Brain

Massachusetts General Hospital (MGH) researchers are investigating a new approach to gene therapy for brain tumors – delivering a cancer-fighting gene to normal brain tissue around the tumor to keep it from spreading. An animal study published in the journal Molecular Therapy, the first to test the feasibility of such an approach, found that inducing mouse brain cells to secrete human interferon-beta suppressed and eliminated growth of human glioblastoma cells implanted nearby.

Zurich, Switzerland – September 24, 2008 – Love a rap artist's music, and you may develop fond feelings for the products placed in that artist's rap video. That is essentially the conclusion that a team of investigators came to in an intriguing research article published in this month's issue of Psychology & Marketing (P&M).

Eight-year-old children have a radically different learning strategy from twelve-year-olds and adults. Eight-year-olds learn primarily from positive feedback ('Well done!'), whereas negative feedback ('Got it wrong this time') scarcely causes any alarm bells to ring. Twelve-year-olds are better able to process negative feedback, and use it to learn from their mistakes. Adults do the same, but more efficiently.

Brain areas for cognitive control

RICHLAND, Wash. -- A single fluorescent molecule flashing as it gains or loses its electron has made the microscopic spotlight. Watching a whole gaggle of these molecules, they appear to work synchronously; but a new close-up view reveals mavericks that shine when they seemingly shouldn't. The work sets the stage for a better understanding of the underlying principles of certain reactions common to biofuel production.

Research led by Dr. David Spence of Robarts Research Institute at The University of Western Ontario shows that with more intensive medical therapy, the risk of stroke has become so low that at least 95 per cent of patients with asymptomatic carotid stenosis (ACS) would be better off with medical therapy than with surgery or stenting. ACS is a narrowing in the carotid artery, which supplies blood to the brain, which has not yet resulted in a stroke or transient ischemic attack (TIA).

HILTON HEAD, SC–The coordination of two systems are key for any horse to walk, trot, gallop or win a race. The first are the lower limbs, which allow the animal to move along on a "spring-like" tendon. The second is a complicated respiratory system, which allows a horse to take in one breadth for every stride they make while racing. For more than a decade a team of researchers has been working to unlock the secrets of equines. Their findings may provide a springboard for better muscular horse health, and a different approach to breathing devices for humans.

American children are approximately three times more likely to be prescribed psychotropic medication than children in Europe. A new study published today in BioMed Central's open access journal Child and Adolescent Psychiatry and Mental Health claims that the differences may be accounted for by regulatory practices and cultural beliefs about the role of medication in emotional and behavioural problems.

Researchers have long known that children who grow up in an aggressive or violent household are more likely to become violent or aggressive in future relationships. What has not been so clear is the developmental link between witnessing aggressive behavior as a child and carrying it out as an adult. What changes occur in a child that affect whether he or she will choose to deal with conflict in aggressive or violent ways?

Although school has been back for less than a month, it is likely that many children are already experiencing frustration and confusion in math class. Research at The University of Western Ontario in London, Canada could change the way we view math difficulties and how we assist children who face those problems.

Neuroscientists at Children's Hospital Boston have identified the first known "master switch" in brain cells to orchestrate the formation and maintenance of inhibitory synapses, essential for proper brain function. The factor, called Npas4, regulates more than 200 genes that act in various ways to calm down over-excited cells, restoring a balance that is thought to go askew in some neurologic disorders. The findings appear in the September 24 advance online edition of the journal Nature.

A physician's personality can affect practice behavior in inquiries about patient mood symptoms and the diagnosis of depression, according to a study led by University of Rochester Medical Center researchers.

HOUSTON – (Sept. 24, 2008) – Self-guided treatment for depression could soon be only a mouse click away.

Scientists with the National Space Biomedical Research Institute (NSBRI) are developing an interactive, multi-media program that will assist astronauts in recognizing and effectively managing depression and other psychosocial problems, which can pose a substantial threat to crew safety and mission operations during long-duration spaceflights.

Scientists now have a better understanding of how the human brain orchestrates the sophisticated pathways involved in the regulation of emotions. The research, published by Cell Press in the September 25th issue of the journal Neuron, identifies brain pathways that underlie reinterpretation of aversive images in ways that reduce or enhance their negative emotional intensity.

A new study describes an exciting approach for mapping the specific neuronal origins of complex and varied behaviors characteristic of Rett syndrome (RTT), an autism spectrum disorder. The research, published by Cell Press in the September 25th issue of the journal Neuron, also uncovers a novel and unexpected role for the gene that causes RTT.

A link between certain behaviors and the lack of the protein associated with Rett Syndrome – a devastating autism spectrum disorder – demonstrates the importance of MeCP2 (the protein) and reveals never-before recognized functions associated with aggression and obesity, said researchers at Baylor College of Medicine in a report in the current issue of the journal Neuron.