Culture

Finding quasars: Rare extragalactic objects are now easier to spot

Astrophysicists from the University of Bath have developed a new method for pinpointing the whereabouts of extremely rare extragalactic objects. They hope their technique for finding 'changing-look quasars' will take scientists one step closer to unravelling one of greatest mysteries of the universe - how supermassive black holes grow. Quasars are believed to be responsible for regulating the growth of supermassive black holes and their host galaxies.

A quasar is a region of spectacular luminosity at the centre of a galaxy, powered by a supermassive black hole - the largest type of black hole, with a mass that exceeds that of our sun by millions or billions. There is a supermassive black hole at the centre of the Milky Way.

Changing-look quasars switch rapidly between a state of high luminosity and one of low luminosity, and scientists are yet to work out why. When the brightness is dialed down, a quasar is too faint to be seen against the backdrop of the host galaxy, making it hard for space scientists to find either it or the supermassive black hole it is connected to.

The new detection method will enable researchers to find quasars undergoing extreme changes in luminosity, and therefore to create a more comprehensive census of supermassive blackholes. The next step will be to study the causes of the luminosity switches, to give scientists a better understanding of how supermassive black holes grow. From this, clues are likely to emerge about the chain of events that give rise to the growth of galaxies, as the energy output from supermassive black holes can affect the fate of galaxies.

Astrophysicist Dr Carolin Villforth, who was involved in the research, said: "These quasars and supermassive blackholes are extremely important for galaxy evolution - the more we learn about them, the more we understand how they influence the growth of galaxies."

WHAT EXACTLY ARE QUASARS?

Quasars are the most luminous persistent source of light in the universe. Many galaxies, including our own, are thought to have one, and astrophysicists have identified more than a million in total.

Quasars are formed when gaseous matter is drawn by gravitations forces towards a supermassive black hole. As this gas approaches the black hole, it forms an 'accretion disk' which orbits the black hole. Energy is released from the disk in the form of electromagnetic radiation, and it is this radiation that produces the quasar's luminosity.

The accretion disk is surrounded by a thick, dusty donut that obscures much of the quasar's emission. Because the dusty structure is very large, the level of obscuration should not change on human timescales, however a changing-look quasar can appear to switch from bright to dark quickly (within a human year), which would be highly surprising if true. Creating a more comprehensive list of changing-look quasars would be a major step towards understanding the reasons behind these apparent transitions.

Previous efforts to identify changing-look quasars have relied on variability in a wide range of wavelengths - a technique called photometric variability, which is known to miss lower luminosity quasars. The Bath researchers used spectroscopic data to assess the changes in very small wavelength ranges, allowing them to detect changing-look quasars that had been missed by photometric searches. Using this technique, they spotted four changing-look quasars millions of lightyears from earth. All four were too dim to be picked up by photometric searches. Earlier identification efforts had only found two of these quasars in the same area.

Former MPhys student at Bath, Bart Potts, who led the research, explained: "We took a previous dataset and applied our new method to see if we could identify any new changing quasars that others had missed. This gave us a bigger set of changing-look quasars for further study, and validated that our methodology was more sensitive than others, which was great. It shows that our methodology is more sensitive to weaker luminosity."

He added: "Ultimately, this finding will give something to the academic community that studies quasars. It will help others further their research into why this specific type of quasar goes through luminosity switches. We are helping our community find important answers to big questions."

Credit: 
University of Bath

Exercise likely to be best treatment for depression in coronary heart disease

image: Dr Frank Doyle, Senior Lecturer Division of Population Health Sciences, RCSI University of Medicine and Health Sciences

Image: 
RCSI University of Medicine and Health Sciences

Tuesday, 8 June 2021: A study by RCSI indicates that exercise is probably the most effective short-term treatment for depression in people with coronary heart disease, when compared to antidepressants and psychotherapy or more complex care.

The study, led by researchers at RCSI University of Medicine and Health Sciences, is published in the June edition of Psychosomatic Medicine.

This is the first systematic review to compare treatments for depression in those with coronary disease and the findings provides valuable clinical information to help doctors determine the best treatment plan for patients.

The researchers reviewed treatment trials which investigated antidepressants, psychotherapy, exercise, combined psychotherapy and antidepressants, and collaborative care (i.e. treatments devised by a multidisciplinary team of clinicians with input from the patient).

To measure effectiveness, the researchers looked at factors including patient adherence to the treatment (dropout rate) and change in depressive symptoms eight weeks after commencing treatment.

The strongest treatment effects were found to be exercise and combination treatments (antidepressants and psychotherapy). However, as the combination study results have a high risk of bias, the findings of the review suggest that exercise is probably the most effective treatment. Antidepressants had the most research support, while psychotherapy and collaborative care did not perform very well.

"Depression is common in patients with coronary artery disease. Having both conditions can have a significant impact on the quality of life for patients so it is vital that they access to the most effective treatments," commented Dr Frank Doyle, Senior Lecturer Division of Population Health Sciences, RCSI and the study's first author.

"Our study indicates that exercise is likely to be the best treatment for depression following coronary artery disease. Our findings further highlight the clinical importance of exercise as a treatment as we see that it improves not only depression, but also other important aspects of heart disease, such as lowering blood pressure and cholesterol, in these patients."

"We continue to see emerging evidence of the importance of lifestyle to treat disease - in comparison to other treatments - but further high-quality research is needed. People with coronary heart disease who have symptoms of depression should talk to their doctor about treatments that are most suitable for their personal needs, and clinicians can be confident of recommending exercise to their patients."

Dr Frank Doyle and the study's senior authors, Prof. Jan Sorensen (Health Outcomes Research Centre, RCSI) and Prof. Martin Dempster (School of Psychology, Queen's University Belfast), conducted the study in collaboration with researchers in the USA, The Netherlands, the UK and Denmark.

This study was also the first of its kind to establish a new method to conduct systematic reviews known as a hybrid review, which is a combination of umbrella reviews and systematic reviews.

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RCSI

New study: Developers' skills and top management commitment lead to Agile project success

Around the globe, software-intensive organisations shift from plan-based development processes to Agile ones, intending to focus more on team interaction, better products, customers' needs, and readiness to change.

But how do these organisations succeed with large-scale Agile software transformations - and how do the success factors relate? This has been discussed in the scientific community for several years. Now, Associate Professor Daniel Russo from Department of Computer Science, Aalborg University presents a long-term study, which sheds even more light on the widespread phenomenon.

The study is accepted by the world-renowned journal ACM Transactions on Software Engineering and Methodology and has already generated attention from practitioners globally.

Not a shopping list

By combining a field study of a large-scale Agile transformation process at a notable Italian mission-critical organisation with a survey of 190 screened software engineers, Daniel Russo has developed an Agile Success Model. In the model, the roles of the stakeholders are clarified, and according to the author, the hope is that practitioners planning an Agile transformation can use the model to gain a deeper understanding of such a process.

- It is essential to say that this is not a shopping list or a recipe on how to be a success. Instead, I see this as a tool for organisations, teams and managers, providing them with an overview of which factors they should primarily focus on when planning or running an Agile transformation, Daniel Russo says.

He highlights the fact that the study is a combination of both qualitative and quantitative analysis. After generating hypothesis in the field, these have been validated through a large scale of professionals who actually use Scrum.

No difference between social and technical skills

So, what are the most critical constructs to project success? According to Daniel Russo, management should prioritise strengthening developers' skills:

- The failure or success of a software project highly relies on both the social and technical skills of the development team. There is no semantic difference between these set of skills. Being great at coding is not enough if you lack communication skills - and likewise, the other way around. This is a crucial consideration for hiring and setting up training programs.

At the same time, the roles of the middle management are of relatively smaller importance. Teams in Agile frameworks experience a relatively high degree of freedom to self-organise, and communication and collaboration are two pivotal activities in the groups.

Top management losses control

But the study also shows that providing an adequate organisational setting is even more critical for project success than just hiring socio-technically skilled developers:

- Project success mainly depends on the top management commitment. The top management has to welcome the fact that they will lose some degree of control over the development after the transformation, Daniel Russo says.

He points out that even though the field study was carried out among professionals who develop mission-critical software, the analysis shows that the model is non-domain specific and can be used in mission-critical and non-critical settings.

Meeting with Scrum.org

The results from Aalborg University supports the new direction of the Scrum Guide 2020, putting much more emphasis on the development side and downsizing middle management.

- The update of the guide was not performed following a scholarly investigation. In this perspective, our study is also a primary contribution to the practitioner's community by backing up the experience-based update of the most used Agile framework, Daniel Russo says.

Credit: 
Department of Computer Science, Aalborg University

Report calls for 'comprehensive action' to tackle poverty in UK city

Rising unemployment, inadequate benefits and low paid work are the main causes of poverty and destitution in Stoke-on-Trent according to the findings of a new study.

The research carried out by Staffordshire University and Citizens Advice Staffordshire North & Stoke-on-Trent, and funded through Research England's Strategic Priorities Fund, aims to understand the impact COVID-19 is having on residents in the city.

The report includes case studies of people who have turned to Citizens Advice and Alice Charity's Foodbank after finding themselves unable to work through the pandemic and facing increasing debt or struggling to claim benefits.

Post COVID-19 crisis and its impact on poverty and destitution in Stoke-on-Trent follows a report produced by Professor David Etherington for the Hardship Commission last year which examined the threat of the pandemic to Stoke-on-Trent's economy.

Ten months on, the new study includes updates the evidence and makes a number of recommendations on the "comprehensive action" needed to tackle the issues.

Professor David Etherington said: "Even before the COVID-19 crisis, Stoke-on-Trent was the 14th most deprived district in England with one of the highest rates of people on low pay and with low level skills. This has been exacerbated during the pandemic with the lowest paid, women, part-time workers and young people hit the hardest.

"A disturbing fact, given that Britain is one of the richest countries in the world, is that thousands of people in Stoke-on-Trent have insufficient incomes to meet basic needs and a consequence of this is that more and more people are turning to foodbanks for welfare support. The Alice Charity's foodbank reported that some parents are going without food for up to three days before coming to the foodbank. Another often-overlooked area is that people often do not take up the benefits they are entitled to."

The report highlights that:

across Stoke-on-Trent there are 50,228 persons of working age in-receipt of one or more benefits - 12,495 more than November 2019. This equates to an increase from 23.6% to 31.4% of the Working Age population.

even with the £20 'uplift', Universal Credit only amounts to the equivalent of 40% of average wages - £409.89 month for single person and £1112 per month for a couple with two children

young people claiming benefits in Stoke on Trent rose from 5.9% 2020 in March to 10.2 in December 2020.

over 90,000 people in Stoke-on-Trent and Newcastle-under-Lyme are in debt, struggling to pay their bills, keep up with their loan payments. Stoke-on-Trent has the 2nd highest rate of Debt Relief Orders (DROs) in England and Wales

the estimated total value of unclaimed benefits across the City is between £71.85m to £84.55m

hunger is now a key issue. Stoke-on-Trent Foodbank has provided food aid to 14,000 people in the last year (2020) and 1,500 received food aid who had never used a foodbank before. The Alice Charity's Foodbank provided more aid in the first two months of 2021 than in the whole of 2018.

The report also predicts a surge in demand for advice services as reported by Citizens Advice North Staffordshire and Stoke-on-Trent.

Simon Harris, Chief Executive Officer for Citizens Advice Staffordshire North and Stoke-on-Trent, said: "Before lockdown about 40 per cent of our Universal Credit clients were seen face to face and helped to make a claim. Many of these will not have successfully transferred to online channels due to poor digital skills and other factors and will have fallen through the net."

"Given that many more people have fallen behind with rent and bills and other payments over the pandemic, there is undoubtedly significant pent-up demand for debt advice and we anticipate a significant surge at some point in the next 12 months."

The report authors Professor David Etherington and Professor Martin Jones are now calling for action to address high levels of poverty and destitution experienced across the City.

Their recommendations include benefit take-up campaigns - similar to those adopted by the Scottish Government - which involve community groups, advice organisations and foodbanks working together to tackle the issue.

It also advocates using a Scandinavian style employment and training model (Jobrotation) to address unemployment and low skills.

Professor Jones said: "With fears of high unemployment in the UK following the COVID-19 pandemic and the phasing out of the Job Retention scheme, this is a critical time to be thinking about Jobrotation.

"Jobrotation is highly effective at providing opportunities for unemployed people to gain permanent jobs at the same time as upskilling existing employees. It could involve packaging funds from a range of programmes such as the Kickstart scheme, Universal Credit, Apprenticeships Levy and the UK Community Renewal Fund and we urge civic and business leaders to urgently explore these possibilities."

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Staffordshire University

Non-optimal codons enable coronaviruses' promiscuity

Since March 2020 the Cancer Genomics and BioComputing of Complex Diseases Laboratory at the Azrieli Faculty of Medicine of Bar-Ilan University has been dedicated to the study of COVID-19. Motivated in particular to study the evolution of coronaviruses, the lab, led by Dr. Milana Frenkel-Morgenstern, has characterized and compared sequences of numerous relevant viruses.

In their most recent study, published in the journal of the Federation of European Biochemical Societies (FEBS), the research team focused on patterns of genetic coding used by viruses which infect a single or narrow range of hosts compared to those which infect a multiple or broad range of hosts.

It was discovered that "promiscuous", or multiple-host, viruses utilize significantly non-optimal codons (the DNA sequences which encode amino acids of the protein) compared to single-host viruses. All of the coronaviruses adopt non-optimal codons to infect multiple hosts. However, instead of being weakly expressed, coronaviruses proteins have been observed to be highly expressed. This effect is provided by a special "trick" of coronaviruses which mitigate degradation which dramatically increase their viral mRNA load during infections.

"Our findings suggest that coronaviruses, with their vast reservoir in many animal species and their promiscuous behavior of infecting multiple hosts, should all be considered potential human pandemic viruses," says Dr. Frenkel-Morgenstern, who led the research with the assistance of Dr. Alessandro Gorohovski, Dr. Sumit Mukherjee and doctoral student Gon Carmi. "Our study also highlights that non-optimal codon usage of coronaviruses should be taken into account in SARS-CoV-2 vaccine development, as it may have a further effect on the structure and stability of proteins encoded by SARS-CoV-2."

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Bar-Ilan University

Saving the climate with solar fuel

image: By 2030, the retailer Lidl Switzerland will switch from fossil natural gas to liquefied renewable gas to operate its trucks.

Image: 
Lidl Switzerland

Mobility analyses show: Only a small proportion of all vehicles are responsible for the majority of the kilometers driven. We are talking above all about long-distance trucks that transport goods all over Europe. If these continue to be fueled with fossil energy, it will hardly be possible to sufficiently reduce CO2 emissions in road traffic. Synthetic fuels from surplus renewable electricity can make a significant contribution to such frequent driver applications.

With electric mobility, hydrogen mobility and synthetic fuels, Empa's future mobility demonstrator, "move", is investigating three paths for CO2 reduction in road traffic against the background of a rapidly changing energy system. "All these concepts have advantages and drawbacks in terms of energy, operation and economics. In order to use them in a smart way, we need a deeper understanding of the overall system," says Christian Bach, Head of Empa's Automotive Powertrain Technologies lab. "Together with our 'move' partners, we are working to develop knowledge that can be put into practice."

The latest project focuses on the production of synthetic methane from hydrogen and CO2 - the so-called methanization. Such fuels, produced synthetically with renewable energy - thus called synfuel or syngas -, can be transported via conventional routes and made available through the existing infrastructure. This is of interest for Switzerland as well as globally, because it opens up an enormous potential for renewable energy.

A methanization process developed at Empa

The basic chemical process of methanization has been known for over 100 years as the Sabatier reaction. In "move", another process developed further at Empa will be used: the so-called sorption-enhanced methanization. Empa researchers hope that this novel process engineering concept will lead to simpler process control, higher efficiency and better suitability for dynamic operation.
Methanization works as follows: Methane (CH4) and water (H2O) are produced by catalytic conversion from carbon dioxide (CO2) and hydrogen (H2). The water is causing problems with conventional processes, however: To remove it, serial methanization stages are typically required - with condensation areas in between. Due to the high reaction temperatures, a proportion of the water is converted back into hydrogen by the so-called water-gas shift reaction. The gaseous product of the methanization reaction thus contains a few percent hydrogen, which prevents direct feeding into the gas grid; the hydrogen must first be removed.

CO2 and water from the air

CO2 for the methanization as well as water for hydrogen production is taken directly from the atmosphere with a CO2 collector from the ETH spin-off Climeworks. The system sucks in ambient air and CO2 molecules remain attached to the filter. Using heat - around 100°C - the CO2 molecules can be released from the filter. Empa researchers see further potential for optimization in the heat required for this CO2 desorption. "Both hydrogen production and methanization continuously generate waste heat," says Bach. "By means of a clever heat management, we want to cover the heat requirements of the CO2 collector as much as possible with this waste heat". In addition to CO2, the Climeworks plant also extracts water from ambient air, which is used for hydrogen production in the electrolysis device. This means that such plants are also conceivable in regions without water supply, for example in deserts (see box).

In addition to new knowledge about technical and energetic aspects, insights about the economic efficiency of synthetic methane are one of the project's prime goals. "In order to ensure this holistic perspective, the project consortium consists of partners who cover the entire value chain - from Empa researchers to energy suppliers, filling station and fleet operators and industrial partners in the technology and plant sectors," says Brigitte Buchmann, member of Empa's Board of Directors and strategic head of "move". The project is supported by the Canton of Zurich, the ETH Board, Avenergy Suisse, Migros, Lidl Switzerland, Glattwerk, Armasuisse and Swisspower.

Currently, Christian Bach's team is concentrating on the investigation of water adsorption on porous materials and the process control of the catalytic reaction. Construction of the plant is planned for mid-2021. "About a year later, we want to refuel the first vehicle," says Buchmann. "With methane from solar energy."

Synthetic fuels from the desert?

When converting our energy system to renewable sources, there is a major challenge: Renewable sources such as sun or wind are not always available everywhere. In winter we have too little renewable energy, in summer there is too much - in the northern hemisphere. In the southern hemisphere it is the other way round. But there are also areas with almost continuous sunshine - the so-called sun belt, in which the large deserts of the Earth are located. "From a global perspective, we do not have too little renewable energy worldwide, but "merely" an energy transport problem," says Christian Bach. Synthetic energy carriers could help solve this problem.

Smaller plants in Switzerland can make a valuable contribution to the national energy system by harnessing surplus summer electricity and connecting different energy sectors. However, large plants could exploit their full potential above all in the Earth's sunbelt. This is illustrated by a simple calculation: In order to cover Switzerland's energy needs during winter not covered by hydropower as well as all long-distance domestic traffic exclusively with (imported) synthetic energy sources, a solar power plant would be required in a desert with an area of approximately 700 km2; that is 27 x 27 km or, in other words, 0.008% of the area of the Sahara. The water and CO2 needed for production could be extracted locally from the atmosphere (see main text). "Existing trade mechanisms, transport infrastructures, standards and expertise could simply be used further," says Bach. So could the plant in "move" soon be a model for a gigawatt plant in the desert?

Credit: 
Swiss Federal Laboratories for Materials Science and Technology (EMPA)

Researchers used smart watches to monitor changes in quality of life during lockdowns

image: Dr. Erez Shmueli

Image: 
Tel Aviv University

In a first-of-its-kind study, researchers from Tel Aviv University and the Academic College of Tel Aviv-Yaffo used smart watches and a dedicated app to monitor 169 subjects before and during Israel's second COVID-19 lockdown (October 2020). The watches and app provided the researchers with accurate daily data for measuring quality of life parameters, such as mood, stress, duration and quality of sleep, heart rate at rest, meeting others and physical exercise.

The study was conducted by a group of experts from the Iby and Aladar Fleischman Faculty of Engineering at Tel Aviv University led by Dr. Erez Shmueli, Dr. Dan Yamin, Shay Oved and Merav Mofaz, in collaboration with TAU's Prof. Noga Kronfeld Schor of the School of Zoology at the George S. Wise Faculty of Life Sciences and the Sagol School of Neuroscience, and Dr. Anat Lan and Prof. Haim Einat of the Academic College of Tel Aviv-Yaffo. The study was recently published at the leading Journal of the Royal Society Interface.

The data collected in the study indicate that, in general, during the lockdown the subjects slept more (6:08 vs. 6:01 hours) met fewer people face to face (11.5 vs. 7.8 daily encounters), exercised less (30 vs. 27 minutes), walked less (daily step count of 8,453 vs. 7,710) felt less happy (0.87 vs. 0.76 on a scale of -2 to 2) and exhibited a lower heart rate at rest (62.6 vs. 62.1 beats per minute).

Among the young participants, a more substantial drop was registered in the daily step count: from 9,500 steps before to 8,200 steps during the lockdown. In comparison, the average daily step count in the 60+ age group decreased from 7,500 to 7,200.

The lockdown was also very detrimental to the younger subjects' mood. On a scale of -2 to 2, their average score declined from 0.89 before to 0.72 during the lockdown, while older subjects reported only a small decrease - from 0.85 to 0.8.

Interestingly, when zooming in on the younger age group, the increase in sleep-duration was mainly expressed in late chronotypes (7:05 hours before vs. 7:24 during the lockdown). Late chronotypes, especially in the age of our younger group which usually work or study and have younger children (also in our study), normally suffer sleep loss. With no need to wake up the children or go to everyday obligations, the more relaxed social schedule induced by the lockdown could allow them to wake up later without using an alarm clock and increasetheir sleep duration. In contrast, when zooming in on the older age group, the increase in sleep-duration was mainly expressed in early chronotypes (6:48 hours before vs. 6:58 during the lockdown). It is possible that this population could not perform some early social activity like group sports, but other explanations may also be possible

Analysis by gender revealed that while men's stress level decreased from -0.79 before to -0.88 during the lockdown, women's stress rose from -0.62 to -0.52. The researchers suggest several possible explanations for these findings:

First, according to the Israeli Ministry of Finance, more women lost their workplace (fired or sent to unpaid vacation) than men. Second, schools and daycares were closed during lockdowns and parents to young children had to stay with them at home. Several studies reported that during lockdowns, men were more concerned about paid work while women were more worried about childcare. Third, according to Israeli Police data, domestic violence against women increased during lockdowns.

Moreover, the lockdown was more 'effective' in keeping women from meeting others face to face. While for men, the number of such encounters decreased from 11 to 9, women reported a sharper decline from 12 to 7 daily encounters on average. Face to face encounters, even a random meeting with a neighbor or a public transportation driver, are known to improve people's mood and reduce depression and anxiety.

"During lockdowns women were more secluded and stressed than men, and generally their welfare and mental health were significantly more affected than men's", adds Dr. Shmueli:

"We were lucky", says Dr. Shmueli. "Roughly two years before the outbreak of the pandemic, we planned a large-scale experiment with the goal of providing earlier and improved diagnosis of infected diseases, by integrating multiple sources of data such as self-reported questionnaires and smart watches. Clearly, we didn't have COVID-19 in our mind back then, but the running experiment allowed us to monitor subjects for a relatively long period before and during the second lockdown in Israel."

"The findings of our study are important by themselves and suggest that certain subpopulations should receive more attention than others during lockdowns. However, in addition to the direct negative effects of lockdowns on wellbeing, lockdowns may also indirectly affect our immune system - it is well known that mood, stress, physical activity and sleep duration and quality have a major effect on our immune system. Paying more attention to the affected subpopulations may therefore help in coping better with the virus, and even improve the effectiveness of vaccines."

"The COVID-19 crisis has channeled substantial resources to the wellbeing and welfare of the elderly, and rightly so, since they are more exposed than the younger population to the health hazards of the disease itself. But our study shows that emphasis should also be placed on the mental health of young people - who paid a heavier price for measures like social distancing and lockdowns."

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Tel-Aviv University

Study reveals changes in cigarette smoking during the COVID-19 pandemic

BOSTON - Last year, people who smoked had a variety of responses to the COVID-19 pandemic, with some increasing their smoking to help them cope and others quitting to potentially lessen their vulnerability to COVID-19. That's the finding of new research published in the Journal of General Internal Medicine and conducted by investigators at Massachusetts General Hospital (MGH), Vanderbilt University Medical Center and the University of Pittsburgh School of Medicine.

"Studies have shown that alcohol and opioid use increased during the pandemic, but little is known about how smokers responded," says lead author Nancy A. Rigotti, MD, director of MGH's Tobacco Research and Treatment Center and professor of Medicine at Harvard Medical School. "They might have increased their smoking due to stress and boredom. On the other hand, the fear of catching COVID might have led them to cut down or quit smoking. In fact, we found that both happened, and we examined reasons for both outcomes."

Rigotti and her colleagues analyzed survey responses from 694 current and former daily smokers--the average age was 53 years, 40% were male, and 78% were white--who had been hospitalized before the COVID-19 pandemic and had previously participated in a smoking cessation clinical trial at hospitals in Boston, Nashville and Pittsburgh. The survey was administered from May to July 2020.

Sixty-eight percent of respondents believed that smoking increases the risk of contracting COVID-19 or having a more severe case. This perceived risk was higher in Massachusetts (where COVID-19 had already surged) than in Pennsylvania and Tennessee. Higher perceived COVID-19 risk was associated with a higher interest in quitting smoking.

During the pandemic, 32% of respondents increased their smoking, 37% decreased their smoking, and 31% made no change. Those who increased their smoking tended to perceive more stress.

Also, 11% of respondents who smoked in January 2020 (before the pandemic) had quit smoking by the time the survey was administered (an average of six months later), while 28% of former smokers relapsed. Higher perceived COVID-19 risk was associated with a higher likelihood of quitting and a lower likelihood of relapse.

"Even before the pandemic, tobacco smoking was the leading preventable cause of death in the United States. COVID-19 has given smokers yet another good reason to stop smoking," says Rigotti. "Physicians, health care systems and public health agencies have an opportunity to educate smokers about their special vulnerability to COVID-19 and urge them to use this time to quit smoking for good."

"These messages will be more impactful if they guide smokers to programs like tobacco quitlines, which are available in every U.S. state and provide free counseling and medication to quit smoking," adds study co-leader Hilary Tindle, MD, MPH, founding director of ViTAL, the Vanderbilt Center for Tobacco, Addiction, and Lifestyle at Vanderbilt University Medical Center. Smokers can access tobacco quitlines by calling 1-800-QUIT-NOW. Smokers can also visit ICOVIDQuit.org to view short videos of peers who successfully quit smoking during the pandemic.

Credit: 
Massachusetts General Hospital

Feeling hot and bothered? It's complicated

image: Long-term trends of thermal discomfort, a measure of stress and discomfort induced by high temperatures and humidity, indicate that discomfort levels are actually decreasing in Saudi Arabia, despite rising global temperatures.

Image: 
© 2021 Morgan Bennett Smith

Rising temperatures are increasingly affecting the quality of life in many regions, setting new challenges for architects, urban planners and healthcare systems. Researchers at KAUST have analyzed discomfort due to outdoor heat across Saudi Arabia and neighboring regions to help understand and combat the problem.

"Living conditions in the Kingdom have been particularly affected by the changing climate," says Hari Dasari, first author of the paper. He also emphasizes the unique challenges facing the Hajj pilgrimage visits by several million people each year. Between 2014 and 2018, the Hajj occurred in summer months when the average temperature often exceeded 40 degrees Celsius with 80 percent humidity.

The team examined the variability and trends in a measure called the thermal discomfort index (DI), computed from temperature and humidity records collected from 1980 to 2018. The DI evaluates how these two factors combine to cause heat stress and discomfort.

Surprisingly, most cities in Saudi Arabia recorded an improvement in DI levels during the past 20 years, but significant exceptions were Yanbu, Makkah, Medina and Taif. The danger of increasing DI values in the Makkah region was confirmed by examining clinical records, which suggest a correlation with heat-related deaths during the Hajj pilgrimage.

"Many of us expected that the rising temperatures due to global warming and rapid growth in urbanization during recent decades should have reduced human comfort levels over KSA," says Dasari. A valuable insight from the research is the discovery that the situation is more complicated, with many regional variations worthy of further exploration.

Increased heat discomfort levels were concentrated mainly in neighboring regions of the Arabian Gulf, including the United Arab Emirates, Oman and Qatar.

Ibrahim Hoteit, leader of the research group, says the findings will help regional authorities, engineers and architects to plan the most effective developments in infrastructure, building design and healthcare interventions to improve safety and comfort across the region.

"We now plan to develop an atlas of DI values with risk maps indicating the trends through an online interactive visualization and analysis interface that provides real-time access for nonexpert users, and also a forecasting system to support the management of various outdoor activities and minimize health-related chronic symptoms." says Hoteit.

The team expect the further development of this research will also be critically important for supporting several large-scale projects currently being developed in Saudi Arabia, including the city of NEOM and the Red Sea Project and AMAALA tourism initiatives.

Credit: 
King Abdullah University of Science & Technology (KAUST)

Tracking RNA through space and time

image: One-cell zebrafish embryo: The MDC research lab found numerous localized genes at this early stage of development. Much of their genetic information flows into the precursor cells of the later germ cells.

Image: 
AG Junker, MDC

The "miracle of life" is most obvious at the very beginning: When the fertilized egg cell divides by means of furrows into blastomeres, envelops itself in an amniotic sac, and unfolds to form germ layers. When the blastomeres begin to differentiate into different cells - and when they eventually develop into a complete organism.

"We wanted to find out whether the later differences between the various cells are already partly hard-wired into the fertilized egg cell," says Dr. Jan Philipp Junker, who heads the Quantitative Developmental Biology Lab at the Berlin Institute for Systems Biology (BIMSB) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC). Junker and his team are investigating how cells make decisions and what dictates whether they become nerve, muscle, or skin cells. This involves creating cell lineage trees that allow them to determine the lineage and cell type of thousands of individual cells from an organism. Using these lineage trees, they can understand how and by what mechanisms cells come together to form a functioning organism or how they respond to perturbations.

Blueprints for different cell types already exist in the one-cell embryo

Yet this search for clues by means of cell lineage trees begins at a later stage - namely, when cell division and differentiation is already under way. What's more, the observations cover long time periods. In their current study, which has just been published in the journal "Nature Communications", Junker and his team focus on a very short time period: the first hours after fertilization, from the one-cell stage to the process of gastrulation - the formation of the germ layers - of the embryo. The scientists wanted to know whether the one-cell embryo already contains parts of the blueprint for the multitude of different cell types that later develop from it. To do this, they studied zebrafish and clawed frog embryos. Researchers had previously succeeded in finding individual genes whose RNA is localized at specific sites within one-cell zebrafish embryos. The Berlin scientists have now shown that there are many more such genes. "We have discovered ten times more genes whose RNA is spatially localized in the fertilized egg cell than previously known," explains Karoline Holler, lead author of the study. "Many of these RNA molecules are later transported into the primordial germ cells. This means that the program for subsequent cell differentiation is hard-wired into the fertilized egg cell."

New approaches in transcriptomics

State-of-the-art methods of single-cell transcriptomics provide a good understanding of cell differentiation. Scientists order individual cells according to the similarity of their transcriptome - the complete collection of RNA molecules present in a cell - and can use the patterns that emerge to decipher how the cells became what they are. However, they cannot use this method to reconstruct the earliest stages of embryonic development, because here the spatial arrangement of RNA molecules is crucial. His team instead used a specialized technique called tomo-seq, which Junker developed at the Hubrecht Institute in the Netherlands in 2014. It enables scientists to spatially track RNA molecules within the cell. This is achieved by cutting embryos of the model organisms into thin slices. It is then possible read the RNA profiles on the cut surfaces and convert them into spatial expression patterns. Holler refined the tomo-seq technique to now measure the spatial distribution of the transcriptome within the fertilized egg cell.

The scientists used another new technique to study which localized genes later contribute to which cells. "We labeled the RNA molecules so as to be able to track them over different developmental stages. This allows us to observe the RNA not only in space but also over time," explains Junker. In this way, the scientists can distinguish the RNA transferred to the embryo by the mother from the RNA produced by the embryo itself. This RNA labeling method, called scSLAM-seq, was fine-tuned at BIMSB in the labs of Professor Markus Landthaler and Professor Nikolaus Rajewsky, enabling it to be applied in living zebrafish. "Labeling RNA molecules allows us to measure with high precision how gene expression changes in individual cells, for example, after an experimental intervention," explains Junker.

How do drugs affect cell differentiation?

RNA labeling opens up completely new avenues for studying such things as the mechanism of action of drug therapies. "We can use it in organoids to investigate how different cell types respond to substances," explains the physicist. The method, Junker says, is not suitable for long-term processes of change. "But we can see which genes change within five to six hours after treatment, providing a pathway to understanding how we might influence cell differentiation."

Spatial analysis also has medical relevance: Looking further into the future, it could be useful for studying those diseases that result from mislocalized RNA, such as cancer or neurodegenerative diseases. In such diseases a large number of molecules are transported through the cell. "If we understand these transport processes, then we may be able to identify risk factors for these diseases," explains Holler. But, for now, that is a long way off. "There is still much work to be done before the one-cell zebrafish embryo can be used as a model system for studying human neurodegenerative diseases," stresses Junker.

The scientists next want to uncover the mechanisms involved in RNA localization: How does the detected RNA differ from other transcripts in the cell? Junker's team plans to work with Professor Irmtraud Meyer's lab at BIMSB to characterize the sequence features of the localized RNA. With the help of algorithms, they hope to predict whether the localized genes share a two- or three-dimensional fold. They are also working on further developing their method so that it can be used in other systems than the one-cell zebrafish embryo.

Credit: 
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Food systems offer huge opportunities to cut emissions, study finds

image: Greenhouse-gas contributions from various parts of the global food system.

Image: 
From Tubiello et al., Environmental Research Letters 2021

A new global analysis says that greenhouse-gas emissions from food systems have long been systematically underestimated--and points to major opportunities to cut them. The authors estimate that activities connected to food production and consumption produced the equivalent of 16 billion metric tons of carbon dioxide in 2018--one third of the human-produced total, and an 8 percent increase since 1990. A companion policy paper highlights the need to integrate research with efforts to reduce emissions. The papers, developed jointly by the UN Food and Agriculture Organization, NASA, New York University and experts at Columbia University, are part of a special issue of Environmental Research Letters on sustainable food systems.

The Center on Global Energy Policy has also produced a detailed guide to food systems and climate, and a related video, both geared to the general public.

The lead author of the analysis, Francesco Tubiello, heads the environment statistics unit at FAO. He said the study shows that food production represents a "larger greenhouse-gas mitigation opportunity than previously estimated, and one that cannot be ignored in efforts to achieve the Paris Agreement goals." He said emissions inventories that countries currently report to the United Nations Framework Convention on Climate Change poorly characterize food systems, and underestimate their contribution to climate change.

The study provides country-level datasets that are being refined ahead of the UN's Food Systems Summit, to be held in July. It considers emissions linked not just to production of livestock and crops, but from land-use changes at the boundary between farms and natural ecosystems, and from related manufacturing, processing, storage, transport and waste disposal.

The companion policy piece calls for better scientific understanding of the processes through which greenhouse gases are emitted from all phases of food production and consumption. It says that the food system has a major role to play in mitigating climate change. The lead author of that paper, Cynthia Rosenzweig of Columbia University's Earth Institute and the NASA Goddard Institute for Space Studies, said, "Science and policy domains have often been siloed in academia. We propose a 'double helix' of interactive research by scientists and policy experts that can deliver significant benefits for both climate change and the food system."

"The food system and the climate system are deeply intertwined," said coauthor David Sandalow, a fellow at Columbia's Center on Global Energy Policy. "Better data can help lead to better policies for cutting emissions and protecting the food system from a changing climate."

Programs and policies to mitigate climate change must consider the impact on the more than 500 million smallholder households around the world, say the authors. This issue is particularly acute in the least-developed countries, where relatively larger shares of the population rely on agriculture for their livelihoods, they say.

"To achieve a net-zero future, we need to understand better the interplay between the food system and emissions in developing countries where populations are growing, poverty is diminishing, and incomes are rising," said Philippe Benoit, an adjunct senior research scholar at the Center on Global Energy Policy.

One emergent theme: optimal mitigation strategies will require a focus on activities both before and after farm production, ranging from the industrial production of fertilizers to refrigeration at the retail level. Emissions from these activities are growing fast.

"Agriculture in developed countries emits large quantities of greenhouse gases, but their share can be obscured by large emissions from other sectors like electricity, transportation and buildings," said Matthew Hayek, an assistant professor in environmental studies at New York University and coauthor of both pieces. "Looking at the entire food system can not only illuminate opportunities to reduce emissions from agriculture, but also improve efficiency across the whole supply chain with technologies such as refrigeration and storage."

The study found that while total food-systems emissions rose from 1990 to 2018, growing populations and changing technologies meant that per capita emissions actually decreased, from the equivalent of 2.9 metric tons to 2.2 metric tons per person. But per capita emissions in developed countries, at 3.6 metric tons per person in 2018, were nearly twice those in developing countries.

The conversion of natural ecosystems to agricultural croplands or pastures remained the largest single emissions source over the study period, at nearly 3 billion metric tons per year. But it declined significantly over time, by over 30 percent, possibly in part because we are running out of land to convert.

On the other hand, global emissions from domestic food transportation have increased by nearly 80 percent since 1990, to 500 million tons in 2018. Those emissions have nearly tripled in developing countries. And emissions generated by food system energy use, largely carbon dioxide from fossil fuels along the supply chain, amounted to over 4 billion tons in 2018, an increase of 50 percent since 1990.

Credit: 
Columbia Climate School

'Camouflage breakers' can find a target in less than a second

image: Dr. Jay Hegdé and first author Fallon Branch.

Image: 
Michael Holahan, Augusta University

After looking for just one-twentieth of a second, experts in camouflage breaking can accurately detect not only that something is hidden in a scene, but precisely identify the camouflaged target, a skill set that can mean the difference between life and death in warfare and the wild, investigators report.

They can actually identify a camouflaged target as fast and as well as individuals identifying far more obvious "pop-out" targets, similar to the concept used at a shooting range, but in this case using easy-to-spot scenarios like a black O-shaped target among a crowd of black C shapes.

In fact, the relatively rapid method for training civilian novices to become expert camouflage breakers developed by Medical College of Georgia neuroscientist Dr. Jay Hegdé and his colleagues, also enabled the camouflage breakers to sense that something was amiss even when there was no specific target to identify.

This intuitive sense that something is not quite right has also been found in experienced radiologists finding subtle changes in mammograms, sometimes years before there is a detectable lesion.

The MCG investigators who developed the camouflage breaking technique wanted to know if trainees could detect the actual camouflaged target or just sense that something is different, an issue that is highly significant in real world circumstances, where a sniper might be hiding in the desert sand or a dense forest landscape.

"Merely being able to judge, no matter how accurately, that the given combat scene contains a target is not very useful to a sniper under real-world combat conditions if he/she is unable to tell where the target is," Hegdé and his colleagues write in the journal Cognitive Research: Principles and Implications.

They already knew that they could train most nonmilitary individuals off the street to break camouflage in as little as an hour daily for two weeks as long as their vision is good, a finding they want to benefit military personnel.

"We want to hide our own personnel and military material from the enemy and we want to break the enemy's camouflage," says Hegdé, goals that summarize his research, which has been funded by the Army Research Office, an element of the U.S. Army Combat Capabilities Development Command Army Research Laboratory, for nearly a decade. "What are the things we can tweak? What are the things we can do to make our snipers better at recognizing camouflage?"

Because a missed shot by a sniper also tells the enemy his location. "You can't take shots at things that are not the target," Hegdé says.

"The potential for rapid training of novices in the camouflage-breaking paradigm is very promising as it highlights the potential for application to a wide variety of detection and localization tasks," says Dr. Frederick Gregory, program manager, U.S. Army Combat Capabilities Development Command Army Research Laboratory. "Results in experts highlight an opportunity to extend the training to real world visual search and visualization problems that would be of prime importance for the Army to solve."

For this newly published work, six adult volunteers with normal or corrected-to-normal vision were trained to break camouflage using Hegdé's deep-learning method, but received no specific training about how to pinpoint the target. Participants looked at digitally synthesized camouflage scenes like foliage or fruit and each scene had a 50-50 chance of containing no target versus a camouflaged target like a human head or a novel, 3D digital image. Similar to computer scientists training self-driving cars, the idea was and is to get viewers to get to know the lay of the land that is their focus. "If it turns out there is something that doesn't belong there, you can tell," he says.

Trainees could then either look at the image for 50 milliseconds --.05 seconds -- or as long as they wanted, then proceed to the next step where they quickly viewed a random field of pixels, that work like a visual palate cleanser, before acknowledging whether the camouflage image contained a target, then using a mouse to show where the target was. "You have to work from memory to say where it was," he notes.

When the participants could look at the image for as long as they wanted, the reported location of the actual target was essentially indistinguishable from the actual target but the accuracy did not drop much when the viewing time was just 50 milliseconds, which gives little time for even moving your eyes around, Hegdé says.

The subjects again had no subsequent training on identifying precisely where the target was. And they found that even without that specific training, they could do both equally well. "This was not a given," Hegdé notes.

In a second experiment with seven different individuals they used a much-abbreviated training process, which basically ensured participants knew which buttons to push when, and used instead a clearly more pronounced "pop-out' target without the traditional camouflage background, rather scenarios like that black O-shaped target among a crowd of black C shapes or a blue S shape among a sea of green H shapes. Both the longer and shorter viewing times yielded essentially identical results from the more extensively trained camouflage-breakers, both in accuracy of localization and reaction time.

Camouflage is used extensively by the military, from the deserts of the Middle East to the dense jungles of South America with the visual texture changing to blend with the natural environment. "You often are recognized by your outline, and you use these patterns to break up your outline, so the person trying to break your camouflage doesn't know where you leave off and the background begins," he says.

He notes that context is another important factor for recognition, referencing how you may not recognize a person whose face you have seen multiple times when you see them in a different environ. His current Army funded studies include exploring more about the importance of context, and further exploring ramifications of "camouflage breaking" in identifying medical problems.

He notes that even with his training, some people are better at breaking camouflage than others -- he says he is really bad at it -- and why remains mostly a mystery and another learning point for Hegdé and his colleagues.

Credit: 
Medical College of Georgia at Augusta University

Study identifies major barriers to financing a sustainable ocean economy

image: Summary of major capital types, level of risk vs. return for each capital type and the key providers of these types. (Fig. 1)

Image: 
Patricia Tiffany Angkiriwang

Financing a sustainable global ocean economy may require a Paris Agreement type effort, according to a new report from an international team of researchers led by the University of British Columbia.

That's because a significant increase in sustainable ocean finance will be required to ensure a sustainable ocean economy that benefits society and businesses in both developing and developed countries.

The report, published today - on World Ocean Day - identifies major barriers to financing such a sustainable ocean economy. This includes all ocean-based industries, like seafood production, shipping and renewable energy, and ecosystem goods and services, such as climate regulation and coastal protection.

"The size of the ocean economy was estimated at around USD $1.5 trillion in 2010, and prior to the COVID-19 pandemic, was projected to increase to USD $3 trillion in 2030," said lead author Dr. Rashid Sumaila, a professor at UBC's Institute for the Oceans and Fisheries and the School of Public Policy and Global Affairs and Canada Research Chair in Interdisciplinary Ocean and Fisheries Economics.

"But a sustainable ocean economy requires healthy and resilient marine ecosystems, which are being severely threatened by anthropogenic and climate pressures," said Dr. Sumaila. "There are many opportunities for governments, financial institutions and other players to make financial gains in this type of sustainable economy -- but there are also many barriers that need to be overcome."

Four major barriers identified in the study include:

1. A weak enabling environment for attracting sustainable ocean finance;

2. Insufficient public and private investment in the ocean economy due to a lack of high quality, investible projects with appropriate deal size and risk-return ratios to match available capital;

3. A limited ability of people to visualize and develop projects that are attractive to investors; and

4. The higher relative risk profile of ocean investments, where the enabling environment for insurance and risk mitigation is also not in place.

Currently, there is a shortfall in financing a sustainable ocean economy. According to the researchers, governments and public institutions may be a good place to start, in order to close this gap.

"There is scope for raising money from the uses of the ocean, and for part of this to be used to improve its management," said Dr. Sumaila. "The gap in conservation financing for all ecosystems, which includes funds for a sustainable ocean economy, was estimated at USD $300 billion globally. That is less than one per cent of the global GDP. Can you imagine what we would have available if governments made two or three per cent available?"

This would lead to financial institutions being incentivised to invest, and to the development of an enabling environment with private sector actors who are interested in encouraging green ventures that foster ocean development.

"And then you get insurance companies involved, because working in the ocean is generally riskier than working on land," said Dr. Louise Teh, a research associate at the Institute for the Oceans and Fisheries.

The report's authors point to public-private partnerships that have had significant results, including special green investments funds offered by the Netherlands that are exempt from income tax, thus allowing investors in green projects - such as green shipping - to contract loans at reduced interest rates.

"These Dutch green funds have already attracted more investment than can be utilized in the available schemes - an encouraging sign for the future prospects of such instruments," said Dr. Sumaila.

The cost of inaction regarding the conservation and sustainable use of the ocean is high.

"If we carry on with 'business as usual' we still face the cost of coastal protection, relocation of people and loss of land to sea level rise - a cost that is projected to rise from USD $200 billion to a trillion USD annually by 2100," said Dr. Sumaila. "The centrality of adequate finance to ensure a sustainable ocean economy is such that the world may need a Paris Agreement type effort to meet the needs."

"Financing a sustainable ocean economy" was published in Nature Communications.

Credit: 
University of British Columbia

Monarchs raised in captivity can orient themselves for migration, U of G study reveals

image: A monarch is fitted with a radio tracker

Image: 
Alana Wilcox

Monarch butterflies raised indoors still know how to fly south if given enough time to orient themselves, according to new University of Guelph research.

The finding is good news for the many nature lovers and school students who raise monarchs and then set them free to help boost struggling numbers.

Monarchs are the only butterfly known to make a long-distance migration to warmer wintering grounds. While those born in the spring and early summer live only from two to six weeks, those that emerge in the late summer sense environmental signals that tell them to fly thousands of kilometres south, to central Mexico.

Recent U.S. studies have suggested that captive-raised monarchs become disoriented when they emerge from their cocoons and cannot fly south. But this new research, led by U of G PhD student Alana Wilcox and integrative biology professor Dr. Ryan Norris, finds that may not be true.

Wilcox said previous research was conducted only in a "flight simulator," involving placing the butterflies into an open vessel and then gauging which direction they try to fly. The U of G team used a flight simulator but also tracked a second group of monarchs that were released in the wild after being equipped with tiny radio transmitters.

Those butterflies showed proper southward orientation, if given enough time to get their bearings.

"We believe the reason why the monarchs released in the wild flew in the proper direction is likely because they had time to calibrate their internal compasses after being released, which ensured they flew in a southerly direction," said Norris.

The new study appears in the journal Conservation Physiology. Integrative biology professor Dr. Amy Newman and Dr. Nigel Raine, a professor in U of G's School of Environmental Sciences, contributed to the research.

The team came upon the finding almost by accident. They had been investigating whether monarch caterpillars raised on milkweed grown in soil with a neonicotinoid pesticide would have trouble migrating once they moulted into butterflies.

They found the pesticide did not appear to affect the butterflies' migration. But they noticed differences between the monarchs tested in the flight simulator and those that had been raised in the same conditions and released in the wild with radio transmitters.

Only 26 per cent of monarchs tested in the flight simulator (10 of 39 butterflies) showed a weak southward orientation after several minutes of testing; the rest flew in all directions. But almost all the radio-tracked butterflies (28 of 29, or 97 per cent) flew in a south-to-southeast direction from the release site and were detected at distances of up to 200 kilometres away.

"Our results suggest that although captive rearing of monarch butterflies may cause temporary disorientation for monarchs, once butterflies have been exposed to sunlight and natural skylight cues, they can establish proper orientation using their sense of proper flight direction," Wilcox said.

This process of orientation after release from captivity can take between 24 and 48 hours, added Norris.

The findings are good news for the thousands of butterfly enthusiasts and educators concerned that raising endangered monarchs in captivity might hamper their instinct to fly to their wintering grounds in Mexico.

The team notes the findings apply only to late-summer monarchs, which perceive environmental cues such as shorter days as signs that it's time to migrate to Mexico.

"Though the environmental conditions in our experiment might differ for monarchs reared by hobbyists, our results suggest that captive rearing remains a valuable educational tool for highlighting the natural history and biology of butterflies," said Norris.

Credit: 
University of Guelph

Mechanochemical peptide bond formation behind the origins of life

image: T. Stolar, K. Užarevi?, José G. Hernández.

Image: 
RBI

The presence of amino acids on the prebiotic Earth is widely accepted, either coming from endogenous chemical processes or being delivered by extraterrestrial material. On the other hand, plausibly prebiotic pathways to peptides often rely on different aqueous approaches where condensation of amino acids is thermodynamically unfavorable. Now, chemists from the Ruđer Bošković Institute (RBI), in collaboration with colleagues from Xellia Pharmaceuticals, have shown that solid-state mechanochemical activation of glycine and alanine in combination with mineral surfaces leads to the formation of peptides.

This research shows for the first time the usefulness of mechanochemical activation for the prebiotic synthesis of larger biomolecules such as peptides. The results of the research have been published in the prestigious scientific journal Angewandte Chemie.

Prebiotic chemistry studies chemical transformations in conditions plausible for early Earth (approximately before 4,3-3,7 billion years ago) that could have led to life. Since the surface of the Earth has been changing by different geological processes over time, there is no historical evidence that would unambiguously explain how life appeared.

It is generally considered that from the primordial chemical inventory, more complex molecules emerged by chemical evolution which subsequently led to life.

Reaction conditions that are accepted as plausible are aqueous media, water/rock interfacial interactions, and a solid-state environment absent of water.

Prebiotic sources of mechanical energy on the prebiotic Earth likely included impacts, erosion, weathering, tectonics, and earthquakes, whereas geothermal settings provided the local inputs of thermal energy.

Peptide bond formation is one of the key chemical transformations in the field of prebiotic chemistry. It is regarded that peptides played an important catalytic role in the formation of other biomolecules and were included in primordial molecular symbiosis with nucleic acids. Current strategies for the prebiotic peptide bond synthesis rely on α-aminonitrile ligation in water and the use of wet/dry cycles for the condensation of amino acids.

Researchers from the RBI: Dr. José G. Hernández, Dr. Krunoslav Užarević, and PhD student Tomislav Stolar, in collaboration with scientists from Xellia; Dr. Ernest Meštrovi, PhD student Saša Grubeši and Dr. Nikola Cindro from the Chemistry Department of the Faculty of Science (University of Zagreb), have shown that mechanochemical prebiotic peptide bond formation occurs in the absence of water.

The team discovered that mechanochemical ball-milling of glycine in the presence of minerals such as TiO2 and SiO2 leads to the formation of glycine oligomers. If the reaction mixture is simultaneously heated using the thermally controlled ball-milling, glycine oligomers up to Gly11 are obtained (11 residues of glycine).

Experiments with diketopiperazine (DKP), diglycine, and triglycine showed that mechanochemical peptide bond formation is a dynamic and reversible process with simultaneous making and breaking of peptide bonds.

Notably, ball-milling of glycine and L-alanine mixture results in the formation of their hetero-oligopeptides. High-performance liquid chromatography (HPLC) and mass spectrometry (MS) were used to analyze the reaction products.

Long oligomers of glycine obtained through a mechanochemical pathway might have offered access to a more diverse library of peptides on the prebiotic Earth through chemical modifications such as α-alkylation. The results of this study complement the existing experimental procedures in prebiotic chemistry and offer an alternative synthetic pathway to peptides that is absent of water.

"The origin of life question is one of the most important ones in science and requires an interdisciplinary approach to study it. Therefore, space agencies such as NASA and JAXA invest great resources to acquire new fundamental insights. For example, recent Hayabusa2 and OSIRIS-REx asteroid sampling missions will offer clues into the chemical inventory available during the time when life emerged on Earth.

First-ever samples of the asteroid were brought back to Earth in December of 2020 and more are expected in 2023. Together with the identification of extraterrestrial materials in those samples, it is important to conduct laboratory experiments that would explain their presence and formation mechanism. Such fundamental studies can then be applied in modern synthetic chemistry." says Tomislav Stolar, first author of the publication.

Credit: 
Ruđer Bošković Institute