Body

Screening with low-dose spiral CT scanning reduces lung cancer deaths by 20 percent

Current or heavy smokers who were screened with low-dose spiral computed tomography (CT) scanning had a 20 percent reduction in deaths from lung cancer than did those who were screened by chest X-ray, according to results from a decade-long, large clinical trial that involved more than 53,000 people.

UT MD Anderson debuts lung cancer screening program

HOUSTON - Current and former heavy smokers can now be screened more effectively for lung cancer. Results from the National Lung Screening Trial (NLST) revealed that detecting small lung cancers with computed tomography (CT) reduces lung cancer specific mortality by 20 percent.

New therapy for childhood neuroblastoma proves feasible and safe

Reston, Va. (June 29, 2011) – A new treatment option may soon be available for children with neuroblastoma according to research published in the July issue of The Journal of Nuclear Medicine. The study tested the principle that combined positron emission tomography and X-ray computed tomography (PET/CT) may be used to select children with primary refractory or relapsed high-risk neuroblastoma for treatment with a molecular radiotherapy known as 177Lu-DOTATATE. This therapeutic option was found to be viable option for children with neuroblastomas.

Money and mimicry

"Money, money, moneyMust be funnyMoney, money, moneyAlways sunnyIn the rich man's world."-ABBA, 1976

We rely on money in our day-to-day life and it is constantly in our minds. After all, money makes the world go round, doesn't it? Now, a new study, which will be published in an upcoming issue of Psychological Science, a journal of the Association for Psychological Science, tries to better understand the psychological effect of money and how it affects our behavior, feelings and emotions.

Girl's Puberty Book Project provides an international model for promoting female health in Africa

June 29, 2011 -- The onset of puberty is a critical moment for reaching girls with health messages and information, and the stakes are particularly high in countries where the HIV/AIDS epidemic rages and where threats to female reproductive health abound. Yet to date, the healthcare community in low-resource countries has tended to neglect this opportunity and instead concentrate efforts on young women who are older and of reproductive age.

Research finding suggests way to make bladder cancer cells more susceptible to chemotherapy

(SACRAMENTO, Calif.) — Researchers at the UC Davis Cancer Center have discovered a way of sensitizing muscle-invasive bladder cancer cells so that they succumb to the toxic effects of chemotherapy. The finding adds to mounting evidence that tiny strands of RNA — called microRNA — play key roles in some of the deadliest types of cancer.

Blocking molecular target could make more cancers treatable with PARP inhibitors

BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs.

Currently, the role of PARP inhibitors has mainly been restricted to cancers whose cells lack functioning versions of the damage-repair proteins BRCA1 or BRCA2 -- chiefly certain breast and ovarian cancers.

A role for glia in the progression of Rett syndrome

A paper published online today in Nature reveals that glia play a key role in preventing the progression of the most prominent Rett Syndrome symptoms displayed by mouse models of the disease: lethality, irregular breathing and apneas, hypoactivity and decreased dendritic complexity. The discovery, funded in part by the Rett Syndrome Research Trust (RSRT) was led by Gail Mandel, Ph.D., an investigator of the Howard Hughes Medical Institute at Oregon Health and Science University.

Scientists identify order of mutations that lead to cancer

PHILADELPHIA — Scientists have begun to reveal the order of the genetic aberrations in individual cancers in a finding they say is key to early diagnosis and personalized medicine.

"We know that each cancer is a collection of genetic malfunctions," said Raymond Cho, Ph.D., an assistant clinical professor in the department of dermatology at the University of California, San Francisco (UCSF). "We now show it is possible to determine which changes happen earlier and which ones happen further down the road, even in a single cancer."

Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment

HOUSTON -- (June 30, 2011) –The genome of the most common form of ovarian cancer is characterized by a few common gene mutations but also surprisingly frequent structural changes in the genome itself, said members of The Cancer Genome Atlas (http://cancergenome.nih.gov/), including the Baylor College of Medicine (www.bcm.edu) Human Genome Sequencing Center (www.hgsc.bcm.tmc.edu/), that sequenced and analyzed more than 300 such t

Case Western Reserve researchers identify HIV-inhibiting mechanism

CLEVELAND – June 29, 2011 –Researchers at Case Western Reserve University School of Medicine have discovered a long-sought cellular factor that works to inhibit HIV infection of myeloid cells, a subset of white blood cells that display antigens and hence are important for the body's immune response against viruses and other pathogens.

The Cancer Genome Atlas completes detailed ovarian cancer analysis

An analysis of genomic changes in ovarian cancer has provided the most comprehensive and integrated view of cancer genes for any cancer type to date. Ovarian serous adenocarcinoma tumors from 500 patients were examined by The Cancer Genome Atlas (TCGA) Research Network and analyses are reported in the June 30, 2011, issue of Nature.

New fossils demonstrate that powerful eyes evolved in a twinkling

Palaeontologists have uncovered half-a-billion-year-old fossils demonstrating that primitive animals had excellent vision.

An international team led by scientists from the South Australian Museum and the University of Adelaide found the exquisite fossils, which look like squashed eyes from a recently swatted fly.

New salmonella-based 'clean vaccines' aid the fight against infectious disease

A powerful new class of therapeutics, known as recombinant attenuated Salmonella vaccines (RASV), holds great potential in the fight against fatal diseases including hepatitis B, tuberculosis, cholera, typhoid fever, AIDS and pneumonia.

Men play post-op catch-up

Although women generally have worse knee function and more severe symptoms before undergoing surgery for knee replacement than men, they recover faster after the operation. Men take longer to recover but, after a year, they catch up with women and there are no differences in surgery outcomes at that time. These findings by Thoralf Liebs, from Hassenpflug University of the Schleswig-Holstein Medical Center in Germany, and colleagues, are published online in Springer's journal Clinical Orthopaedics and Related Research.