Brain scans have revealed how a genetic mutation linked to major psychiatric disorders affects the structure, function and chemistry of the brain.
The study offers further clues about how the mutation increases the risk of schizophrenia, bipolar disorder and depression.
Experts say the findings could help in the quest for new treatments.
Researchers led by the University of Edinburgh scanned the brains of people that have a specific genetic mutation that causes part of one chromosome to swap places with another.