Brain

New perspective needed for role of major Alzheimer's gene

Scientists' picture of how a gene strongly linked to Alzheimer's disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found.

People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer's disease compared with those who have other variations of the gene.

Live and learn

ANN ARBOR---More than one in every 10 members of Generation X are enrolled in classes to continue their formal educations, according to a new University of Michigan study released today. In addition, 48 percent of GenXers take continuing education courses, in-service training, and workshops required for professional licenses and certifications.

"This is an impressive level of engagement in lifelong learning," says Jon D. Miller, author of the latest issue of The Generation X Report. "It reflects the changing realities of a global economy, driven by science and technology.

Anti-depressant link to Clostridium difficile infection

Certain types of anti-depressants have been linked to an increase in the risk of Clostridium difficile infection (CDI) finds a study in BioMed Central's open access journal BMC Medicine. Awareness of this link should improve identification and early treatment of CDI.

Skipping meals and shopping sabotages diets

Skipping meals can sabotage your shopping – and your diet, according to a new Cornell study. Even short term food deprivation not only increases overall grocery shopping, but leads shoppers to buy 31% more high calorie foods.

Effects of stress on brain cells offer clues to new anti-depressant drugs

Research from King's College London reveals the detailed mechanism behind how stress hormones reduce the number of new brain cells - a process considered to be linked to depression. The researchers identified a key protein responsible for the long-term detrimental effect of stress on cells, and importantly, successfully used a drug compound to block this effect, offering a potential new avenue for drug discovery.

Bats use blood to reshape tongue for feeding

PROVIDENCE, R.I. [Brown University] — Nectar-feeding bats and busy janitors have at least two things in common: They want to wipe up as much liquid as they can as fast as they can, and they have specific equipment for the job. A study in the Proceedings of the National Academy of Sciences describes the previously undiscovered technology employed by the bat Glossophaga soricina: a tongue tip that uses blood flow to erect scores of little hair-like structures exactly at the right time to slurp up extra nectar from within a flower.

Preclinical study shows heroin vaccine blocks relapse

LA JOLLA, CA – Scientists at The Scripps Research Institute (TSRI) have reported successful preclinical tests of a new vaccine against heroin. The vaccine targets heroin and its psychoactive breakdown products in the bloodstream, preventing them from reaching the brain.

Traumatized moms avoid tough talks with kids, Notre Dame study shows

Mothers who have experienced childhood abuse, neglect or other traumatic experiences show an unwillingness to talk with their children about the child's emotional experiences, a new study from the University of Notre Dame shows.

Monell scientists identify critical link in mammalian odor detection

PHILADELPHIA (May 6, 2013) – Researchers at the Monell Center and collaborators have identified a protein that is critical to the ability of mammals to smell. Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally anosmic – unable to smell. The findings may lend insight into the underlying causes of certain smell disorders in humans.

Weight gain linked with personality trait changes

People who gain weight are more likely to give in to temptations but also are more thoughtful about their actions, according to a new study published in Psychological Science, a journal of the Association for Psychological Science.

To understand how fluctuations in body weight might relate to personality changes, psychological scientist Angelina Sutin of the Florida State University College of Medicine and colleagues at the National Institutes of Health (NIH) examined data from two large-scale longitudinal studies of Baltimore residents.

Traumatic brain injury poses complex diagnostic, management and treatment challenges in older people

Amsterdam, NL, May 6, 2013 – Each year more than 1.7 million people in the United States sustain a traumatic brain injury (TBI). The incidence of TBI in older adults poses special diagnostic, management and treatment challenges, say experts in a special collection of papers on TBI in the elderly in NeuroRehabilitation: An Interdisciplinary Journal.

Commands from the matrix

Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix. Researchers at the Ruhr-Universität have found evidence that this complex network of molecules controls the formation and activity of the neuronal connections. The team led by Dr. Maren Geißler und Prof.

Researchers reveal new more precise method of performing electroconvulsive therapy

Philadelphia, PA, May 6, 2013 - Electroconvulsive therapy (ECT) is the most effective acute treatment for severe major depression. However, even with newer forms of ECT, there remains a significant risk of adverse cognitive effects, particularly memory problems.

The nocebo effect: Media reports may trigger symptoms of a disease

Media reports about substances that are supposedly hazardous to health may cause suggestible people to develop symptoms of a disease even though there is no objective reason for doing so. This is the conclusion of a study of the phenomenon known as electromagnetic hypersensitivity. Those affected report experiencing certain symptoms on exposure to electromagnetic waves, such as those emitted by cell phones, and these take the form of physical reactions.

LCSB discovers endogenous antibiotic in the brain

Luxembourg, 6 May 2013 – Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have discovered that immune cells in the brain can produce a substance that prevents bacterial growth: namely itaconic acid. Until now, biologists had assumed that only certain fungi produced itaconic acid. A team working with Dr. Karsten Hiller, head of the Metabolomics Group at LCSB, and Dr. Alessandro Michelucci has now shown that even so-called microglial cells in mammals are also capable of producing this acid. "This is a ground breaking result," says Prof. Dr.