The global burden of sickle cell anemia (SCA), a hereditary blood disorder, is increasing, with almost half a million babies estimated to be born with the condition in 2050, according to a study published in this week's PLOS Medicine. The study, conducted by Frédéric Piel and colleagues from the University of Oxford and Imperial College in the United Kingdom, and the KEMRI/Wellcome Trust Research Programme, Kenya, suggests that implementing basic health interventions could significantly reduce death rates in children aged less than 5 years with the condition.