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Therapeutics that can shut down harmful genes need a reliable delivery system
So far, only a handful of siRNA, or other RNA interference-based therapeutics that can shut down harmful genes to keep viruses from spreading have been approved. Chemical engineering researchers in the Cockrell School of Engineering have created several nanoparticles to help solve the problem of getting the siRNA into the body and guiding it to the target.
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Study reveals new options to help firms improve the food recall process
New research from the University of Notre Dame helps to close the gap between what is and isn't known about food recalls.
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Scientists shed light on the mechanism of photoactivation of the orange carotenoid protein
It is a photoreceptor of cyanobacteria which protects them from excessive exposure to light. The design and production of a mutant variant of OCP and exploitation of state-of-the-art spectroscopic approaches made it possible to describe a photochemcial reaction that is new for carotenoids. These results will open up prospects for the development of new light-controlled systems and biomaterials.
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Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer
A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription.
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Domestic abuse head injuries prevalent among women in prison, study finds
An international study has found that four out of five women in prison in Scotland have a history of head injury, mostly sustained through domestic violence. Published recently in The Lancet, researchers, including SFU psychology graduate student Hira Aslam, say the study has important implications for the female prison population more broadly and could help to inform mental health and criminal justice policy development.
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Diamonds engage both optical microscopy and MRI for better imaging
Microdiamonds with nitrogen vacancy centers are increasingly used as biological tracers thanks to the optical fluorescence of NV centers. But the NV centers also can be spin-polarized by low-power lasers, and the polarized centers then polarize nearby carbon-13 atoms occurring naturally in the diamonds. These hyperpolarized C-13 atoms can be detected by NMR imaging. UC Berkeley chemists now demonstrate dual-mode imaging with NV-center diamonds, potentially allowing high-quality imaging 10 times deeper than with optics alone.
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New technology makes tumor eliminate itself
A new technology developed by UZH researchers enables the body to produce therapeutic agents on demand at the exact location where they are needed. The innovation could reduce the side effects of cancer therapy and may hold the solution to better delivery of Covid-related therapies directly to the lungs.
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Parts of Greenland may be on the verge of tipping: New early-warning signals detected
Scientists have detected new early-warning signals indicating that the central-western part of the Greenland Ice Sheet may undergo a critical transition relatively soon. Because of rising temperatures, a new study by researchers from Germany and Norway shows, the destabilization of the ice sheet has begun and the process of melting may escalate already at limited warming levels. A tipping of the ice sheet would substantially increase long-term global sea level rise.
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A path to aggressive breast cancer
Following the progression of breast cancer in an animal model revealed a path that transforms a slow-growing cancer type known as estrogen receptor (ER)+/HER2+ into a fast-growing ER-/HER2+ type that aggressively spreads or metastasizes to other organs.
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African rainforests still slowed climate change despite record heat and drought
Intact rainforests across tropical Africa continued to remove carbon from the atmosphere before and during the 2015-2016 El Niño, despite the extreme heat and drought. Theyl removed 1.1 billion tonnes of carbon dioxide per year from the atmosphere during the El Niño monitoring period. This rate is equivalent to three times the carbon dioxide emissions of the UK in 2019. Scientists were surprised by this discovery.
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From Avocet to Zebra Finch: big data study finds more than 50 billion birds in the world
There are roughly 50 billion individual birds in the world, a new big data study by UNSW Sydney suggests - about six birds for every human on the planet.
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Slow research to understand fast change
A new open-access research collection published in Ecosphere reveals unexpected lessons drawn from decades of rich data from the Long Term Ecological Research (LTER) Network.
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Alcohol problems severely undertreated
Researchers at Washington University School of Medicine in St. Louis have found that although the vast majority of people with alcohol use disorder see their doctors regularly for a range of issues, fewer than one in 10 ever get treatment to help curb their drinking.
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Civil commitment for substance use disorder treatment -- what do addiction medicine specialists think?
Amid the rising toll of opioid overdoses and deaths in the U.S., several states are considering laws enabling civil commitment for involuntary treatment of patients with substance use disorders (SUDs). Most addiction medicine physicians support civil commitment for SUD treatment - but others strongly oppose this approach, reports a survey study in Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM).
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Ethnicity, geography and socioeconomic factors determine likelihood of detecting serious congenital
Mothers who are Hispanic or who come from rural or low socioeconomic status neighborhoods are less likely to have their child's critical heart condition diagnosed before birth, according to a new study in the journal Circulation.
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Bird data from Ethiopia fills in baseline data gaps
The study establishes baseline observations for tropical birds in East Africa, filling in an important data gap for monitoring biodiversity and tropical ecosystem health in a warming world.
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Insulin is necessary for repairing olfactory neurons
Insulin plays a critical role in the maturation, after injury, of immature olfactory sensory neurons. Applying insulin into the nasal passage could be developed as a therapy for injury caused by a host of issues.
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Lives may be saved by implementing ATS-recommended air quality standards
Air quality standards recommended by the American Thoracic Society (ATS) have the potential to prevent more illness and death than standards adopted by the U.S. Environmental Protection Agency (EPA), according to research presented at the ATS 2021 International Conference.
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Researchers reveal new tool to help prevent suicide
A team of Welsh academics has developed a new method of supporting health professionals to make clinical decisions about people who may be at risk of taking their own lives.
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Multi-gene testing could detect more hereditary cancer syndromes
Up to 38.6% of people with colon cancer who have a hereditary cancer syndrome--including 6.3% of those with Lynch syndrome--could have their conditions remain undetected with current universal tumor-screening methods, and at least 7.1% of people with colorectal cancer have an identifiable inherited genetic mutation, according to new data published by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
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