Neurons communicate by passing electrical messages, known as action potentials, between each other. Each neuron has a highly specialized structural region, the axon initial segment (AIS), whose primary role is in the generation and sending of these messages. The AIS can undergo changes in size and location in response to alterations of a neuron's ongoing electrical activity. However, until now, all such 'AIS plasticity' has been exceptionally slow, occurring over a timescale of days.