Body

Alexandria, VA, March 21, 2013 — A New England Journal of Medicine (NEJM) study showing that physical therapy is just as effective as surgery in patients with meniscal tears and arthritis of the knee should encourage many health care providers to reconsider their practices in the management of this common injury, according to the American Physical Therapy Association (APTA).

Dr Shelby Temple, now at the University of Bristol, and his team at the University of Queensland and the University of Western Australia used a modified version of the Landolt C test to discover just how fine a detail the archerfish could resolve.

The researchers first trained the fish to spit at one of two letters – an 'O' or a 'C' – by rewarding them with food. Then they showed them small versions of both letters together and recorded which letter they spat at.

Illnesses caused by many of the world's most deadly viruses cannot be effectively treated with existing drugs or vaccines. A study published by Cell Press in the March 21 issue of the journal Chemistry & Biology has revealed several compounds that can inhibit multiple viruses, such as highly lethal Ebola virus, as well as pathogens responsible for rabies, mumps, and measles, opening up new therapeutic avenues for combating highly pathogenic viruses.

In infected individuals, HIV mutates rapidly to escape recognition by immune cells. This process of continuous evolution is the main obstacle to natural immunity and the development of an effective vaccine. A new study published by Cell Press in the March 21 issue of the journal Immunity reveals that the immune system has the capacity to adapt such that it can recognize mutations in HIV. The findings suggest that our immune cells' adaptability could be harnessed to help in the fight against AIDS.

JUPITER, FL – March 21, 2013 – Researchers at The Scripps Research Institute (TSRI) in Jupiter, FL, have developed cutting-edge technology that can successfully screen human blood for disease markers. This tool may hold the key to better diagnosing and understanding today's most pressing and puzzling health conditions, including autoimmune diseases.

(Boston) – Researchers at Boston University School of Medicine (BUSM) have identified a new chemical class of compounds that have the potential to block genetically diverse viruses from replicating. The findings, published in Chemistry & Biology, could allow for the development of broad-spectrum antiviral medications to treat a number of viruses, including the highly pathogenic Ebola and Marburg viruses.

COLUMBIA, Mo. – Every community in America has its share of parks. However, park amenities in certain communities can be lacking, which can be detrimental to the health of potential patrons. Now, a University of Missouri researcher has found that while more parks exist in lower-income neighborhoods, they tend to be less attractive than parks in upper- and middle-class neighborhoods, which have more amenities and are more visually pleasing.

Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in the Jan. 16 issue of The Breast Journal.

Boston – In a highly anticipated report, landmark recommendations on the handling of incidental findings in clinical genome and exome sequencing are being issued from the American College of Medical Genetics and Genomics (ACMG). A report of the recommendations, led by Robert C.

Philadelphia – By studying the underlying differences in gene expression during healing after a bone break in young versus aged mice, Jaimo Ahn, MD, PhD, assistant professor of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, and his colleagues aim to find specific pathways of fracture healing in humans. The team of researchers will present their findings in a poster presentation beginning Tuesday, March 19, 2013 at the 2013 American Academy of Orthopedic Surgeons annual meeting in Chicago.

WEST LAFAYETTE, Ind. - New research findings may help scientists design drugs to treat a virus infection that causes potentially fatal brain swelling and paralysis in children.

The virus, called enterovirus 71, causes hand, foot and mouth disease and is common throughout the world. Although that disease usually is not fatal, the virus has been reported to cause fatal encephalitis in infants and young children, primarily in the Asia-Pacific region.

Currently, no cure exists for the infection.

Researchers from the RIKEN Advanced Science Institute and Nippon Medical School in Japan have identified a protein likely to be involved in the exacerbation of chronic obstructive pulmonary disease (COPD). This protein, Siglec-14, could serve as a potential new target for the treatment of COPD exacerbation.

In a study published today in the journal Cellular and Molecular Life Sciences the researchers show that COPD patients who do not express Siglec-14, a glycan-recognition protein, are less susceptible to exacerbation compared with those who do.

A national survey of health professionals showed that drug shortages are taking a heavy toll on cancer patients, forcing treatment changes and delays that for some patients meant worse outcomes, more therapy-related complications and higher costs. St. Jude Children's Research Hospital investigators played an important role in the study.

AUGUSTA, Ga. – Food and environment can chemically alter your gene function and scientists have identified a gene that is consistently altered in obesity.

The gene LY86 was among a group of 100 genes identified as likely contributors to obesity through genome-wide association studies comparing the DNA of thousands of obese and lean individuals, said Dr. Shaoyong Su, genetic epidemiologist at the Medical College of Georgia at Georgia Regents University.

UT Dallas researchers are developing a new low-light imaging method that could improve a number of scientific applications, including the microscopic imaging of single molecules in cancer research.

Electrical engineering professor Dr. Raimund Ober and his team recently published their findings in the journal Nature Methods. In the journal, they describe a method which minimizes the deterioration of images that can occur with conventional imaging approaches.