Body

DALLAS – April 17, 2013 – Researchers at UT Southwestern Medical Center have identified a specific gene that regulates the heart's ability to regenerate after injuries.

The function of the gene, called Meis1, in the heart was not known previously. The findings of the UTSW investigation are available online in Nature.

Equipped with the zebrafish genome, researchers have designed a method to assay the function of each and every gene and to explore the effects genetic variation has on zebrafish. So far the team has generated one or more mutations in almost 40% of all zebrafish genes.

The resource will be a comprehensive catalogue of how changes to our genes can have physical and biochemical consequences, giving other researchers the tools to understand human disease.

Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. Their study highlights the importance of zebrafish as a model organism for human disease research.

An historic fish, with an intriguing past, now has had its genome sequenced, providing a wealth of information on the genetic changes that accompanied the adaptation from an aquatic environment to land. A team of international researchers led by Chris Amemiya, PhD, Director of Molecular Genetics at the Benaroya Research Institute at Virginia Mason (BRI) and Professor of Biology at the University of Washington, will publish "The African coelacanth genome provides insights into tetrapod evolution" April 18 as the cover article in Nature.

A new, pre-clinical study by researchers at Virginia Commonwealth University Massey Cancer Center suggests that a novel drug combination could lead to profound leukemia cell death by disrupting the function of two major pro-survival proteins. The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K/AKT/mTOR, upon which the leukemia cells have become dependent.

The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells. The findings, discovered by researchers in molecular microbiology and immunology at the Keck School of Medicine of USC, hold promise for the development of therapies to fight a variety of viral infections.

Philadelphia, PA, April 17, 2013 – Over 40,000 people die each year in the United States from influenza-related diseases. In patients whose immune systems are compromised, antiviral therapy may be life-saving, but it needs to be initiated quickly. It is therefore crucial to diagnose and type the influenza rapidly. Scientists in the Netherlands have designed and evaluated a set of molecular assays that they say are a sensitive and good alternative for conventional diagnostic methods and can produce results in one day without the need for additional equipment.

COLUMBUS, Ohio – The workers who may have the most to gain from attending company social events may be the ones who actually get the least value from them, a new study suggests.

Researchers found that, in general, workers tended to report closer relationships with their colleagues the more that they attended company social events and shared their nonwork lives with their co-workers.

Migraine headaches are a major cause of ill health and a reduced quality of life. Some individuals suffer from a frequent and severe migraine problem which means that they require regular medication to try and prevent them. A new review¹ of the medications, which may help to prevent episodic migraines, appears in the Journal of General Internal Medicine², published by Springer.

Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer treatment that could significantly reduce side effects and the development of treatment resistance compared with traditional chemotherapy.

SEATTLE – Breast cancer survivors are among the women who could most benefit from regular physical activity, yet few meet national exercise recommendations during the 10 years after being diagnosed, according to a study by researchers at Fred Hutchinson Cancer Research Center. Prior studies and available evidence show a strong association between physical activity and reduced mortality, extended survival and higher quality of life among breast cancer survivors. With 2.9 million breast cancer survivors living in the U.S.

Baltimore, MD— Eggs take a long time to produce in the ovary, and thus are one of a body's precious resources. It has been theorized that the body has mechanisms to help the ovary ensure that ovulated eggs enter the reproductive tract at the right time in order to maximize the chance of successful fertilization.

Typing on today's mobile phones and tablets is needlessly slow. One limitation is that the QWERTY layout is ill-suited for tablets and other touch-screen devices when typing with the thumbs. Two-thumb typing is ergonomically very different from typing on a physical keyboard. It has been established that normal users using a QWERTY on a touch-screen device are limited to typing at a rate of around 20 words per minute, which is slow compared to the rates achieved on physical keyboards.

As much as dog owners love their children, they tend to share more of themselves, at least in terms of bacteria, with their canine cohorts rather than their kids.

Today a panel of international experts working in cooperation with the International Osteoporosis Foundation (IOF) have published SCOPE – or Scorecard for Osteoporosis in Europe.

Focusing on key aspects of service provision and uptake, the Scorecard compares how the 27 different countries within the European Union (EU) care for people with osteoporosis to reduce their risk of bone fractures. Fractures, which mostly affect older adults, can result in pain, long-term disability and even premature death.