Body

Scientists have taken an important step toward a new class of antibiotics aimed at stopping lung infections. They found that a protein found in large airways, called "SPLUNC1," binds to lipids critical to defending against bacterial and viral infections, as well as keeping lung tissue flexible and hydrated. This discovery moves SPLUNC1 closer toward becoming a viable therapy and was reported in the December 2014 issue of The FASEB Journal.

New research involving rats, and published in the December 2014 issue of The FASEB Journal, suggests that if you were born at a low birth weight, supplemental co-enzyme Q (CoQ) may lower your risk for heart disease. This enzyme, which is naturally made in the body, is required to ensure the proper functioning of cell mitochondria and also protects cells from oxidative damage. Feeding low birth weight rat offspring extra CoQ prevented the age-associated damage that causes heart disease.

Conflicting evidence about the extent to which men's semen quality declines with age--likely lowering their fertility--is being cleared up by new University of Otago, New Zealand, research that has collated and reviewed data from 90 previous studies from around the world.

Singapore--Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with local clinicians and colleagues in the USA, have identified a biomarker which is strongly associated with triple negative breast cancer (TNBC), a highly aggressive carcinoma that often has early relapse and metastasis following chemotherapy. The newly identified biomarker, a gene called RASAL2, provides a target for developing new therapeutics designed to treat this often deadly disease.

Personalized medicine uses methods of molecular analysis, especially genetic sequencing and transcription, in order to simultaneously identify genetic mutations to evaluate each individual's risk of contracting a given disease. It seems that there is more than a single mechanism at hand, as proven by the work of a team of geneticists at the University of Geneva's (UNIGE) Faculty of Medicine, and the Swiss Institute for Bioinformatics (SIB).

HOUSTON -- (Dec. 1, 2014) - Most genes are inherited as two working copies, one from the mother and one from the father. However, in a few instances, a gene is imprinted, which means that one copy is silenced. This is called genomic imprinting. If the active copy is mutated, then disease results, even though the silenced gene copy may be normal.

PHILADELPHIA-- Chronic kidney disease (CKD) affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease's progress towards kidney failure. Now, however, a team led by researchers at the Perelman School of Medicine at the University of Pennsylvania, has found an aspect of CKD's development that points to a promising new therapeutic strategy.

A new study* that challenges the prevailing view of how bowel cancer develops in the large intestine is published today in Nature Medicine.

Cancer Research UK scientists have discovered that bowel cancer may not be restricted to starting its journey in the stem cells in the lining of the intestines as previously thought.

This news release is available in French.

Micronutrient malnutrition affects more than 2 billion people. Researchers working at the Crop Development Centre at the University of Saskatchewan are seeking long term solutions to help to alleviate the increasing micronutrient malnutrition problem by enriching food grains with essential micronutrients through breeding and appropriate management practices, collectively known as biofortification.

DARIEN, IL - A new study shows that obstructive sleep apnea is associated with impaired exercise capacity, which is an indicator of increased cardiovascular risk.

Results show that the predicted peak oxygen uptake, a measure of aerobic physical fitness, was significantly lower in people with moderate to severe obstructive sleep apnea than in controls. Further analysis found that sleep apnea severity alone explained 16.1 percent of this variability.

Obese patients who have undergone bariatric surgery to shed weight should take the supplements prescribed to them to protect their eyes. Taking in too little Vitamin A, in particular, could in some cases actually cause night blindness, dry eyes, corneal ulcers, and in extreme cases total blindness. This advice comes from Rui Azevedo Guerreiro and Rui Ribeiro of the Centro Hospitalar de Lisboa Central in Portugal, who reviewed what little research there currently is on the occurrence of eye conditions following bariatric surgery.

Today, ray-finned fish, which belong to the bony fish, are by far the most biodiverse fish group in both salt- and freshwater. Their spectacular variety of forms ranges from eels, tuna, flounders and angler fish all the way to seahorses. With around 1,100 species, the second most biodiverse group is the cartilaginous fish, which are almost exclusively marine and include sharks, rays and chimaeras.

This news release is available in German.

Mate choice is often the most important decision in the lives of humans and animals. Scientists at the Konrad Lorenz Institute of Ethology at the Vetmeduni Vienna have found the first evidence that birds may choose their mate through odor. They published their findings in Nature's Scientific Reports.

Current data bases hold information on thousands of molecules--including drugs, natural substances, and chemical agents found in the environment-- that are associated with diseases, either because they have adverse effects or exert a therapeutic action. Using this information, gathered over many years and available in data bases, scientists headed by ICREA researcher Patrick Aloy at the Institute for Research in Biomedicine (IRB Barcelona) have devised a predictive model that allows them to associate chemical fragments with positive or negative effects in 20% of human diseases.