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Follow-up study describes declining efficacy of malaria vaccine candidate over 4 years

Long-term follow-up of a phase II study from KEMRI-Wellcome Trust Research Programme and Oxford University researchers in Kenya shows that the efficacy of a malaria vaccine candidate, RTS,S, wanes over time and varies with exposure to the malaria parasite.

The findings will help to inform which populations are likely to benefit most from the vaccine candidate. They also have important implications for the design of future clinical trials of this and other vaccine candidates and highlight the importance of long-term follow-up studies for assessing vaccine efficacy.

Study reveals potential immune benefits of vitamin D supplements in healthy individuals

(Boston) – Research from Boston University School of Medicine (BUSM) shows that improving vitamin D status by increasing its level in the blood could have a number of non-skeletal health benefits. The study, published online in PLOS ONE, reveals for the first time that improvement in the vitamin D status of healthy adults significantly impacts genes involved with a number of biologic pathways associated with cancer, cardiovascular disease (CVD), infectious diseases and autoimmune diseases.

Maternal diabetes impairs methylation of imprinted gene in oocytes

For the first time, researchers have shown that poorly controlled maternal diabetes has an adverse effect on methylation of the maternal imprinting gene Peg3, contributing to impaired development in offspring.

New imaging agent enables better cancer detection, more accurate staging

Researchers at the University of California, San Diego School of Medicine have shown that a new imaging dye, designed and developed at UC San Diego Moores Cancer Center, is an effective agent in detecting and mapping cancers that have reached the lymph nodes. The radioactive dye called Technetium Tc-99m tilmanocept, successfully identified cancerous lymph nodes and did a better job of marking cancers than the current standard dye. Results of the Phase III clinical trial published online today in the Annals of Surgical Oncology.

Sustainable Development Goals must sustain people and planet

In the wake of last week's meetings at the UN on the definition of the Sustainable Development Goals (SDGs), a group of international scientists have published a call in the journal Nature today, arguing for a set of six SDGs that link poverty eradication to protection of Earth's life support. The researchers argue that in the face of increasing pressure on the planet's ability to support life, adherence to out-dated definitions of sustainable development threaten to reverse progress made in developing countries over past decades.

Baffling blood problem explained

In the early 1950's, a 66-year-old woman, sick with colon cancer, received a blood transfusion. Then, unexpectedly, she suffered a severe rejection of the transfused blood. Reporting on her case, the French medical journal Revue D'Hématologie identified her as, simply, "Patient Vel."

After a previous transfusion, it turns out, Mrs. Vel had developed a potent antibody against some unknown molecule found on the red blood cells of most people in the world—but not found on her own red blood cells.

Teen mentors inspire healthier choices in younger children

COLUMBUS, Ohio – An obesity intervention taught by teen mentors in Appalachian elementary schools resulted in weight loss, lower blood pressure and healthy lifestyle changes among the younger students learning the curriculum, according to a new study.

In contrast, children taught the same lessons by adults in a traditional classroom saw no changes in their health outcomes.

NIH-supported researchers identify new class of malaria compounds

A group of researchers from 16 institutions around the world has identified a new class of anti-malarial compounds that target multiple stages of the malaria parasite's life cycle (http://www.niaid.nih.gov/topics/malaria/pages/lifecycle.aspx). These compounds could potentially be developed into drugs that treat and prevent malaria infection.

University of South Florida researchers play key role in discovery of new drug to combat malaria

Tampa, FL (March 20, 2013) -- University of South Florida researchers played a key role in an international multidisciplinary project that has yielded a promising new antimalarial drug with the potential to cure the mosquito-borne disease and block its transmission with low doses.

Roman Manetsch, PhD, USF associate professor of chemistry, and Dennis Kyle, PhD, USF professor of global health, were co-leaders of the USF team, which helped to discover and develop a series of potent compounds to combat malaria known as the 4-(1H)-quinolone-3-diarylethers, or quinolones.

Roads could help rather than harm the environment, say experts

Two leading ecologists say a rapid proliferation of roads across the planet is causing irreparable damage to nature, but properly planned roads could actually help the environment.

"Loggers, miners and other road builders are putting roads almost everywhere, including places they simply shouldn't go, such as wilderness areas," said Professor Andrew Balmford of the University of Cambridge, UK. "Some of these roads are causing environmental disasters."

Biodiversity does not reduce transmission of disease from animals to humans

More than three quarters of new, emerging or re-emerging human diseases are caused by pathogens from animals, according to the World Health Organization.

But a widely accepted theory of risk reduction for these pathogens – one of the most important ideas in disease ecology – is likely wrong, according to a new study co-authored by Stanford Woods Institute for the Environment Senior Fellow James Holland Jones and former Woods-affiliated ecologist Dan Salkeld.

Computers predict basketball national championship

When Georgia Tech opens the doors to the Georgia Dome next month as the host institution for the 2013 Final Four, expect third-seeded Florida to walk out as the national champion. That's the prediction from Georgia Tech's Logistic Regression/Markov Chain (LRMC) college basketball ranking system, a computerized model that has chosen the men's basketball national champ in three of the last five years.

UC Davis research advances efforts to prevent dangerous blood clots

(SACRAMENTO, Calif.) -- New research from the UC Davis Comprehensive Cancer Center, published in the Journal of Surgical Research, may help clinicians determine which patients are at highest risk for post-surgical blood clots in the legs or lungs.

Some Alaskan trout use flexible guts for the ultimate binge diet

Imagine having a daylong Thanksgiving feast every day for a month, then, only pauper's rations the rest of the year.

University of Washington researchers have discovered Dolly Varden, a kind of trout, eating just that way in Alaska's Chignik Lake watershed.

Organs such as the stomach and intestines in the Dolly Varden doubled to quadrupled in size when eggs from spawning sockeye salmon became available each August, the researchers found. They were like vacuums sucking up the eggs and nipping at the flesh of spawned-out salmon carcasses.

Insights into the immune system, from the fates of individual T cells

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled. The crucial question: What determines which of the immune system's millions of cells will mobilize to fight an acute infection and which will be held back to survive long-term, forming the basis of the immunological memory? The scientists' findings, published in the journal Science, could have implications for improved immunotherapy and vaccination strategies.