Body

Chlamydia promotes gene mutations

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs.

Berkeley Lab confirms thirdhand smoke causes DNA damage

A study led by researchers from Lawrence Berkeley National Laboratory has found for the first time that thirdhand smoke—the noxious residue that clings to virtually all surfaces long after the secondhand smoke from a cigarette has cleared out—causes significant genetic damage in human cells.

CNIO researchers discover a new gene involved in obesity

The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, a gene that protects telomeres— the ends of chromosomes—after researchers from the Spanish National Cancer Research Centre (CNIO) surprisingly discovered its key role in obesity.

Pistil leads pollen in life-and-death dance

PROVIDENCE, R.I. [Brown University] — Millions of times on a spring day there is a dramatic biomolecular tango where the flower, rather than adorning a dancer's teeth, is the performer. In this dance, the female pistil leads, the male pollen tubes follow, and at the finish, the tubes explode and die. A new paper in Current Biology describes the genetically prescribed dance steps of the pollen tube and how their expression destines the tube for self-sacrifice, allowing flowering plants to reproduce.

That grocery store cabbage is alive

The fruits and vegetables we buy in the grocery store are actually still alive, and it matters to them what time of day it is. The discovery, reported on June 20 in Current Biology, a Cell Press publication, suggests that the way we store our produce could have real consequences for its nutritional value and for our health.

Bugs provide new insights into relationships between animals and bacteria

Scientists have come closer to untangling a unique and intricate relationship between animals and bacteria, providing potential insights into the complex association between humans and the microbes we rely on for our health.

Pluripotent cells from pancreatic cancer cells first human model of cancer's progression

PHILADELPHIA - Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.

Still, researchers and clinicians don't have a non-invasive way to even detect early cells that portent later disease. 'There's no PSA test for pancreatic cancer,' they say, and that's one of the main reasons why pancreatic cancer is detected so late in its course.

Does your salad know what time it is?

Does your salad know what time it is? It may be healthier for you if it does, according to new research from Rice University and the University of California at Davis.

"Vegetables and fruits don't die the moment they are harvested," said Rice biologist Janet Braam, the lead researcher on a new study this week in Current Biology. "They respond to their environment for days, and we found we could use light to coax them to make more cancer-fighting antioxidants at certain times of day." Braam is professor and chair of Rice's Department of Biochemistry and Cell Biology.

Making a beeline for the nectar

Bumblebees searching for nectar go for signposts on flowers rather than the bull's eye. A new study, by Levente Orbán and Catherine Plowright from the University of Ottawa in Canada, shows that the markings at the center of a flower are not as important as the markings that will direct the bees to the center. The work is published online in Springer's journal, Naturwissenschaften - The Science of Nature.

Scientists design a potential drug compound that attacks Parkinson's disease on 2 fronts

JUPITER, FL-- Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found a compound that could counter Parkinson's disease in two ways at once.

In a new study published recently online ahead of print by the journal ACS Chemical Biology, the scientists describe a "dual inhibitor"- two compounds in a single molecule-- that attacks a pair of proteins closely associated with development of Parkinson's disease.

Goal of identifying nearly all genetic causes of deafness is within reach

New Rochelle, NY, June 20, 2013—At least half of all cases of deafness that develop from birth through infancy in developed countries have a genetic basis, as do many cases of later onset progressive hearing loss. To date, at least 1,000 mutations occurring in 64 genes in the human genome have been linked to hearing loss. Next-generation DNA sequencing technologies are enabling the identification of these deafness-causing genetic variants, as described in a Review article in Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Herding cancer cells to their death

June 20, 2013, New York, NY and Oxford, UK — An advanced tumor is a complex ecosystem. Though derived from a single cell, it evolves as it grows until it contains several subspecies of cells that vary dramatically in their genetic traits and behaviors. This cellular heterogeneity is what makes advanced tumors so difficult to treat.

Changing ocean temperatures, circulation patterns affecting young Atlantic cod food supply

Changing ocean water temperatures and circulation patterns have profoundly affected key Northeast U.S. Continental Shelf zooplankton species in recent decades, and may be influencing the recovery of Atlantic cod and other fish stocks in the region.

Critical seconds saved during brain aneurysm procedure with pre-surgery rehearsal

Surgical Theater's Surgical Rehearsal Platform™ (SRP) provided neurosurgeons the opportunity to rehearse a complicated cerebral case before entering the operating room, saving the surgical team critical seconds on a time-sensitive procedure.

Why jumping genes don't send us into meltdown

The study reveals for the first time how the movement and duplication of segments of DNA known as transposons, is regulated. This prevents a genomic meltdown, and instead enables transposons to live in harmony with their hosts — including humans.