Tech
In 2015, 170 countries worldwide adopted the Paris Agreement, with the goal limiting the average global temperature increase to 1.5°C. Following the agreement, many countries and cities proposed targets for greenhouse gas mitigation. However, the UNEP Emissions Gap Report 2020 shows that, without drastic and strict actions to mitigate the climate crisis, we are still heading for a temperature increase of more than 3°C by the end of the 21st century.
Oncotarget published "Inhibitory effects of Tomivosertib in acute myeloid leukemia" which reported that the authors evaluated the therapeutic potential of the highly-selective MNK1/2 inhibitor Tomivosertib on AML cells.
Sclerosis, Parkinson's Disease, Alzheimer's and epilepsy are but a few of the central nervous system disorders. They are also very difficult to treat, since the brain is protected by the blood-brain barrier.
The blood-brain barrier works as a border wall between the blood and the brain, allowing just certain molecules to enter the brain. And whereas water and oxygen can get through, as can other substances such as alcohol and coffee. But it does block more than 99 percent of potentially neuroprotective compounds from reaching their targets in the brain.
Tsukuba, Japan - A scientist from the Division of Quantum Condensed Matter Physics at the University of Tsukuba has formulated a new theory of superconductivity. Based on the calculation of the "Berry connection," this model helps explain new experimental results better than the current theory. The work may allow future electrical grids to send energy without losses.
Researchers from Tokyo Medical and Dental University (TMDU) identify pathways that link a high-fat diet to atherosclerosis in mice
Tokyo, Japan - It's long been known that a high-fat diet can lead to clogged arteries, but we have only recently begun to learn in detail how the process works. A new study in experimental mice could go a long way to finding treatments to keep arteries open and flowing.
The shale boom (mining of shale oil and gas) has contributed to an increase of crime rates in US states where 50-60% of the population lives in rural areas. That is West Virginia, North Dakota, and Arkansas. Especially the number of violent crimes has increased. This is the conclusion reached by economists from Ural Federal University (UrFU, Russia) and Shippensburg University of Pennsylvania (USA). The research results are published in The Extractive Industries and Society.
In spite of many clinical options, people with mental health problems including eating disorders often do not access professional help within the crucial first 12 months - in part because of lack of information in the community about accessing targeted services.
Anxiety and depression are normal reactions to situations such as pandemic lockdowns but arming yourself with some useful strategies can alleviate this, says Flinders University Distinguished Professor of Psychology Tracey
Wade.
Tsukuba, Japan - Extended exposure to light during nighttime can have negative consequences for human health. But now, researchers from Japan have identified a new type of light with reduced consequences for physiological changes during sleep.
In a study published in June 2021 in Scientific Reports, researchers from University of Tsukuba compared the effects of light-emitting diodes (LEDs), which have been widely adopted for their energy-saving properties, with organic light-emitting diodes (OLEDs) on physical processes that occur during sleep.
Tsukuba, Japan - Scientists from the Division of Physics at the University of Tsukuba used the quantum effect called "spin-locking" to significantly enhance the resolution when performing radio-frequency imaging of nitrogen-vacancy defects in diamond. This work may lead to faster and more accurate material analysis, as well as a path towards practical quantum computers.
The discovery of the first high-temperature superconductor in 1986 brought with it the hope that superconductivity would one day revolutionise power transmission, electronic devices and other technologies. Materials that show superconductivity (zero electrical resistance) generally do so at an extremely low temperature. For their use to become widespread and world-changing, we need to develop a material that is superconducting close to room temperature.
Babies younger than four weeks old, called neonates, were once thought not to perceive pain due to not-yet-fully-developed sensory systems, but modern research says otherwise, according to researchers from Hiroshima University in Japan.
Two factors that play a key role in climate change - increased climate warming and elevated ozone levels - appear to have detrimental effects on soybean plant roots, their relationship with symbiotic microorganisms in the soil and the ways the plants sequester carbon.
The results, published in the July 9 edition of Science Advances, show few changes to the plant shoots aboveground but some distressing results underground, including an increased inability to hold carbon that instead gets released into the atmosphere as a greenhouse gas.
How does unicellular life transition to multicellular life? The research team of Professor Lutz Becks at the Limnological Institute of the University of Konstanz has taken a major step forward in explaining this very complex process. They were able to demonstrate - in collaboration with a colleague from the Alfred Wegner Institute (AWI) - that the unicellular green algae Chlamydomonas reinhardtii, over only 500 generations, develops mutations that provide the first step towards multicellular life.
Pichia pastoris (syn. Komagataella phaffii), a model methylotrophic yeast, can easily achieve high density fermentation, and thus is considered as a promising chassis cell for efficient methanol biotransformation. However, inefficient gene editing and lack of synthetic biology tools hinder its metabolic engineering toward industrial application.
Recently, a research group led by Prof. ZHOU Yongjin from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences established an efficient genetic engineering platform in Pichia pastoris.