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WASHINGTON — Continuous infusion of a novel agent not only halted the progression of Ewing sarcoma in rats, while some tumors also regressed to the point that cancer cells could not be detected microscopically, say researchers at Georgetown Lombardi Comprehensive Cancer Center. Their study, which will be presented at the 2013 annual meeting of the American Society of Clinical Oncology, provides pre-clinical evidence necessary to initiate a clinical trial.

PHILADELPHIA – In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers. Results of the study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Sheba Medical Center in Tel Hashomer, Israel, will be presented during the American Society of Clinical Oncology's annual meeting in Chicago in early June (Abstract #11024).

SAN FRANCISCO, May 15, 2013 --African frogs, originally imported for early 20th century pregnancy tests, carried a deadly amphibian disease to the U.S., according to a new study published today in the journal PLOS ONE.

Mosquitoes infected with the malarial parasite Plasmodium falciparum are significantly more attracted to human odors than uninfected mosquitoes, according to research published May 15 in the open access journal PLOS ONE by James Logan and colleagues from the London School of Hygiene & Tropical Medicine, UK.

People suffering from clinical depression express personal goals and reasons for their attainment or failure in less specific terms than people without the disorder. This lack of specificity in representing personal goals may be partially responsible for the motivational deficits seen in these patients, according to research published May 15 in the open access journal PLOS ONE by Joanne Dickson from the University of Liverpool, UK and Nicholas Moberly from the University of Exeter, UK.

STANFORD, Calif. - In a new study, Stanford University School of Medicine researchers provide the first evidence that African clawed frogs in California harbor a deadly fungal infection that is decimating amphibian populations across the globe.

Scientists at the University of California, Davis, detected the H1N1(2009) virus in free-ranging northern elephant seals off the centralCalifornia coast a year after the human pandemic began, according toa study published today, May 15, in the journal PLOS ONE. It is thefirst report of that flu strain in any marine mammal.

Scientists will attempt to find out how malaria parasites manipulate their mosquito hosts after discovering that smell could be a major factor.

In a study published in PLOS ONE today, a team of researchers led by the London School of Hygiene & Tropical Medicine show for the first time that female mosquitoes infected with malaria parasites are significantly more attracted to human odour than uninfected mosquitoes.

Scientists pinpointed areas of the world where Evolutionarily Distinct and Globally Endangered (EDGE) mammals and amphibians occur. Regions containing the highest concentrations of these species are highlighted as global conservation priorities.

The research paper is published today (15th May) in PLOS ONE.

Men often suffer from more severe cases of psoriasis than women, which may explain why the cost of care for men is higher. This is the conclusion of researchers at Sweden's Umeå University in a new study.

It is known that psoriasis affects about as many women as men. However, it has been shown, both in Sweden and internationally, that men receive more frequent and more expensive care for their disease, compared to women.

ITHACA, N.Y. - Clam fossils from the middle Devonian era – some 380 million years ago – now yield a better paleontological picture of the capacity of ecosystems to remain stable in the face of environmental change, according to research published today (May 15) in the online journal PLOS ONE.

Trained to examine species abundance – the head counts of specimens – paleontologists test the stability of Earth's past ecosystems. The research shows that factors such as predation and organism body size from epochs-gone-by can now be considered in such detective work.

Chances are you know how many miles your car logs for each gallon or tankful of gas, but you probably have only a foggy idea of how much energy your house consumes, even though home energy expenditures often account for a larger share of the household budget.

This disparity in useful energy data is just one of several information gaps that must be bridged as the United States transitions towards residences that generate as much energy as they use over the course of a year—so-called net-zero houses.

Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein (HDL) cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.

In addition to changing HDL from "good" to "bad," the inhalation of emissions activates other components of oxidation, the early cell and tissue damage that causes inflammation, leading to hardening of the arteries, according to the research team, which included scientists from UCLA and other institutions.

University of Illinois at Chicago researchers have developed a website that walks healthcare providers through the challenging transition from the current International Classification of Diseases -- ICD-9 -- to the new ICD-10.

Doctors, hospitals and all other healthcare providers have until October 2014 to switch to the new coding system, used to classify every disease or condition and in every aspect of healthcare from ordering supplies to insurance reimbursement.

MINNEAPOLIS – People who have skin cancer may be less likely to develop Alzheimer's disease, according to new research published in the May 15, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. The link does not apply to melanoma, a less common but more aggressive type of skin cancer.