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Synergistic effects of acoustics-based therapy and immunotherapy in cancer treatment
Announcing a new article publication for BIO Integration journal. In this review the authors Yuheng Bao, Jifan Chen, Pintong Huang and Weijun Tong from Zhejiang University, Hangzhou, China discuss the synergistic effects of acoustics-based therapy and immunotherapy in cancer treatment.
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Dartmouth-led study finds overemphasis on toy giveaways in TV ads unfairly promotes fast-food to children
A new Dartmouth-led study, published this week in the journal Pediatrics, has found that the disproportionate use of premiums within child-targeted TV advertising for children's fast-food meals is deceptive, violating the industry's own self-regulatory guidelines.
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SARS-CoV-2 research: Second possible effective mechanism of remdesivir discovered
After infection, SARS-CoV-2 causes the host cell to produce new virus particles and suppresses host cell defence mechanisms. Virus protein nsP3 plays a central role in the latter process. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the remdesivir binds to nsP3. This previously unknown effective mechanism may be important for the development of new drugs to combat RNA viruses.
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Friendly pelicans breed better
Captive pelicans that are free to choose their own friendships are more likely to breed successfully on repeated occasions, new research suggests.
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Agents that target viral RNA could be the basis for next generation anti-viral drugs
A new approach to tackling viruses by targeting the 'control centre' in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.
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Microneedle patch delivers antibiotics locally in the skin
MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers at Karolinska Institutet in Sweden are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results published in Advanced Materials Technologies show that the microneedle patch effectively reduces MRSA bacteria in the skin.
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Light meets superconducting circuits
EPFL researchers have developed a light-based approach to read out superconducting circuits, overcoming the scaling-up limitations of quantum computing systems.
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Cancer cells hijack the 3D structure of DNA
Scientists at EPFL and UNIL have used a novel algorithmic approach on cancer cells to understand how changes in histone marks (H3K27ac) induce repositioning of chromatin regions in the cell nucleus, and described how modifications of local contacts between regulatory elements (enhancers and promoters) influence oncogene expression.
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Study finds pretty plants hog research and conservation limelight
New Curtin University research has found a bias among scientists toward colourful and visually striking plants, means they are more likely to be chosen for scientific study and benefit from subsequent conservation efforts, regardless of their ecological importance.
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Do purines influence cancer development?
Numerous disease development processes are linked to epigenetic modulation. One protein involved in the process of modulation and identified as an important cancer marker is BRD4. A recent study by researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, now shows that the supply of purines as well as the purine synthesis of a cell can influence BRD4 activity and thus play a role in the carcinogenesis process. The findings were published in Nature Metabolism.
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Tweet and re-tweet: songbird stuttering allows researchers to pinpoint causes in the brain
Biologists have identified specific neural firing patterns that can induce stuttering and stammering in songbirds. The discovery offers a model system that could enable researchers to uncover the origins of speech dysfunction in humans, and possible treatment to restore normal speech.
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In the emptiness of space, Voyager I detects plasma 'hum'
NASA's Voyager I spacecraft has long since zipped past the edge of the solar system through the heliopause - the solar system's border with interstellar space - into the interstellar medium. Now, its instruments have detected the constant drone of interstellar gas (plasma waves), according to Cornell University-led research published in Nature Astronomy.
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How planets form controls elements essential for life
How a planet comes together has implications for whether it captures and retains the volatile elements, including nitrogen, carbon and water, that eventually give rise to life, according to scientists at Rice University.
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Study led by Penn Medicine reveals new mechanism of lung tissue regeneration
New research performed in mice models at Penn Medicine shows, mechanistically, how the infant lung regenerates cells after injury differently than the adult lung, with alveolar type 1 (AT1) cells reprograming into alveolar type 2 (AT2) cells (two very different lung alveolar epithelial cells), promoting cell regeneration, rather than AT2 cells differentiating into AT1 cells, which is the most widely accepted mechanism in the adult lung.
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New tools enable rapid analysis of coronavirus sequences and tracking of variants
Widespread sequencing of SARS-CoV-2 genomes presents new opportunities for tracing global and local transmission dynamics, but analyzing so much genomic data is challenging. The sheer number of coronavirus genome sequences and their rapid accumulation makes it hard to place new sequences on a "family tree" showing how they are all related. But researchers at the UC Santa Cruz Genomics Institute have developed a new method that does this with unprecedented speed.
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Diagramming the brain with colorful connections
BARseq2 is a new brain mapping technique that can identify cells by the unique sets of genes they use. Neuroscientists can use this tool to understand how brain cells are organized and connected.
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Implanted wireless device triggers mice to form instant bond
For the first time ever, researchers have wirelessly programmed -- and then deprogrammed -- mice to socially interact with one another in real time. The advancement is thanks to a first-of-its-kind ultraminiature, wireless, battery-free and fully implantable device that uses light to activate neurons.
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Bronze Age migrations changed societal organization and genomic landscape in Italy
A new study from the Institute of Genomics of the University of Tartu, Estonia has shed light on the genetic prehistory of populations in modern day Italy through the analysis of ancient human individuals around 4,000 years ago. The genomic analysis of ancient samples enabled researchers from Estonia, Italy, and the UK to date the arrival of the Steppe-related ancestry component to 3,600 years ago in Central Italy, also finding changes in burial practice and kinship structure during this transition.
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Scientists find mechanism that eliminates senescent cells
Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct -- or senescent -- cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.
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Long-lasting medications may improve treatment satisfaction for opioid use disorder
A commentary from leaders at the National Institute on Drug Abuse discusses a new study showing that an extended-release injection of buprenorphine, a medication used to treat opioid use disorder, was preferred by patients compared to immediate-release buprenorphine, which must be taken orally every day. Extended-release formulations of medications used to treat opioid use disorder may be a valuable tool to address the current opioid addiction crisis and reduce its associated mortality.
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