New York, NY (September 25, 2012) — Researchers in the Taub Institute at Columbia University Medical Center (CUMC) have identified a mechanism that appears to underlie the common sporadic (non-familial) form of Parkinson's disease, the progressive movement disorder. The discovery highlights potential new therapeutic targets for Parkinson's and could lead to a blood test for the disease. The study, based mainly on analysis of human brain tissue, was published today in the online edition of Nature Communications'.
Brain
A strong democracy depends on smart voters who choose their leaders based on their knowledge of important political issues. One of the ways that Americans learn about politics is by following the news. Now, researchers from the University of Missouri School of Journalism have found that simply following the news is not enough.
September 25, 2012
A new video protocol in Journal of Visualized Experiments (JoVE) details an assay to identify brain tumor initiating stem cells from primary brain tumors. Through flow cytometry, scientists separate stem cells from the rest of the tumor, allowing quick and efficient analysis of target cells. This approach has been effectively used to identify similar stem cells in leukemia patients.
Researchers in Georgia Tech's Center for Behavior Imaging have developed two new technological tools that automatically measure relevant behaviors of children, and promise to have significant impact on the understanding of behavioral disorders such as autism.
Are the longevity and vitality of traditional Chinese medicine (TCM) due to its holistic approach? Indeed, Chinese medicine is not simply about treating illness, but rather about taking care of the whole person—body, mind, and spirit. According to an analysis¹ of TCM's origins and development by Lin Shi from Beijing Normal University and Chenguang Zhang from Southwest Minzu University in China, traditional Chinese medicine is profoundly influenced by Chinese philosophy and religion. To date, modern science has been unable to explain the mechanisms behind TCM's effects.
Los Angeles (September 25, 2012)- With ties to diabetes, hypertension, and high cholesterol, childhood obesity in wealthy countries is certainly of growing concern to researchers. A new study explores the ties between childhood weight problems, socioeconomic status, and nationality and finds that race, ethnicity, and immigrant status are risk factors for weight problems among children in the US and England.
WASHINGTON—Research comparing brain development in humans and our closest nonhuman primate relatives, chimpanzees, reveals how quickly myelin in the cerebral cortex grows, shedding light on the evolution of human cognitive development and the vulnerability of humans to psychiatric disorders, a GW professor finds. Myelin is the fatty insulation surrounding axon connections of the brain.
Although they're a common nuisance in the home, fruit flies have made great contributions to research in genetics and developmental biology. Now a Tel Aviv University researcher is again turning to this everyday pest to answer crucial questions about how neurons function at a cellular level — which may uncover the secrets of neurological disorders such as Alzheimer's disease.
Irvine, Calif. — American and European scientists have found that increasing natural marijuana-like chemicals in the brain can help correct behavioral issues related to fragile X syndrome, the most common known genetic cause of autism.
The work indicates potential treatments for anxiety and cognitive defects in people with this condition. Results appear online in Nature Communications.
LA JOLLA, Calif., September 25, 2012 – The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To speed things up, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) turned to kinase inhibitors. These chemical compounds block the activity of kinases, enzymes responsible for many aspects of cellular communication, survival, and growth.
BACKGROUND
In the Alzheimer's brain, hard plaques accumulate between the nerve cells while twisted fibers grow inside the nerve cells. The plaques arise from protein fragments called beta amlyoid, and the fibers form from a protein called tau. Doctors rely on brain scans to detect amyloid and tau and provide early intervention and treatment to potentially slow or reverse disease progression.
FINDINGS
CHICAGO – A medical record review study of 97 patients with the fatal, degenerative brain disorder sporadic Jakob-Creutzfeldt disease (sCJD) suggests that a correct diagnosis of the disease was often delayed by a variety of misdiagnoses, according to a report published Online First by Archives of Neurology, a JAMA Network publication.
Cold Spring Harbor, NY – A team of neuroscientists and chemists from the U.S. and China today publish research suggesting that a class of currently used anti-cancer drugs as well as several previously untested synthetic compounds show effectiveness in reversing memory loss in two animal models of Alzheimer's' disease.
CSHL Professor Yi Zhong, Ph.D., who led the research conducted in fruit flies and mice, says he and his colleagues were surprised with their results, which, he stressed, used two independent experimental approaches "the results of which clearly converged."
Most people equate "gray matter" with the brain and its higher functions, such as sensation and perception, but this is only one part of the anatomical puzzle inside our heads. Another cerebral component is the white matter, which makes up about half the brain by volume and serves as the communications network.
September 24, 2012 - People often remark that people of a different race "all look alike." However, when we have trouble recognizing people from another race, it may actually have little to do with the other person's race. Instead, new research finds that that we can improve our memory of members of another race by identifying ourselves as part of the same group. Such identification could improve everything from race relations to eyewitness identification.