Body

LA JOLLA, CA – September 17, 2009 –– A recent study by Scripps Research Institute scientists offers good news for families of children afflicted with the rare genetic disorder, cystinosis. In research that holds out hope for one day developing a potential therapy to treat the fatal disorder, the study shows that the genetic defect in mice can be corrected with stem cell transplantation.

In the late 1920s, people intentionally introduced birds known as Japanese white-eyes into Hawaiian agricultural lands and gardens for purposes of bug control. Now, that decision has come back to bite us. A recent increase in the numbers of white-eyes that live in old-growth forests is leaving native bird species with too little to eat, according to a report published online on September 17th in Current Biology, a Cell Press publication.

Many of the genes that regulate insulin also alter the timing of the circadian clock, a new study has found.

Although insulin responses were known to follow daily rhythms, the finding that components of the insulin-control system can reset the body's clock surprised the study's authors and suggests new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle.

PHILADELPHIA – While scientists have known for several years that our body's internal clock helps regulate many biological processes, researchers have found that the reverse is also true: Many common biological processes – including insulin metabolism – regulate the clock, according to a new study by investigators at the University of Pennsylvania School of Medicine, the Genomics Institute of the Novartis Research Foundation, and the University of California at San Diego.

In finally answering an elusive scientific question, researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the selective placement of strain can alter the electronic phase and its spatial arrangement in correlated electron materials. This unique class of materials is commanding much attention now because they can display properties such as colossal magnetoresistance and high-temperature superconductivity, which are highly coveted by the high-tech industry.

September 16, 2009 - Oakland, CA – An important analysis conducted by Children's Hospital Oakland Research Institute scientists suggests the importance of ensuring optimal dietary intakes of vitamin K to prevent age-related conditions such as bone fragility, arterial and kidney calcification, cardiovascular disease, and possibly cancer (1). Vitamin K is concentrated in dark green plants such as spinach or Swiss chard, and is either not present or present in only small amounts in most multivitamin pills.

Spanish scientists have developed a model to identify the agricultural areas with the greatest potential for restoring the habitat of the Iberian lynx (Lynx pardinus), which is at risk of extinction. The study shows that olive groves with low production close to the Natural Park of the Sierra de Cardeña y Montoro, in Córdoba – which is the only place, along with Doñana, where this species lives – are the most appropriate sites for this purpose.

The U.S. Department of Energy's (DOE's) Thomas Jefferson National Accelerator Facility marked a step forward in the field of advanced particle accelerator technology with the successful test of the first U.S.-built superconducting radiofrequency (SRF) niobium cavity to meet the exacting specifications of the proposed International Linear Collider (ILC).

NEW YORK (September 16, 2009) -- Attempts to eradicate tuberculosis (TB) are stymied by the fact that the disease-causing bacteria have a sophisticated mechanism for surviving dormant in infected cells. Now, a team of scientists led by researchers from Weill Cornell Medical College has identified compounds that inhibit that mechanism -- without damaging human cells.

New Rochelle, NY, September 17, 2009—Risk factors for metabolic syndrome, such as obesity, high blood pressure, and elevated blood lipid levels, can increase a person's healthcare costs nearly 1.6-fold, or about $2,000 per year. For each additional risk factor those costs rise an average of 24%, according to an illuminating article in a recent issue of Metabolic Syndrome and Related Disorders, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online at www.liebertpub.com/met

A protein found present in all cells in the body could help scientists better understand how we store fat.

Researchers at the University of Edinburgh have found that the protein invadolysin, which is essential for healthy cell division, is present in lipid droplets – the parts of cells used to store fat.

The study also found that lower levels of invadolysin were linked to reduced amounts of fat deposits.

Like vampires, cancer tumors require an ample supply of blood to stay alive. Without fresh blood for sustenance, cancer cells shrivel up like raisins and die.

Jerusalem, Sept. 16, 2009 – Discovery by Hebrew University of Jerusalem researchers of an additional role for a key molecule in our bodies provides a further step in world-wide efforts to develop genetic regulation aimed at controlling many diseases, including AIDS and various types of cancers.

Researchers at the Department of Biochemistry and Molecular Biology of Universitat Autònoma de Barcelona (UAB) have revealed the process by which proteins with a tendency to cause conformational diseases such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc. finally end up causing them. Researchers have carried out an analysis of their 3D structure and studied why these proteins finally become toxic although they are correctly folded, an indicator that they are functioning correctly.

UCSF researchers have identified collections of tiny molecules known as microRNAs that affect distinct processes critical for the progression of cancer. The findings, they say, expand researchers' understanding of the important regulatory function of microRNAs in tumor biology and point to new directions for future study and potential treatments.