Brain

The inexorable spread of Alzheimer's disease through the brain leaves dead neurons and forgotten thoughts in its wake. Researchers at Linköping University in Sweden are the first to show how toxic proteins are transferred from neuron to neuron.

Through experiments on stained neurons, the research team – under the leadership of Martin Hallbeck, associate professor of Pathology – has been able to depict the process of neurons being invaded by diseased proteins that are then passed on to nearby cells.

Putnam Valley, NY. (June 26 , 2012) –Researchers in Japan who evaluated the risks and efficacy of transplanting two varieties of stem cells into mouse cochlea have concluded that both adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities. However, there is a risk of tumor growth associated with transplanting iPS cells into mouse cochleae. Given the potential for tumorigenesis, they concluded that the source of iPS cells is a critical issue for iPS cell-based therapy.

Putnam Valley, NY. (June 26 , 2012) – Optimal stem cell therapy delivery to damaged areas of the heart after myocardial infarction has been hampered by inefficient homing of cells to the damaged site. However, using rat models, researchers in France have used a magnet to guide cells loaded with iron oxide nanoparticles to key sites, enhancing the myocardial retention of intravascularly delivered endothelial progenitor cells.

BOSTON – Magnetic fields generated by microscopic devices implanted into the brain may be able to modulate brain-cell activity and reduce symptoms of several neurological disorders. Micromagnetic stimulation appears to generate the kind of neural activity currently elicited with electrical impulses for deep brain stimulation (DBS) – a therapy that can reduce symptoms of Parkinson's disease, other movement disorders, multiple sclerosis and chronic pain – and should avoid several common problems associated with DBS, report Massachusetts General Hospital investigators.

A picture may be worth a thousand calories, a new study suggests. Looking at images of high-calorie foods stimulates the brain's appetite control center and results in an increased desire for food, according to the study, which will be presented Monday at The Endocrine Society's 94th Annual Meeting in Houston.

"This stimulation of the brain's reward areas may contribute to overeating and obesity," said the study's senior author, Kathleen Page, MD, assistant professor at the University of Southern California, Los Angeles.

A new video article in JoVE, the Journal of Visualized Experiments, describes a novel procedure to monitor brain function and aid in functional mapping of patients with diseases such as epilepsy. This procedure illustrates the use of pre-placed electrodes for cortical mapping in the brains of patients who are undergoing surgery to minimize the frequency of seizures. This technique, while invasive, provides real-time analysis of brain function at a much higher resolution than current technologies.

The MacArthur Research Network on Youth and Participatory Politics (YPP), under the direction of co-principal investigators University of Chicago political scientist Cathy Cohen, and Joseph Kahne, professor of education at Mills College, has unveiled the findings of the largest nationally representative study to date of new media and politics among young people.

Prenatal exposure to the environmental contaminants polychlorinated biphenyls, or PCBs, causes long-term changes to the developing brain that have adverse effects on reproductive function later in life, a new study finds. Results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

PROVIDENCE, R.I. – Rhode Island Hospital researcher Suzanne de la Monte, M.D., has found a link between brain insulin resistance (diabetes) and two other key mediators of neuronal injury that help Alzheimer's disease (AD) to propagate. The research found that once AD is established, therapeutic efforts must also work to reduce toxin production in the brain. The study, Dysfunctional Pro-Ceramide, ER Stress, and Insulin/IGF Signaling Networks with Progression of Alzheimer's Disease, is published in the June 22, 2012, supplement of the Journal of Alzheimer's Disease.

Charlottesville, VA (June 26, 2012). Researchers from the Department of Neurosurgery at the David Geffen School of Medicine and the Department of Integrative Biology and Physiology at UCLA have found that a diet enriched with docosahexaenoic acid (DHA), an omega-3 fatty acid, and curcumin, a component of the Indian spice turmeric, can protect the injured spinal cord and minimize the clinical and biochemical effects of spinal cord myelopathy in rats. This finding is fleshed out in the article "Dietary therapy to promote neuroprotection in chronic spinal cord injury.

UCLA researchers discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient of curry spice preserved walking ability in rats with spinal-cord injury. Published June 26 in the Journal of Neurosurgery: Spine, the findings suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.

Athens, Ga. – People love social networks. That's the obvious conclusion from Facebook's 900 million active users and its current standing as one of the most visited sites on the web, second only to Google. New research from the University of Georgia finds what people may really "like" about social networking are themselves.

"Despite the name 'social networks,' much user activity on networking sites is self-focused," said Brittany Gentile, a UGA doctoral candidate who looked at the effects of social networks on self-esteem and narcissism.

In the brains of humans and non-human primates, over 100 billion nerve cells build up complicated neural circuits and produce higher brain functions. When an attempt is made to perform gene therapy for neurological diseases like Parkinson's disease, it is necessary to specify a responsible neural circuit out of many complicated circuits. Until now, however, it was difficult to introduce a target gene into this particular circuit selectively.

The number of children diagnosed with autism spectrum disorder (ASD) has recently increased to one in 100. New research published in BioMed Central's open access journal BMC Medicine demonstrates that EEG can distinguish between children with autism and neurotypical controls. Autistic children showed a reduction in short range connectivity indicating poor function of local brain networks, especially in the left hemisphere regions responsible for language.

Boston, MA, June 25, 2012—Widely available EEG testing can distinguish children with autism from neurotypical children as early as age 2, finds a study from Boston Children's Hospital. The study is the largest, most rigorous study to date to investigate EEGs as a potential diagnostic tool for autism, and offers hope for an earlier, more definitive test.