Cold Spring Harbor, N.Y. – Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression. Human Argonaute-2 (hAgo2) is known as "slicer" for its unique ability among the 4 human Argonaute proteins to directly cut messenger RNA -- which carries the information coded in genomic DNA to make a protein -- and thus disable "messages" generated from genes.
Body
CHAPEL HILL, N.C. - While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects.
LA JOLLA, CA – June 6, 2013 – Humans have been raising cows for their meat, hides and milk for millennia. Now it appears that the cow immune system also has something to offer. A new study led by scientists from The Scripps Research Institute (TSRI) focusing on an extraordinary family of cow antibodies points to new ways to make human medicines.
In animals that reproduce by internal fertilization, as humans do, you'd think a penis would be an organ you couldn't really do without, evolutionarily speaking. Surprisingly, though, most birds do exactly that, and now researchers reporting in the Cell Press journal Current Biology on June 6 have figured out where, developmentally speaking, birds' penises have gone.
Studies showing how bird flu viruses could adapt to humans offer surveillance and vaccine strategies
Bird flu viruses are potentially highly lethal and pose a global threat, but relatively little is known about why certain strains spread more easily to humans than others. Two studies published by Cell Press June 6th in the journal Cell identify mutations that increase the infectivity of H5N1 and H7N9 viruses through improved binding to receptors in the human respiratory tract. The findings offer much-needed strategies for monitoring the emergence of dangerous bird flu strains capable of infecting humans and for developing more effective vaccines.
For some species, living twice as long in good health depends on no more than a few genes. When this fact was revealed by studies on worms three decades ago, it ushered in a golden age of ageing studies that has delivered numerous results, but also sown some confusion. The prestigious journal Cell is now publishing an exhaustive review of the subject that aims to set things straight and "serve as a framework for future studies." All the molecular indicators of ageing in mammals – the nine signatures that mark the advance of time – are set out in its pages.
NEW BRUNSWICK, N.J. – Rutgers scientists have described for the first time the biological process of how corals create their skeletons – destined to become limestones – which form massive and ecologically vital coral reefs in the world's oceans.
In a publication in Current Biology, Tali Mass and her colleagues at the Rutgers Institute of Marine and Coastal Sciences show that specific proteins produced by corals can form limestones in test tubes. These proteins, secreted by corals, precipitate carbonate that forms the corals' characteristic skeleton.
Cancer cells' appetite for sugar may have serious consequences for immune cell function, researchers at Washington University School of Medicine in St. Louis have learned.
The scientists found that when they kept sugar away from critical immune cells called T cells, the cells no longer produced interferon gamma, an inflammatory compound important for fighting tumors and some kinds of infection.
As tumors grow, their centers are squeezed of oxygen. And so tumors must flip specific genetic switches to survive in these hypoxic environments. A series of studies funded to do only basic science and published today in the journal Cell reports the serendipitous discovery of a druggable target necessary for the survival of tumors in these low-oxygen environments.
The genome is full of sequence repetitions. Sequence motif is added after sequence motif, sometimes more than a hundred times. Erratically it seems. And these sequence motifs bind proteins that control transcription factors in regions of the genome where no transcription should occur. A conundrum.
Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell today, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease.
Scientists at the Danish Stem Cell Center, DanStem, at the University of Copenhagen have discovered that they can make embryonic stem cells regress to a stage of development where they are able to make placenta cells as well as the other fetal cells. This significant discovery, published in the journal Cell Reports today, has the potential to shed new light on placenta related disorders that can lead to problematic pregnancies and miscarriages.
ROSEMONT, Ill.—Supplemental child restraints should be used by all children through age 8. When appropriate child safety restraint systems—based on a child's age and weight—are in use during motor vehicle crashes, the rates of mortality and serious injury significantly decrease. Most parents don't know that their older children—ages 4 to 8—should use additional measures to protect them from serious injury or death in case of a crash.
New Rochelle, NY, June 6, 2013— Immunocompromised mice, created by inactivating the genes that would allow them to recognize and attack donor cells or organs, are critical for studies of bone marrow reconstitution. A more rapid and reliable technique for identifying these mice in breeding colonies is described in an article in BioResearch Open Access.
Researchers from Germany have found that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication. Findings published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, suggest seasonal fluctuations in vitamin D and HBV levels point to a link in these variables among patients with chronic HBV.