Many recently developed pneumococcal serotyping methods detect the dominant serotype in a laboratory or field sample, but several fail to detect minor serotypes, according to a study published this week in PLOS Medicine. This investigation of 20 current methods, conducted by Catherine Satzke of the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia, and colleagues, indicates that a microarray analysis with culture amplification is a top-performing method, but a cheaper culture and latex sweep method represents a viable alternative.