Durham, NC — A new study of a devastating bird disease that spread from poultry to house finches in the mid-1990s reveals that the bacteria responsible for the disease evolves at an exceptionally fast rate. What's more, the fast-evolving microbe has lost a key chunk of its genome since jumping to its new host, scientists were surprised to find. The missing portion contained the genes that made up the microbe's immune system, researchers report in the February 9th issue of PLoS Genetics.
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New research suggests that unrelated individuals may be mistakenly identified as genetic family members due to inaccurate genetic assumptions. This is particularly relevant when considering familial searching: a new technique which extends forensic identification to family members of individuals with profiles in offender/arrestee DNA databases.
A study of almost 3,800 pregnancies has provided the most accurate and direct evidence to date that malaria infection reduces early foetal growth. Low birth weight is the most important risk factor for neonatal mortality in developing countries. The research, carried out on the border of Thailand and Myanmar (Burma), highlights the importance of preventing malaria in pregnancy.
A new study combines genetic and neurobiological approaches to confirm that synaptic mutations increase the risk of autism spectrum disorders (ASDs). It also highlights a role for modifier genes in these disorders. Published in PLoS Genetics, this research was conducted by researchers at the Institut Pasteur, the Paris Diderot University, the Robert Debré Hospital, the Gillberg Neuropsychiatry centre, Ulm University and the Centre National de Génotypage, in collaboration with other institutions in Europe.
Scientists from Queen Mary, University of London have discovered the workings behind some of the bacteria that kill hundreds of thousands every year, possibly paving the way for new antibiotics that could treat infections more effectively.
With antibiotic resistance on the rise in strains of pathogenic bacteria, innovative strategies are needed to discover ways of treating bacterial infections in both humans and in agriculture.
RIVERSIDE, Calif. — An international research team led by cell biologists at the University of California, Riverside has uncovered a new insight into colon cancer, the third leading cause of cancer-related deaths in the United States. The research provides potential new avenues for diagnosing and treating the disease.
The emerald ash borer, Agrilus planipennis (Fairmaire), an invasive insect from Asia which was first found in the U.S. in the 1990s, has since spread to 15 states and is responsible for the deaths of millions of ash trees. This insect has the potentionl to kill billions more trees and to do several billions of dollars worth of damage.
Scientists at the University of California, San Diego have developed a new method for making scaffolds for culturing tissue in three-dimensional arrangements that mimic those in the body. This advance, published online in the journal Advanced Materials, allows the production of tissue culture scaffolds containing multiple structurally and chemically distinct layers using common laboratory reagents and materials.
DALLAS (Feb. 9, 2012) — In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in Dallas, Texas, researchers will report findings that suggest that delivery by cesarean section may not be protective compared to vaginal deliveries for babies who are small for their gestational age (those weighing less than the 10th percentile at birth based on national growth curves) born more than six weeks before their due date.
NEW YORK -- A nationwide, federally funded study has found that testing a developing fetus' DNA through chromosomal microarray (CMA) provides more information about potential disorders than does the standard method of prenatal testing, which is to visually examine the chromosomes (karyotyping). The results of the 4,000-plus-participant clinical study are being presented at the 32nd annual meeting of the Society for Maternal-Fetal Medicine in Dallas on Feb. 9, 2012. The study was recently published in the American Journal of Obstetrics & Gynecology.
JUPITER, FL -- Scientists from the Florida campus of The Scripps Research Institute have identified a single prion protein that causes neuronal death similar to that seen in "mad cow" disease, but is at least 10 times more lethal than larger prion species.This toxic single molecule or "monomer" challenges the prevailing concept that neuronal damage is linked to the toxicity of prion protein aggregates called "oligomers."
The study was published this week in an advance, online edition of the journal Proceedings of the National Academy of Sciences.
A technique for creating a new molecule that structurally and chemically replicates the active part of the widely used industrial catalyst molybdenite has been developed by researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). This technique holds promise for the creation of catalytic materials that can serve as effective low-cost alternatives to platinum for generating hydrogen gas from water that is acidic.
LA JOLLA, CA – Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape. Ultraviolet (UV) radiation from the sun can damage proteins and DNA inside cells, leading to poor growth and even death (as well as carcinogenesis in humans). But plants have evolved some powerful adaptive defenses, including a complex array of protective responses orchestrated by a UV-sensing protein molecule known as UVR8.
DALLAS, Feb. 9, 2012 – The widely-held assumption that a cesarean delivery has no health risks for the baby is being challenged today by new research that found the procedure did not help some preterm babies who were small for gestational age, and may even have contributed to their breathing problems.
A recent large and comprehensive analysis of 50,000 genetic variants across 2,000 genes linked to cardiovascular and metabolic function has identified four genes associated with type 2 diabetes (T2D) and six independent disease-associated variants at previously known loci. The findings, which provide valuable insight into the genetic risk for T2D across multiple ethnicities, add to the growing list of genetic variants that affect the risk of developing T2D and could pave the way for identification of valuable drug targets.