic fibrosis bronchiectasis, treatment with the antibiotic azithromycin resulted in improvement in symptoms but also increased the risk of antibiotic resistance, according to a study appearing in the March 27 issue of JAMA.

In an examination of a type of treatment for allergic rhinitis and asthma that is used in Europe but not approved by the U.S. Food and Drug Administration, researchers found moderate strength in the evidence from previous studies to support the use of sublingual immunotherapy for the treatment of these conditions, according to an article in the March 27 issue of JAMA. Sublingual immunotherapy involves administration of aqueous allergens under the tongue for local absorption to desensitize the allergic individual over an extended treatment period to diminish allergic symptoms.

PHILADELPHIA—Radiation oncologists at Thomas Jefferson University Hospital are stressing the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients—and with good reason. A new analysis revealed that online dietary recommendations for cancer patients, if even present on an institution's website, appear to be consistently inconsistent.

The nation's 40 federally-funded research and development centers (FFRDCs) spent $17.8 billion on research and development (R&D) in fiscal year (FY) 2011, according to a recent report from the National Science Foundation. More than $850 million of the total was supplied by funds from the American Recovery and Reinvestment Act of 2009.

COLUMBIA, Mo. – Breakfast might be the most important meal of the day, but up to 60 percent of American young people consistently skip it. Now, Heather Leidy, an assistant professor in the Department of Nutrition and Exercise Physiology, says eating a breakfast rich in protein significantly improves appetite control and reduces unhealthy snacking on high-fat or high-sugar foods in the evening, which could help improve the diets of more than 25 million overweight or obese young adults in the U.S.

WINSTON-SALEM, N.C. – March 26, 2013 – A proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women. In Biomaterials, a team from Wake Forest Baptist Medical Center's Institute for Regenerative Medicine report that in the laboratory setting, engineered ovaries showed sustained release of the sex hormones estrogen and progesterone.

Washington, D.C. (March 26, 2013) – Despite some very high-profile female candidates and elected officials, and what looks like a changing landscape of U.S. politics, a new study conducted by American University professor and director of its Women and Politics Institute Jennifer L. Lawless and Richard L. Fox (Loyola Marymount University) reveals that young women are less likely than young men ever to have considered running for office, to express interest in a candidacy at some point in the future, or to consider elective office a desirable profession.

Research from the University of Iowa suggests that cancer care is more accessible in rural areas than thought, and this increased accessibility should be considered as changes are made in the health care system under the Affordable Care Act.

AURORA, Colo. (March 26, 2013) Adolescent type 1 diabetes patients face greater risk for heart attacks, strokes, blindness and kidney failure later in life if their transition from pediatric to adult care is not carefully managed, two CU researchers have found. The estimated median age at transition to adult care was 20.1 years and 77 percent of individuals with type 1 diabetes had left pediatric care by age 21. The study suggests that without support, they were 2.5 times more likely to have high blood glucose levels when transitioning from pediatric to adult care

PHILADELPHIA — A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK--positive non-small cell lung cancer.

The drug, ganetespib, may also be effective for treating patients who have become resistant to the only FDA-approved targeted therapy for this disease, crizotinib, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

PHILADELPHIA — Baldness was associated with an increased risk of prostate cancer among African-American men, and risk for advanced prostate cancer increased with younger age and type of baldness, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

URBANA – In the United States, only species listed on state or federal noxious weed lists are regulated, and those lists are often biased toward species that affect agricultural crops. Conversely, invasive plant council lists include species that affect natural landscapes but have no regulatory clout. After comparing the lists and how they are created, researchers at the University of Illinois's Energy Biosciences Institute have developed some suggestions on how to improve the regulation of all invasive plant species, including new biofuels plants.