Body

Nuclear receptors reveal possible interventions for cancer, obesity

Nuclear receptors reveal possible interventions for cancer, obesity

HOUSTON, Jan. 10, 2011 – Research with significant implications in the treatment and intervention of cancer and obesity has been published recently in two prestigious journals by University of Houston (UH) biochemist Dr. Jan-Åke Gustafsson.

GEN reports on biotech acquisition deals in 2010 that topped $1 billion

New Rochelle, NY, January 10, 2011—The mega-mergers of 2009 did not continue into 2010. While the three biggest acquisitions in 2009 each had a price tag of more than $40 billion, only last year's top purchase got above that mark, according to an evaluation of reported deals conducted by Genetic Engineering & Biotechnology News (GEN) (http://www.genengnews.com/). The only other mega takeover for the year, sanofi-aventis' move to buy Genzyme, is still being worked out.

'Hot-bunking' bacterium recycles iron to boost ocean metabolism

In the vast ocean where an essential nutrient—iron—is scarce, a marine bacterium that launches the ocean food web survives by using a remarkable biochemical trick: It recycles iron.

By day, it uses iron in enzymes for photosynthesis to make carbohydrates; then by night, it appears to reuse the same iron in different enzymes to produce organic nitrogen for proteins.

Men with macho faces attractive to fertile women, researchers find

When their romantic partners are not quintessentially masculine, women in their fertile phase are more likely to fantasize about masculine-looking men than are women paired with George Clooney types.

But women with masculine-looking partners do not necessarily become more attracted to their partners, a recent study co-authored by a University of Colorado at Boulder researcher concludes.

UNC researchers inch closer to unlocking potential of synthetic blood

A team of scientists has created particles that closely mirror some of the key properties of red blood cells, potentially helping pave the way for the development of synthetic blood.

The new discovery – outlined in a study appearing in the online Early Edition of the Proceedings of the National Academy of Sciences during the week of Jan. 10, 2011 – also could lead to more effective treatments for life threatening medical conditions such as cancer.

Hard-to-find fish reveals shared developmental toolbox of evolution

A SCUBA expedition in Australia and New Zealand to find the rare embryos of an unusual shark cousin enabled American and British researchers to confirm new developmental similarities between fish and mammals.

Study identifies new genetic signatures of breast cancer drug resistance

Study identifies new genetic signatures of breast cancer drug resistance

A new study conducted by Josh LaBaer's research team in the Biodesign Institute at Arizona State University has pinpointed more than 30 breast cancer gene targets ---including several novel genes---that are involved in drug resistance to a leading chemotherapy treatment.

New method takes snapshots of proteins as they fold

New method takes snapshots of proteins as they fold

People have only 20,000 to 30,000 genes (the number is hotly contested), but they use those genes to make more than 2 million proteins. It's the protein molecules that domost of the work in the human cell. After all, the word protein comes from the Greek prota, meaning "of primary importance."

Lake Erie hypoxic zone doesn't affect all fish the same, study finds

Lake Erie hypoxic zone doesn't affect all fish the same, study finds

WEST LAFAYETTE, Ind. - Large hypoxic zones low in oxygen long have been thought to have negative influences on aquatic life, but a Purdue University study shows that while these so-called dead zones have an adverse affect, not all species are impacted equally.

Being poor can suppress children's genetic potentials

AUSTIN, Texas — Growing up poor can suppress a child's genetic potential to excel cognitively even before the age of 2, according to research from psychologists at The University of Texas at Austin.

Half of the gains that wealthier children show on tests of mental ability between 10 months and 2 years of age can be attributed to their genes, the study finds. But children from poorer families, who already lag behind their peers by that age, show almost no improvements that are driven by their genetic makeup.

Embryonic stem cells help deliver 'good genes' in a model of inherited blood disorder

Researchers at Nationwide Children's Hospital report a gene therapy strategy that improves the condition of a mouse model of an inherited blood disorder, Beta Thalassemia. The gene correction involves using unfertilized eggs from afflicted mice to produce a batch of embryonic stem cell lines. Some of these stem cell lines do not inherit the disease gene and can thus be used for transplantation-based treatments of the same mice.

First strawberry genome sequence promises better berries

DURHAM, N.H. – An international team of researchers, including several from the University of New Hampshire, have completed the first DNA sequence of any strawberry plant, giving breeders much-needed tools to create tastier, healthier strawberries. Tom Davis, professor of biological sciences at UNH, and postdoctoral researcher Bo Liu were significant contributors to the genome sequence of the woodland strawberry, which was published last month in the journal Nature Genetics.

An earlier start on diagnosing breast, prostate cancers

An earlier start on diagnosing breast, prostate cancers

Using biological samples taken from patients and state-of-the-art biochemical techniques, a Florida State University researcher is working to identify a variety of "biomarkers" that might provide earlier warnings of the presence of breast and prostate cancers.

Protein thought to protect against oxidative stress also promotes clogging of arteries

UCLA researchers have found that a protein that plays an important role in some antioxidant therapies may not be as effective due to additional mechanisms that cause it to promote atherosclerosis, or clogging of the arteries.

Published in the January issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology, the finding may give clues as to why some antioxidant therapies have not yielded more positive results.

New hope in fight against Huntington's disease

New hope in fight against Huntington's disease

Hope for new ways of treating devastating neurodegenerative disorders such as Huntington's disease has been raised by a trans-Atlantic team of researchers thanks to the use of cutting-edge genetic techniques.