Body

August 12, 2013, New York, NY – Loss of a gene required for stem cells in the brain to turn into neurons may underlie the most severe forms of neuroblastoma, a deadly childhood cancer of the nervous system, according to a Ludwig Cancer Research study. Published in Developmental Cell today, the findings also provide clues about how to improve the treatment of this often-incurable tumor.

An international scientific collaborative led by the Harvard Stem Cell Institute's Kornelia Polyak, MD, PhD, has discovered why women who give birth in their early twenties are less likely to eventually develop breast cancer than women who don't, triggering a search for a way to confer this protective state on all women.

New Rochelle, NY -- Body mass index (BMI) or a change in BMI is often the sole measure used to evaluate whether an intervention intended to combat childhood obesity is effective. But a new study clearly shows that an intervention can have beneficial effects on other health outcomes, such as cardiovascular fitness, regardless of its effect on BMI. Focusing on a single factor like the degree of BMI change is restrictive and can overlook other important outcomes, according to an article published in Childhood Obesity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Older male nightingales perform faster and more demanding trills than their younger rivals. These findings were published by researchers at the University of Basel and the Netherlands Institute of Ecology in the online edition of Journal of Avian Biology. With up to 100 trill elements a second, nightingales belong to the fastest singers.

Researchers at the Ruhr-Universität Bochum (RUB) have discovered an efficient process for hydrogen biocatalysis. They developed semi-synthetic hydrogenases, hydrogen-generating enzymes, by adding the protein's biological precursor to a chemically synthesized inactive iron complex. From these two components, the biological catalyst formed spontaneously in a test tube. "Extracting hydrogenases from living cells is highly difficult," says Prof Dr Thomas Happe, head of the work group Photobiotechnology at the RUB. "Therefore, their industrial application has always been a long way off.

A new strategy that dismantles a viral genome in human lung cells will ensure safe research on deadly strains of influenza, say researchers from the Icahn School of Medicine at Mount Sinai.

Details of their "molecular biocontainment" approach, designed to prevent effective transmission of these viruses to humans, are published in Nature Biotechnology.

The strategy they developed and tested will enable healthy molecules in human lung cells to latch on to these viruses and cut the bugs up before they have a chance to infect the human host.

In 1958 a group of scientists working in Denmark made the striking observation that bacterial cells are about twice as large when they are cultured on a rich nutrient source than when they are cultured on a meager one. When they are shifted from a nutrient-poor environment to a nutrient-rich one, they bulk up until they have achieved a size more appropriate to their new growth conditions.

It has taken 60 years to figure out how the bacteria are able to sample their surroundings and alter their cell cycles so that they grow to a size suited to the environment.

HOUSTON -- Rice University researchers are making strides toward a set of rules to custom-design Lego-like viral capsid proteins for gene therapy.

A new paper by Rice scientists Junghae Suh and Jonathan Silberg and their students details their use of computational and bioengineering methods to combine pieces of very different adeno-associated viruses (AAVs) to create new, benign viruses that can deliver DNA payloads to specific cells.

The research appears this month in the American Chemical Society journal ACS Synthetic Biology.

TORONTO, ON, August 12, 2013 – Women who had a colposcopy at a sexual health clinic that provided extra support and counselling were 34 per cent more likely to undergo the cancer screening procedure compared to women who were referred to a hospital or doctor's office, according to a new study by Women's College Hospital's Dr. Sheila Dunn.

It is possible to see how advanced a bowel cancer is by looking at its metabolic 'fingerprint', according to new research.

Bowel cancer is the third most common type of cancer globally, with over one million new cases diagnosed every year. Accurately determining the stage that a tumour has reached is crucial for deciding which treatments to offer.

A new study out of the University of Cincinnati not only finds that parents feel responsible about taking action when their children struggle with social issues, but also that parents are influenced by their own childhood memories. Jennifer Davis Bowman, a recent graduate of the special education doctoral program at the University of Cincinnati, will present her research on Aug. 12, at the 108th annual meeting of the American Sociological Association in New York, N.Y.

Humans originated in Africa. But what route did they take as they began to disperse around the world 60,000 years ago? A new professor at the University of Huddersfield has played a key role in finding the answer to one of the most fundamental questions in the history of mankind.

A Professor from The University of Manchester has had his name immortalised as a new species of fly.

Professor Richard Preziosi, from the Faculty of Life Sciences, said he was delighted with the unusual tribute from researcher Dr. Dave Penney.

It follows his continued support of Dr. Penney's unfunded research into amber rocks which he has been investigating for around 20 years.

The relationship between body mass index (BMI) appears to be stronger in adults without diabetes than those with existing diabetes. These findings¹ are published in the Journal of General Internal Medicine² in a study by Chandra Jackson of the Harvard School of Public Health and colleagues. The researchers suggest that studies on body weight and mortality should take into account the impact of diabetes status in the population.

Some patients with a rare type of epilepsy called epilepsy aphasia have something else in common. They have mutations in the same gene. Epilepsy aphasia disorders are characterized by seizures and speech abnormalities.

University of Washington researchers headed a recent study on genetic association. Their report, "GRIN2A mutations cause epilepsy-aphasia spectrum disorders," is published in the Aug. 11 issue of Nature Genetics.