Tech
peer review/experimental study/animals/cells
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease.
Children treated for cancer with approaches such as chemotherapy can develop therapy-related myeloid neoplasms (a second type of cancer) with a dismal prognosis. Scientists at St. Jude Children's Research Hospital have characterized the genomic abnormalities of 84 such myeloid neoplasms, with potential implications for early interventions to stop the disease. A paper detailing the work was published today in Nature Communications.
An international research team led by Professor Kari Rissanen of the University of Jyvaskyla (Finland) and Professor Antonio Frontera of the University of Balearic Islands (Spain) has demonstrated that positively charged iodine (termed iodonium) is able to favorably interact with a silver cation (Ag+), overcoming the strong electrostatic repulsion. The research was published online in Chem -journal 8th of February 2021.
In a courtesy call to HE the President of Malta at San Anton Palace on Thursday, February 11, 2021, Dr Noel Aquilina from the Department of Chemistry, accompanied by Professor Emmanuel Sinagra, Head of the Department of Chemistry and Dean of the Faculty of Science at the University of Malta, presented the findings of a landmark study. This study shows and confirms that airborne particulate matter (PM), apart from several toxic components, is also contaminated with tobacco smoke-driven particulates.
"We are surrounded by a huge number of systems - biological, technical, economic, which we can influence, which we can control. The task is to do it optimally, for example, reaching the desired point with a minimum of effort, resources, and time, - explains Prof. Yurii Averboukh. - From a mathematical point of view, the task is narrowed down to the theory of optimal control.
Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition.
Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison's disease, a condition where the body's immune systems destroys the adrenal cortex leading to a life-threatening hormonal deficiency of cortisol and aldosterone.
Groundbreaking study
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs).
New research shows that hurricane maximum wind speeds in the subtropical Atlantic around Bermuda have more than doubled on average over the last 60 years due to rising ocean temperatures in the region.
Hurricanes intensify by extracting energy from the warm ocean surface via air-sea heat fluxes, so a warmer ocean can lead to more intense hurricanes.
Improving predictions of wind speeds from hurricanes will help determine the right level of response in advance of the storm and potentially limit the resulting damage in Bermuda.
In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein. However, it is not well known how these proteins interact with the Huntington's disease protein. New research by Patrick van der Wel (University of Groningen, the Netherlands) and colleagues at the University of Texas has partially resolved the structure of heat shock proteins that bind to such aggregating proteins, helping us to understand how they work.
Scientists have accepted natural selection as a driver of evolution for more than 160 years, thanks to Charles Darwin.
But University of Cincinnati biologist Michal Polak says Darwin's book "The Descent of Man" only tells part of the story. Sometimes when the victor vanquishes his sexual rival, the quest to pass genes to the next generation is just beginning.
Fast and energy-efficient future data processing technologies are on the horizon after an international team of scientists successfully manipulated magnets at the atomic level.
Physicist Dr Rostislav Mikhaylovskiy from Lancaster University said: "With stalling efficiency trends of current technology, new scientific approaches are especially valuable. Our discovery of the atomically-driven ultrafast control of magnetism opens broad avenues for fast and energy-efficient future data processing technologies essential to keep up with our data hunger."
WORCESTER, Mass. -- New research by Christopher A. Williams, an environmental scientist and professor in Clark University's Graduate School of Geography, reveals that deforestation in the U.S. does not always cause planetary warming, as is commonly assumed; instead, in some places, it actually cools the planet.
UPTON, NY--Scientists at the U.S. Department of Energy's Brookhaven National Laboratory, Stony Brook University (SBU), and other collaborating institutions have uncovered dynamic, atomic-level details of how an important platinum-based catalyst works in the water gas shift reaction. This reaction transforms carbon monoxide (CO) and water (H2O) into carbon dioxide (CO2) and hydrogen gas (H2)--an important step in producing and purifying hydrogen for multiple applications, including use as a clean fuel in fuel-cell vehicles, and in the production of hydrocarbons.
In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.
Now, experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance.
Seismic monitoring devices linked to the internet are vulnerable to cyberattacks that could disrupt data collection and processing, say researchers who have probed the devices for weak points.
Common security issues such as non-encrypted data, insecure protocols, and poor user authentication mechanisms are among the biggest culprits that leave seismological networks open to security breaches, Michael Samios of the National Observatory of Athens and colleagues write in a new study published in Seismological Research Letters.