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Oncotarget: Retaining nanomolar potency in lung cancer with therapy-refractory mutations
The gene correlates of LP-184 sensitivity allow additional personalization of therapeutic options for future treatment of NSCLC.
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Oncotarget: Urine protein biomarkers of bladder cancer
These Oncotarget findings suggest that urine IL-1α, IL-1ra and IL-8 are useful indicators of bladder cancer.
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Cancer treatments may accelerate cellular aging
New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue. The findings are published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society.
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No cause for alarm about graduate students' mental health
Talk of a graduate student mental health crisis is abundant in academic and popular media, but a University of Otago study has found no evidence of one in New Zealand.
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Researchers develop novel raman method to capture target molecules in small gaps actively
SERS is a spectroscopic technique typically used to determine vibrational modes of molecules. It's commonly used in chemistry to provide a structural fingerprint by which molecules can be identified.
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Identifying how chemotherapy drug works could deliver personalized cancer treatment
Researchers have identified the genetic and molecular mechanisms within cells that make the chemotherapy drug decitabine--used to treat patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) --work for some patients but not others. The findings should assist clinicians in developing more patient-specific treatment strategies.
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New immune players involved in metabolic liver disease
In a recent study reported in Nature Medicine, Prof. Ido Amit and team members have discovered that a subtype of immune cells, called dendritic cells, becomes activated in the liver in NASH patients and in animal models, and promotes the progression of this condition. This finding may in the future help develop new treatments for NASH.
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Is closing the gap working?
Gaping policy shortfalls in the Australian Government's 'Closing the Gap' program have seen it fail to reduce disparities in Indigenous health, income, employment, child removal and incarceration, Flinders University researchers say. Their five-year study examined why the targets of Australia's national Closing the Gap strategy to reduce or eliminate inequalities in health, education and employment outcomes between Aboriginal and Torres Strait Islander people and other Australians have mostly not been met.
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Myopia link to poor sleep, and screen time
New research from Australia indicates people with myopia are more likely to experience poorer sleep quality than people with normal vision.The study indicates that people with short-sightedness have more delayed circadian rhythms and lower production of melatonin, a hormone secreted in the brain and responsible for regulating sleep at night, compared to people with normal vision.
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A natural food supplement may relieve anxiety
A natural food supplement reduces anxiety in mice, according to a new Weizmann Institute of Science study. The plant-derived substance, beta-sitosterol, was found to produce this effect both on its own and in synergic combination with an antidepressant known under the brand name Prozac.
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COVID-19 vaccine benefits still outweigh risks, despite possible rare heart complications
Late last week, the U.S. Centers for Disease Control and Prevention (CDC) alerted health care professionals that they are monitoring the Vaccine Adverse Events Reporting System (VAERS) and the Vaccine Safety Datalink (VSD) for cases of young adults developing the rare heart-related complication myocarditis, after receiving a COVID-19 vaccine manufactured by Pfizer-BioNTech or Moderna.
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Early research suggests climate change could lead to more stillbirths
Scientists are investigating whether rising global temperatures may lead to more stillbirths, saying further study is needed on the subject as climates change.
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Otago study helps explain how religious beliefs are formed
Feeling anxious can direct our attention and memory toward supernatural beings such as gods, a University of Otago study has found.
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New study targets secrets of great entrepreneurial cities
New study by Australian and US researchers describe how an "open-minded" population empowers city life.
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No link between milk and increased cholesterol according to new study of 2 million people
Regular consumption of milk is not associated with increased levels of cholesterol, according to new research of nearly 2 million people.
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New research suggests that night shift work is linked to menstrual irregularity and increased of developing endometriosis
According to a study being presented at the 23rd European Congress of Endocrinology (e-ECE 2021), on Sunday 23 May at 19:00 CET (www.ece2021.org), women working night shifts may be at a greater risk of menstrual irregularity and developing endometriosis.
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IBS patients' symptoms improved under COVID-19 lockdown orders
Patients' irritable bowel syndrome (IBS) symptoms unexpectedly improved when they were under COVID-19 stay-at-home orders, reaffirming the gut-brain connection in functional gastrointestinal disorders, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021.
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Finer touch for tuning stem cell "fate" with substrates of varying stiffness
Researchers from Tokyo Metropolitan University have been quantifying how different batches of mesenchymal stem cells respond to the mechanical stiffness of their environments. They focused on how certain proteins were "localized" in cell nuclei and found key trends in how this changed with stiffness. Their findings explain inconsistencies between previous findings and may guide how scientists control the state of stem cells for research and medical treatments.
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Smart toilet may soon analyze stool for health problems
An artificial intelligence tool under development at Duke University can be added to the standard toilet to help analyze patients' stool and give gastroenterologists the information they need to provide appropriate treatment, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. The new technology could assist in managing chronic gastrointestinal issues such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
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Vast under-treatment of diabetes seen in global study
Nearly half a billion people have diabetes, but most aren't getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data from people with the condition. Many don't even know they have the condition.Only 1 in 10 people with diabetes in the 55 low- and middle-income countries studied receive the type of comprehensive care that's been proven to reduce diabetes-related problems.
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