Thirty years ago, and a quarter of a century after randomized trials had become widely accepted, Archie Cochrane reproached the medical profession for not having critical summaries of all randomized controlled trials. At that time, there were about 14 reports of trials published per day.
There are now 75 clinical trials and 11 systematic reviews of trials published every day, with no signs of slowing. How will researchers cope with the volume and the continued poor quality of many of these studies, ask a group in PLoS Medicine.