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Immunotherapies that fight cancer have been a life-saving advancement for many patients, but the approach only works on a few types of malignancies, leaving few treatment options for most cancer patients with solid tumors. Now, in two related papers published April 28, 2021 in Science Translational Medicine, researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.

The discovery of ancient kumara pits just north of Dunedin dating back to the 15th century have shone a light on how scientific evidence can complement mātauranga Maori around how and where the taonga were stored hundreds of years ago.

Primary care practitioners often over-estimate the likelihood of a patient having a medical condition based on reported symptoms and laboratory test results. Such overestimations can lead to overdiagnosis and overtreatment, according to a recent study conducted by researchers at the University of Maryland School of Medicine (UMSOM) published in JAMA Internal Medicine.

Individuals who self-identify as Republicans became more skeptical of a potential COVID-19 vaccine and other inoculations, such as the flu shot, over the course of the pandemic, reveals a new study by the University of California San Diego.

Scientists at Tokyo Institute of Technology developed a new strategy for producing a wide range of organotin compounds, which are the building blocks of many organic synthesis methods. Their approach is based on the photoexcitation of stannyl anions, which alters their electronic state and increases their selectivity and reactivity to form useful compounds. This protocol will be helpful for the efficient synthesis of many bioactive products, novel drugs, and functional materials.

Though more than 131 million Americans have received at least one dose of COVID-19 vaccine to date, public confusion and uncertainty about the importance of second doses and continued public health precautions threaten to delay a U.S. return to normalcy, according to Cornell-led research published April 28 in the New England Journal of Medicine.

A new algorithm that taps data from a patient's electronic medical record can diagnose and stage chronic kidney disease, which is often undetected until it has caused irreversible damage.

The ability to turn on and off a physical process with just one photon is a fundamental building block for quantum photonic technologies. Realizing this in a chip-scale architecture is important for scalability, which amplifies a breakthrough by CCNY researchers led by physicist Vinod Menon. They've demonstrated for the first time the use of "Rydberg states" in solid state materials (previously shown in cold atom gases) to enhance nonlinear optical interactions to unprecedented levels in solid state systems.

A new paper written by Concordia researchers published in the Nature journal Scientific Reports used eye-tracking technology to record eye movements of readers and concluded that people with dyslexia have a profoundly different and much more difficult way of sampling visual information than normal readers.

Researchers at the University of Bonn and the research center caesar have succeeded in ultra-fast freezing proteins after a precisely defined period of time. They were able to follow structural changes on the microsecond time scale and with sub-nanometer precision. Owing to its high spatial and temporal resolution, the method allows tracking rapid structural changes in enzymes and nucleic acids. The results are published in the Journal of the American Chemical Society.

In an effort to fight the millions of tons of marine litter floating in the ocean, Florida State University researchers have developed a new virtual tool to track this debris. Their work, which was published in Frontiers in Marine Science, will help provide answers to help monitor and deal with the problem of marine litter.

A University of California San Diego engineering professor has solved one of the biggest mysteries in geophysics: What causes deep-focus earthquakes? These mysterious earthquakes originate between 400 and 700 kilometers below the surface of the Earth and have been recorded with magnitudes up to 8.3 on the Richter scale.

UArizona veterinary medicine associate professor Ryane Englar says that improving human interactions can also improve animal care.

UC Davis Comprehensive Cancer Center researchers found that targeting androgen receptors - a type of protein that is crucial for the function of testosterone - may destroy cancer cells. Focusing on this protein variant common in malignant bladder tumor cells may serve as a new avenue for treating bladder cancer in men.

The Southern Ocean dominates the oceanic uptake of human-made CO2. But how much carbon dioxide can it actually absorb in the future? This long-standing question remained unresolved as projections of different generation of climate models repeatedly showed a wide range of future Southern Ocean CO2 sink estimates. Climate scientists from Bern have now been able to reduce this large uncertainty by about 50 percent.

The results of a large, national heart attack study show that patients with a deadly complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Hospital in collaboration with four metro Detroit hospitals.

In a long-standing research project, an international research team led by the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) has used lasers to excise and analyse the finest tissue parts involved in barley spikelet organ formation. The results are of immense importance for further comparative studies among other grass or cereal crops and have recently been published in the journal Science Advances.

The subseafloor constitutes one of the largest and most understudied ecosystems on Earth. An interdisciplinary research team, led from ASU and the Woods Hole Oceanographic Institution (WHOI), sought to learn more about this ecosystem by studying North Pond on the western flank of the mid-Atlantic Ridge, a plate boundary located along the floor of the Atlantic Ocean. They found microbes that were active and poised to eat.

New research shows that the variety of online players is shrinking rapidly, although the overall size of the worldwide web continues to expand and functional and geographic opportunities are rising.

Two teams have created a new generation of highly specific CAR T cells, which safely cleared solid tumors in mice with mesothelioma, ovarian cancer, and the deadly brain cancer glioblastoma while outlasting and outperforming conventional CAR T cell designs.