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Hepatitis B virus mutations may predict risk of liver cancer

Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a large meta-analysis in the Journal of the National Cancer Institute, published online July 2.

Improving the biomarker pipeline for early cancer detection

Several statistical and biological issues need to be addressed in order to improve biomarker identification for early detection of cancer, according to a commentary published online July 2 in the Journal of the National Cancer Institute.

The biomarker pipeline to develop and evaluate cancer screening tests includes the identification of promising biomarkers to detect cancers early and the initial and definitive evaluation of biomarkers for cancer screening.

Perfect pitch in musicians may be genetic

Practice, practice, practice might get you to Carnegie Hall, but for aspiring musicians, there's new evidence that genes may influence one's ability to get there, as well.

Perfect pitch, also known as absolute pitch, is the rare ability to recognize and name musical notes without any reference pitch for comparison, detecting, for instance, A before middle C. The rarity of the aptitude contrasts with the common ability to immediately recognize and name colors, distinguishing pink from red or azure from blue.

Plants' internal clock can improve climate-change models

The ability of plants to tell the time, a mechanism common to all living beings, enables them to survive, grow and reproduce. In a study published in the latest issue of the prestigious journal Ecology Letters, an international team has studied this circadian clock from a molecular viewpoint and has found an ecological implication: it makes climate change scenarios and CO2 level figures more accurate.

Why H1N1 influenza A swine flu spreads inefficiently

CAMBRIDGE, Mass.—A team from MIT and the Centers for Disease Control and Prevention has found a genetic explanation for why the new H1N1 "swine flu" virus has spread from person to person less effectively than other flu viruses.

The H1N1 strain, which circled the globe this spring, has a form of surface protein that binds inefficiently to receptors found in the human respiratory tract, the team reports in the July 2 online edition of Science.

Prostate cancer patients disease free after 5 years likely to be disease free after 10 years

Prostate cancer patients who receive brachytherapy and remain free of disease for five years or greater are unlikely to have a recurrence at 10 years, according to a study in the July 1 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Radiation Oncology (ASTRO).

Brachytherapy is the placement of radioactive sources in or just next to a tumor either permanently or temporarily, depending upon the cancer.

Prostate cancer patients disease free after five years likely to be disease free after 10 years

Prostate cancer patients who receive brachytherapy and remain free of disease for five years or greater are unlikely to have a recurrence at 10 years, according to a study in the July 1 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Radiation Oncology (ASTRO).

Brachytherapy is the placement of radioactive sources in or just next to a tumor either permanently or temporarily, depending upon the cancer.

New targeted therapy finds and eliminates deadly leukemia stem cells

New research describes a molecular tool that shows great promise as a therapeutic for human acute myeloid leukemia (AML), a notoriously treatment-resistant blood cancer. The study, published by Cell Press in the July 2nd issue of the journal Cell Stem Cell, describes exciting preclinical studies in which a new therapeutic approach selectively attacks human cancer cells grown in the lab and in animal models of leukemia.

Research reveals what drives lung cancer's spread

NEW YORK, JULY 2, 2009 – A new study by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) reveals the genetic underpinnings of what causes lung cancer to quickly metastasize, or spread, to the brain and the bone – the two most prominent sites of lung cancer relapse. The study will be published online in the journal Cell on July 2.

Found: molecular differences between embryonic stem cells and reprogrammed skin cells

UCLA researchers have found that embryonic stem cells and skin cells reprogrammed into embryonic-like cells have inherent molecular differences, demonstrating for the first time that the two cell types are clearly distinguishable from one another.

Bioethicists lead call for public debates on future uses of stem cells

More than 40 scientists, bioethicists, lawyers and science journal editors are calling on their colleagues, policy makers and the public to begin developing guidelines for the research and reproductive use of stem cell-derived eggs and sperm, even though such use may be a decade or more away.

Ben-Gurion U. researchers reveal connection between cancer and human evolution

BEER-SHEVA, ISRAEL, July 2, 2009 – Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer.

The findings were recently the cover story in the journal Genome Research.

Nanoparticle-delivered compound stops retinopathy, says study

OKLAHOMA CITY – Researchers at the University of Oklahoma Health Sciences Center have found a way to use a natural compound to stop one of the leading causes of blindness in the United States. The research appears online this month in the journal Diabetes, a publication of the American Diabetes Association.

In the eye of the storm: Why some people stayed behind

Hurricane Katrina was the largest natural disaster in U.S. history, claiming the lives of more than 1,800 victims and causing well over $100 billion in damage along the Gulf Coast. The 2005 storm breached every levee in New Orleans, flooding almost the entire city as well as the neighboring parishes. Yet a surprising number of people stayed behind and rode out the storm.

The problem with self-help books: Study shows the negative side to positive self-statements

In times of doubt and uncertainty, many Americans turn to self-help books in search of encouragement, guidance and self-affirmation. The positive self-statements suggested in these books, such as "I am a lovable person" or "I will succeed," are designed to lift a person's low self-esteem and push them into positive action. According to a recent study in Psychological Science, a journal of the Association for Psychological Science, however, these statements can actually have the opposite effect.