Brain

Huntington's disease (HD) is characterized by ongoing destruction of specific neurons within the brain. It affects a person's ability to walk, talk, and think - leading to involuntary movement and loss of muscle co-ordination. New research published in BioMed Central's open access journal Molecular Neurodegeneration shows that the RyanR inhibitor Dantrolene is able to reduce the severity of walking and balance problems in a mouse model of HD.

This release is available in Polish.

A new study has revealed that immature neurons taken from healthy mouse embryos can repair damaged brain circuitry and partially normalize metabolism when transplanted into adult mice that have grown morbidly obese due to a genetic deficiency. This proof-of-principle discovery represents one step down a long road toward neuronal replacement therapy, which researchers hope might one day be used to repair brains that have been injured by trauma or disease.

BOSTON, MA -- Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was widely believed.

We rely on our doctors to make appropriate decisions for our treatment, but this process can be subject to a variety of potentially conflicting influences. To identify what makes a good decision-maker, a team of researchers, led by Read Montague, PhD, director of the Human Neuroimaging Laboratory at Virginia Tech Carilion Research Institute, tested 35 experienced physicians for their ability to make appropriate treatment choices, and found that the doctors who performed best were those who learned from both their successes and failures, rather than focusing just on the successful outcomes.

When seeking a physician, you should look for one with experience. Right? Maybe not. Research on physicians' decision-making processes has revealed that those who pay attention to failures as well as successes become more adept at selecting the correct treatment.

JUPITER, FL, November 23, 2011 – Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes.

A healthy diet and the right amount of exercise are key players in treating and preventing obesity but we still know little about the relationship both factors have with each other. A new study now reveals that an increase in physical activity is linked to an improvement in diet quality.

SINC

Many questions arise when trying to lose weight. Would it be better to start on a diet and then do exercise, or the other way around? And how much does one compensate the other?

Glioblastoma is regarded as the most malignant form of brain tumor. In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. To at least slow down the growth of tumor cells that have remained in the head, almost all glioblastoma patients are treated by radiotherapy after surgery.

PASADENA, Calif. -- Although many mental illnesses are uniquely human, animals sometimes exhibit abnormal behaviors similar to those seen in humans with psychological disorders. Such behaviors are called endophenotypes. Now, researchers at the California Institute of Technology (Caltech) have found that mice lacking a gene that encodes a particular protein found in the synapses of the brain display a number of endophenotypes associated with schizophrenia and autism spectrum disorders.

In the 19th century, Francis Galton noted that certain people who were otherwise normal "saw" every number or letter tinged with a particular color, even though it was written in black ink. For the past two decades researchers have been studying this phenomenon, which is called synesthesia.

How does awareness influence information processing during decision making in the human brain? A new study led by Floris de Lange of the Donders Institute for Brain, Cognition and Behaviour at Radboud University Nijmegen, offers new insight into this question, and is published November 22 in the online, open-access journal PLoS Biology.

(Boston) – Researchers at Boston University School of Medicine (BUSM) have, for the first time, identified an intracellular signaling enzyme that regulates the wake-sleep cycle, which could help lead to the development of more effective sleep aid medications. Subimal Datta, PhD, director and principle investigator at the Laboratory of Sleep and Cognitive Neuroscience at BUSM, led the study, which points to a specific enzyme inside neurons in the brain that trigger an important shift in consciousness from sleep to wakefulness and wakefulness to sleep.

Madison, Wis. — Images of prisoners' brains show important differences between those who are diagnosed as psychopaths and those who aren't, according to a new study led by University of Wisconsin-Madison researchers.

The results could help explain the callous and impulsive anti-social behavior exhibited by some psychopaths.

Los Angeles, CA (November 22, 2011)) According to new research, wine promoters may want to spend more money on brochures and flyers and less money on wine tastings as they market to novice wine drinkers. A recent study published in Cornell Hospitality Quarterly (a SAGE journal) finds that without teaching about the background and process of wine production, new wine drinkers can be more easily influenced by advertising to make their purchases than their experienced counterparts.

New Rochelle, NY -- Bioengineering -- the application of engineering principles to understand and treat medical conditions -- is delivering innovative solutions for diagnosing and repairing damage to the brain caused by a traumatic injury. A broad sample of these new, cutting-edge techniques is presented in a special issue of Journal of Neurotrauma, a peer-reviewed journal published by Mary Ann Liebert, Inc.