The San Andreas Fault system, which runs almost the entire length of California, is prone to shaking, causing about 10,000 minor earthquakes each year just in the southern California area.
However, cities that line the fault, like Los Angeles and San Francisco, have not experienced a major destructive earthquake -- of magnitude 7.5 or more -- since their intensive urbanizations in the early twentieth century. With knowledge that large earthquakes occur at about 150-year intervals on the San Andreas, seismologists are certain that the next 'big one' is near.